Patents by Inventor Vincent D. Antle

Vincent D. Antle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALKYLATED CYCLODEXTRIN COMPOSITIONS AND PROCESSES FOR PREPARING AND USING THE SAME
    Publication number: 20230357451
    Abstract: The present disclosure is related to processes for efficient large-scale preparation of alkylated cyclodextrins. The processes of the present disclosure provide high purity alkylated cyclodextrins with high purity and low levels of chloride while improving efficiency, increasing batch size, and reducing total process time.
    Type: Application
    Filed: September 23, 2021
    Publication date: November 9, 2023
    Inventors: Vincent D. ANTLE, Andre FERNANDES, Mariana RODRIGUES, Claudio VILELA
  • Sulfoalkyl ether cyclodextrin compositions
    Patent number: 11806402
    Abstract: SAE-CD compositions are provided, along with methods of making and using the same. The SAE-CD compositions comprise a sulfoalkyl ether cyclodextrin having an absorption of less than 0.5 A.U. due to a drug-degrading agent, as determined by UV/vis spectrophotometry at a wavelength of 245 nm to 270 nm for an aqueous solution containing 300 mg of the SAE-CD composition per mL of solution in a cell having a 1 cm path length.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: November 7, 2023
    Assignee: CyDex Pharmaceuticals, Inc.
    Inventor: Vincent D. Antle
  • Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same
    Patent number: 11795241
    Abstract: The present invention relates to compositions comprising fractionated alkylated cyclodextrin compositions having a single degree of substitution, and processes for preparing and using the same.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: October 24, 2023
    Assignee: CyDex Pharmaceuticals, Inc.
    Inventors: Vincent D. Antle, Charles Alan Watson, David W. Miles
  • ALKYLATED CYCLODEXTRIN COMPOSITIONS AND PROCESSES FOR PREPARING AND USING THE SAME
    Publication number: 20230002513
    Abstract: The present disclosure is related to low-chloride alkylated cyclodextrin compositions, along with processes for preparing the same. The processes of the present invention provide alkylated cyclodextrins with low levels of chloride.
    Type: Application
    Filed: November 16, 2020
    Publication date: January 5, 2023
    Inventor: Vincent D. Antle
  • MANUFACTURING PROCESS FOR CYCLODEXTRIN DERIVATIVES
    Publication number: 20220332853
    Abstract: A process and equipment assembly for reacting a substituent precursor with a cyclodextrin starting material to provide a raw product comprising a cyclodextrin derivative and 1% or less of an initial amount of the substituent precursor is provided. The process of the present invention provides cyclodextrin derivatives in substantially shorter time and with fewer side products than previous processes that utilize substantially the same starting materials.
    Type: Application
    Filed: December 17, 2021
    Publication date: October 20, 2022
    Inventors: Vincent D. Antle, Jose R. Matos
  • Manufacturing process for cyclodextrin derivatives
    Patent number: 11208500
    Abstract: A process and equipment assembly for reacting a substituent precursor with a cyclodextrin starting material to provide a raw product comprising a cyclodextrin derivative and 1% or less of an initial amount of the substituent precursor is provided. The process of the present invention provides cyclodextrin derivatives in substantially shorter time and with fewer side products than previous processes that utilize substantially the same starting materials.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: December 28, 2021
    Assignee: CyDex Pharmaceuticals, Inc.
    Inventors: Vincent D. Antle, Jose R. Matos
  • FRACTIONATED ALKYLATED CYCLODEXTRIN COMPOSITIONS AND PROCESSES FOR PREPARING AND USING THE SAME
    Publication number: 20210147582
    Abstract: The present invention relates to compositions comprising fractionated alkylated cyclodextrin compositions having a single degree of substitution, and processes for preparing and using the same.
    Type: Application
    Filed: November 24, 2020
    Publication date: May 20, 2021
    Inventors: Vincent D. Antle, Charles Alan Watson, David W. Miles
  • SULFOALKYL ETHER CYCLODEXTRIN COMPOSITIONS
    Publication number: 20210093727
    Abstract: SAE-CD compositions are provided, along with methods of making and using the same. The SAE-CD compositions comprise a sulfoalkyl ether cyclodextrin having an absorption of less than 0.5 A.U. due to a drug-degrading agent, as determined by UV/vis spectrophotometry at a wavelength of 245 nm to 270 nm for an aqueous solution containing 300 mg of the SAE-CD composition per mL of solution in a cell having a 1 cm path length.
    Type: Application
    Filed: September 15, 2020
    Publication date: April 1, 2021
    Inventor: Vincent D. Antle
  • Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same
    Patent number: 10851184
    Abstract: The present invention relates to compositions comprising fractionated alkylated cyclodextrin compositions having a single degree of substitution, and processes for preparing and using the same.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: December 1, 2020
    Assignee: CyDex Pharmaceuticals, Inc.
    Inventors: Vincent D. Antle, Charles Alan Watson, David W. Miles
  • Alkylated cyclodextrin compositions and processes for preparing and using the same
    Patent number: 10800861
    Abstract: The present invention related to low-chloride alkylated cyclodextrin compositions, along with processes for preparing and using the same. The processes of the present invention provide alkylated cyclodextrins with low levels of drug-degrading agents and chloride.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: October 13, 2020
    Assignee: CyDex Pharmaceuticals, Inc.
