Patents by Inventor Vincent Linder
Vincent Linder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190072552Abstract: An assay device and method are described. The assay may involve immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion of a surface of a microfluidic chamber; passing a fluid sample over the surface and allowing the analyte to bind to the binding partner; allowing a metal colloid, e.g., a gold-conjugated antibody, to associate with the bound analyte; flowing a metal solution, e.g., a silver solution, over the surface such as to form an opaque metallic layer; and detecting the presence of said metallic layer, e.g., by visual inspection or by measuring light transmission through the layer, conductivity or resistance of the layer, or metal concentration in the metal solution after flowing the metal solution over the surface.Type: ApplicationFiled: September 20, 2018Publication date: March 7, 2019Applicant: President and Fellows of Harvard CollegeInventors: Samuel K. Sia, Vincent Linder, Babak Parviz, Adam Carlyn Siegel, George M. Whitesides
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Patent number: 10159978Abstract: Microfluidic systems and methods including those that provide control of fluid flow are provided. Such systems and methods can be used, for example, to control pressure-driven flow based on the influence of channel geometry and the viscosity of one or more fluids inside the system.Type: GrantFiled: November 17, 2017Date of Patent: December 25, 2018Assignee: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller
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Patent number: 10082507Abstract: An assay method is described, which comprises the steps of immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion of a surface of a microfluidic chamber; passing a fluid sample over the surface and allowing the analyte to bind to the binding partner; allowing a metal colloid, e.g., a gold-conjugated antibody, to associate with the bound analyte; flowing a metal solution, e.g., a silver solution, over the surface such as to form an opaque metallic layer; and detecting the presence of said metallic layer, e.g., by visual inspection or by measuring light transmission through the layer, conductivity or resistance of the layer, or metal concentration in the metal solution after flowing the metal solution over the surface.Type: GrantFiled: September 30, 2013Date of Patent: September 25, 2018Assignee: President and Fellows of Harvard CollegeInventors: Samuel K. Sia, Vincent Linder, Babak Parviz, Adam Siegel, George M. Whitesides
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Publication number: 20180236448Abstract: Systems and methods for controlling fluids in microfluidic systems are generally described. In some embodiments, control of fluids involves the use of feedback from one or more processes or events taking place in the microfluidic system. For instance, a detector may detect one or more fluids at a measurement zone of a microfluidic system and one or more signals, or a pattern of signals, may be generated corresponding to the fluid(s). In some cases, the signal or pattern of signals may correspond to an intensity, a duration, a position in time relative to a second position in time or relative to another process, and/or an average time period between events. Using this data, a control system may determine whether to modulate subsequent fluid flow in the microfluidic system. In some embodiments, these and other methods can be used to conduct quality control to determine abnormalities in operation of the microfluidic system.Type: ApplicationFiled: April 19, 2018Publication date: August 23, 2018Applicant: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller
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Patent number: 10048252Abstract: A method and apparatus for delivering one or more fluids. Fluids may be delivered from a common vessel to a chemical, biological or biochemical process.Type: GrantFiled: May 1, 2015Date of Patent: August 14, 2018Assignee: President and Fellows of Harvard CollegeInventors: Vincent Linder, Samuel K. Sia, George M. Whitesides
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Patent number: 9981266Abstract: Systems and methods for controlling fluids in microfluidic systems are generally described. In some embodiments, control of fluids involves the use of feedback from one or more processes or events taking place in the microfluidic system. For instance, a detector may detect one or more fluids at a measurement zone of a microfluidic system and one or more signals, or a pattern of signals, may be generated corresponding to the fluid(s). In some cases, the signal or pattern of signals may correspond to an intensity, a duration, a position in time relative to a second position in time or relative to another process, and/or an average time period between events. Using this data, a control system may determine whether to modulate subsequent fluid flow in the microfluidic system. In some embodiments, these and other methods can be used to conduct quality control to determine abnormalities in operation of the microfluidic system.Type: GrantFiled: July 20, 2015Date of Patent: May 29, 2018Assignee: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller
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Publication number: 20180099272Abstract: Fluidic devices and methods including those that provide storage and/or facilitate fluid handling of reagents are provided. Fluidic devices described herein may include channel segments positioned on two sides of an article, optionally connected by an intervening channel passing through the article. The channel segments may be used to store reagents in the device prior to first use by an end user. The stored reagents may include fluid plugs positioned in linear order so that during use, as fluids flow to a reaction site, they are delivered in a predetermined sequence. The specific geometries of the channel segments and the positions of the channel segments within the fluidic devices described herein may allow fluid reagents to be stored for extended periods of time without mixing, even during routine handling of the devices such as during shipping of the devices, and when the devices are subjected to physical shock or vibration.Type: ApplicationFiled: December 13, 2017Publication date: April 12, 2018Applicant: OPKO Diagnostics, LLCInventors: Jason Taylor, Vincent Linder
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Publication number: 20180085753Abstract: Fluidic systems and methods for analyses are provided. In some embodiments, systems and methods for improved measurement of absorbance/transmission through fluidic systems are described. Specifically, in one set of embodiments, optical elements are fabricated on one side of a transparent fluidic device opposite a series of fluidic channels. The optical elements may guide incident light passing through the device such that most of the light is dispersed away from specific areas of the device, such as intervening portions between the fluidic channels. By decreasing the amount of light incident upon these intervening portions, the amount of noise in the detection signal can be decreased when using certain optical detection systems.Type: ApplicationFiled: October 18, 2017Publication date: March 29, 2018Applicant: OPKO Diagnostics, LLCInventors: David Steinmiller, Vincent Linder
