Patents by Inventor Vincent E. Groppi, Jr.

Vincent E. Groppi, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein affecting K.sub.ATP channels
    Patent number: 5856449
    Abstract: This invention describes the isolation and identification of a new protein, p56, useful for the identification of drugs that will selectively open or close K channels. The protein p56 has a molecular weight of about 56,000 daltons and the N-terminal peptide sequence is: Glu-Pro-Arg-Ala-Pro-Pro-Glu-Lys-Ile-Ala-Ile-Val-Gly-Ala-Gly-Ile.
    Type: Grant
    Filed: November 17, 1994
    Date of Patent: January 5, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventors: Vincent E. Groppi, Jr., Martin R. Deibel, Jr., Mark L. Wolfe, Anthony W. Yem
  • Azidophenylcyanoguanidines as photoaffinity probes
    Patent number: 5525742
    Abstract: This invention comprises novel compounds that are useful and effective as photoaffinity probes useful for the identification of the biochemical components that form K.sub.ATP channels in smooth muscle cells. The probes are described by the formula below, ##STR1## where R.sub.1 is H, C.sub.1-3 alkyl; R.sub.2 is H, C.sub.1-3 alkyl; orR.sub.1 and R.sub.2 may be joined together to form C.sub.3-6 cycloalkyl, or C.sub.3-6 cycloalkyl optionally substituted with C.sub.1-4 alkyl;R.sub.3 is C.sub.1-6 alkyl, or C.sub.6-12 aryl optionally substituted with 1-3 Halogens; or suitable salts thereof.
    Type: Grant
    Filed: June 10, 1994
    Date of Patent: June 11, 1996
    Assignee: The Upjohn Company
    Inventors: Robert C. Gadwood, Vincent E. Groppi, Jr.