    Inventors: Vincent D. Antle, Álvaro Lopes, Daniel Monteiro
  • Sulfoalkyl ether cyclodextrin compositions
    Patent number: 10780177
    Abstract: SAE-CD compositions are provided, along with methods of making and using the same. The SAE-CD compositions comprise a sulfoalkyl ether cyclodextrin having an absorption of less than 0.5 A.U. due to a drug-degrading agent, as determined by UV/vis spectrophotometry at a wavelength of 245 nm to 270 nm for an aqueous solution containing 300 mg of the SAE-CD composition per mL of solution in a cell having a 1 cm path length.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: September 22, 2020
    Assignee: CyDex Pharmaceuticals, Inc.
    Inventor: Vincent D. Antle
  • MANUFACTURING PROCESS FOR CYCLODEXTRIN DERIVATIVES
    Publication number: 20200157252
    Abstract: A process and equipment assembly for reacting a substituent precursor with a cyclodextrin starting material to provide a raw product comprising a cyclodextrin derivative and 1% or less of an initial amount of the substituent precursor is provided. The process of the present invention provides cyclodextrin derivatives in substantially shorter time and with fewer side products than previous processes that utilize substantially the same starting materials.
    Type: Application
    Filed: January 24, 2020
    Publication date: May 21, 2020
    Inventors: Vincent D. Antle, Jose R. Matos
  • Manufacturing process for cyclodextrin derivatives
    Patent number: 10633462
    Abstract: A process and equipment assembly for reacting a substituent precursor with a cyclodextrin starting material to provide a raw product comprising a cyclodextrin derivative and 1% or less of an initial amount of the substituent precursor is provided. The process of the present invention provides cyclodextrin derivatives in substantially shorter time and with fewer side products than previous processes that utilize substantially the same starting materials.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: April 28, 2020
    Assignee: CyDex Pharmaceuticals, Inc.
    Inventors: Vincent D. Antle, Jose R. Matos
  • Alkylated cyclodextrin compositions and processes for preparing and using the same
    Patent number: 10323103
    Abstract: The present invention related to low-chloride alkylated cyclodextrin compositions, along with processes for preparing and using the same. The processes of the present invention provide alkylated cyclodextrins with low levels of drug-degrading agents and chloride.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: June 18, 2019
    Assignee: CyDex Pharmaceuticals, Inc.
    Inventors: Vincent D. Antle, Alvaro Lopes, Daniel Monteiro
  • SULFOALKYL ETHER CYCLODEXTRIN COMPOSITIONS
    Publication number: 20190070303
    Abstract: SAE-CD compositions are provided, along with methods of making and using the same. The SAE-CD compositions comprise a sulfoalkyl ether cyclodextrin having an absorption of less than 0.5 A.U. due to a drug-degrading agent, as determined by UV/vis spectrophotometry at a wavelength of 245 nm to 270 nm for an aqueous solution containing 300 mg of the SAE-CD composition per mL of solution in a cell having a 1 cm path length.
    Type: Application
    Filed: November 5, 2018
    Publication date: March 7, 2019
    Inventor: Vincent D. Antle
  • ALKYLATED CYCLODEXTRIN COMPOSITIONS AND PROCESSES FOR PREPARING AND USING THE SAME
    Publication number: 20180346609
    Abstract: The present invention related to low-chloride alkylated cyclodextrin compositions, along with processes for preparing and using the same. The processes of the present invention provide alkylated cyclodextrins with low levels of drug-degrading agents and chloride.
    Type: Application
    Filed: August 2, 2018
    Publication date: December 6, 2018
    Inventors: Vincent D. Antle, Álvaro Lopes, Daniel Monteiro
  • Sulfoalkyl ether cyclodextrin compositions
    Patent number: 10117951
    Abstract: SAE-CD compositions are provided, along with methods of making and using the same. The SAE-CD compositions comprise a sulfoalkyl ether cyclodextrin having an absorption of less than 0.5 A.U. due to a drug-degrading agent, as determined by UV/vis spectrophotometry at a wavelength of 245 nm to 270 nm for an aqueous solution containing 300 mg of the SAE-CD composition per mL of solution in a cell having a 1 cm path length.
    Type: Grant
    Filed: November 30, 2015
    Date of Patent: November 6, 2018
    Assignee: CyDex Pharmaceuticals, Inc.
    Inventor: Vincent D. Antle
  • Alkylated cyclodextrin compositions and processes for preparing and using the same
    Patent number: 10040872
    Abstract: The present invention related to low-chloride alkylated cyclodextrin compositions, along with processes for preparing and using the same. The processes of the present invention provide alkylated cyclodextrins with low levels of drug-degrading agents and chloride.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: August 7, 2018
    Assignee: CyDex Pharmaceuticals, Inc.
    Inventors: Vincent D. Antle, Álvaro Lopes, Daniel Monteiro
  • MANUFACTURING PROCESS FOR CYCLODEXTRIN DERIVATIVES
    Publication number: 20180051098
    Abstract: A process and equipment assembly for reacting a substituent precursor with a cyclodextrin starting material to provide a raw product comprising a cyclodextrin derivative and 1% or less of an initial amount of the substituent precursor is provided. The process of the present invention provides cyclodextrin derivatives in substantially shorter time and with fewer side products than previous processes that utilize substantially the same starting materials.
    Type: Application
    Filed: August 31, 2017
    Publication date: February 22, 2018
    Inventors: Vincent D. Antle, Jose R. Matos
  • FRACTIONATED ALKYLATED CYCLODEXTRIN COMPOSITIONS AND PROCESSES FOR PREPARING AND USING THE SAME
    Publication number: 20170275388
    Abstract: The present invention relates to compositions comprising fractionated alkylated cyclodextrm compositions having a single degree of substitution, and processes for preparing and using the same.
    Type: Application
    Filed: August 21, 2015
    Publication date: September 28, 2017
    Inventors: Vincent D. Antle, Charles Alan Watson, David W. Miles