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Publication number: 20180078938Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.Type: ApplicationFiled: December 1, 2017Publication date: March 22, 2018Applicant: OPKO Diagnostics, LLCInventors: Enqing Tan, Vincent Linder, Jason Taylor, David Steinmiller
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Publication number: 20180071735Abstract: Microfluidic systems and methods including those that provide control of fluid flow are provided. Such systems and methods can be used, for example, to control pressure-driven flow based on the influence of channel geometry and the viscosity of one or more fluids inside the system.Type: ApplicationFiled: November 17, 2017Publication date: March 15, 2018Applicant: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller
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Patent number: 9878324Abstract: Fluidic devices and methods including those that provide storage and/or facilitate fluid handling of reagents are provided. Fluidic devices described herein may include channel segments positioned on two sides of an article, optionally connected by an intervening channel passing through the article. The channel segments may be used to store reagents in the device prior to first use by an end user. The stored reagents may include fluid plugs positioned in linear order so that during use, as fluids flow to a reaction site, they are delivered in a predetermined sequence. The specific geometries of the channel segments and the positions of the channel segments within the fluidic devices described herein may allow fluid reagents to be stored for extended periods of time without mixing, even during routine handling of the devices such as during shipping of the devices, and when the devices are subjected to physical shock or vibration.Type: GrantFiled: December 22, 2016Date of Patent: January 30, 2018Assignee: OPKO Diagnostics, LLCInventors: Jason Taylor, Vincent Linder
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Patent number: 9861980Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.Type: GrantFiled: December 20, 2016Date of Patent: January 9, 2018Assignee: OPKO Diagnostics, LLCInventors: Enqing Tan, Vincent Linder, Jason Taylor, David Steinmiller
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Publication number: 20170367783Abstract: Articles and methods for preparing a surface for obtaining a patient sample, such as blood, are generally provided. In some embodiments, the methods involve wiping a surface of skin of a patient in preparation for obtaining a sample (e.g., a blood sample) from the patient. In some embodiments, the methods involve wiping the surface of the skin with two or more wipes. For instance, the surface of the skin may be wiped with a first wipe comprising a surfactant and a second wipe comprising an antiseptic solution. Advantageously, the use of a first wipe including a surfactant followed by a second wipe may remove a higher amount of certain contaminants (e.g., proteins, bacteria, viruses) from the surface of the skin as compared to the use of a single wipe or by hand-washing alone.Type: ApplicationFiled: October 13, 2016Publication date: December 28, 2017Applicant: OPKO Diagnostics, LLCInventors: Jason Taylor, David Steinmiller, Hardeep Singh, Rebecca Wagner, Gary J. Fagan, Vincent Linder
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Publication number: 20170370938Abstract: Aspects of the disclosure relate to improved methods for predicting whether a prostate tissue biopsy obtained from a subject will contain detectable prostate cancer. In some embodiments, the disclosure provides improved prostate antigen standards for quantifying levels of prostate antigens.Type: ApplicationFiled: March 25, 2016Publication date: December 28, 2017Applicant: OPKO Diagnostics, LLCInventors: Vincent Linder, Christina Higgins
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Patent number: 9849455Abstract: Microfluidic systems and methods including those that provide control of fluid flow are provided. Such systems and methods can be used, for example, to control pressure-driven flow based on the influence of channel geometry and the viscosity of one or more fluids inside the system.Type: GrantFiled: February 27, 2017Date of Patent: December 26, 2017Assignee: OPKO Diagnostics, LLCInventors: Vincent Linder, David Steinmiller
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Patent number: 9827563Abstract: Fluidic systems and methods for analyses are provided. In some embodiments, systems and methods for improved measurement of absorbance/transmission through fluidic systems are described. Specifically, in one set of embodiments, optical elements are fabricated on one side of a transparent fluidic device opposite a series of fluidic channels. The optical elements may guide incident light passing through the device such that most of the light is dispersed away from specific areas of the device, such as intervening portions between the fluidic channels. By decreasing the amount of light incident upon these intervening portions, the amount of noise in the detection signal can be decreased when using certain optical detection systems.Type: GrantFiled: June 29, 2016Date of Patent: November 28, 2017Assignee: OPKO Diagnostics, LLCInventors: David Steinmiller, Vincent Linder
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Patent number: 9827564Abstract: Fluidic systems and methods for analysis are provided. In some embodiments, systems and methods for improved measurement of absorbance/transmission through fluidic systems are described. Specifically, in one set of embodiments, optical elements are fabricated on one side of a transparent fluidic device opposite a series of fluidic channels. The optical elements may guide incident light passing through the device such that most of the light is dispersed away from specific areas of the device, such as intervening portions between the fluidic channels. By decreasing the amount of light incident upon these intervening portions, the amount of noise in the detection signal can be decreased when using certain optical detection systems.Type: GrantFiled: June 29, 2016Date of Patent: November 28, 2017Assignee: OPKO Diagnostics, LLCInventors: David Steinmiller, Vincent Linder
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Publication number: 20170304822Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions.Type: ApplicationFiled: July 12, 2017Publication date: October 26, 2017Applicant: OPKO Diagnostics, LLCInventors: Enqing Tan, Vincent Linder
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Patent number: D804682Type: GrantFiled: August 10, 2015Date of Patent: December 5, 2017Assignee: OPKO Diagnostics, LLCInventors: Jason Taylor, Matthew Dirckx, David Steinmiller, Vincent Linder
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Patent number: D817511Type: GrantFiled: June 30, 2017Date of Patent: May 8, 2018Assignee: OPKO Diagnostics, LLCInventors: Jason Taylor, Matthew Dirckx, David Steinmiller, Vincent Linder