Patents by Inventor Vincenzo Di Marzo
Vincenzo Di Marzo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140066399Abstract: The present invention relates to topical preparations containing N-palmitoyl-vanillamide having hyperalgesic activity. In particular, the invention relates to N-palmitoyl-vanillamide for use in the treatment of pathologies selected from: post-herpetic neuralgia, neuralgia of trigeminus, occipital neuralgia, dental neuralgia, glottopharyngeal neuralgia, uremic neuralgia, diabetic neuralgia, headache of different origin, neuropathic itch, neurogenic itch, uremic itch, vulvodinia, vulvar vestibulitis, ano-rectal pain and itch, balano-preputial pain and itch, painful urogenital disorders of dogs and cats, psoriasis-associated pruritus and pain, itching skin diseases (e.g. atopic dermatitis) in the human and veterinary field, muscular pain, pain of the tendon, osteoarthritis associated pain in humans, dogs and cats; painful eye diseases in the human and veterinary field, inflammatory pathologies of the oral cavity in the human and veterinary field.Type: ApplicationFiled: August 28, 2013Publication date: March 6, 2014Applicant: EPITECH GROUP S.R.L.Inventors: Francesco Della Valle, Luciano De Petrocellis, Sabatino Maione, Vincenzo Di Marzo, Maria Federica Della Valle
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Patent number: 8546352Abstract: The present invention relates to topical preparations containing N-palmitoyl-vanillamide having hyperalgesic activity. In particular, the invention relates to N-palmitoyl-vanillamide for use in the treatment of pathologies selected from: post-herpetic neuralgia, neuralgia of trigeminus, occipital neuralgia, dental neuralgia, glottopharyngeal neuralgia, uremic neuralgia, diabetic neuralgia, headache of different origin, neuropathic itch, neurogenic itch, uremic itch, vulvodinia, vulvar vestibulitis, ano-rectal pain and itch, balano-preputial pain and itch, painful urogenital disorders of dogs and cats, psoriasis-associated pruritus and pain, itching skin diseases (e.g. atopic dermatitis) in the human and veterinary field, muscular pain, pain of the tendon, osteoarthritis associated pain in humans, dogs and cats; painful eye diseases in the human and veterinary field, inflammatory pathologies of the oral cavity in the human and veterinary field.Type: GrantFiled: November 8, 2011Date of Patent: October 1, 2013Assignee: Epitech Group S.r.l.Inventors: Francesco Della Valle, Luciano De Petrocellis, Sabatino Maione, Vincenzo Di Marzo, Maria Federica Della Valle
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Publication number: 20130059018Abstract: This invention relates to the use of phytocannabinoids, either in an isolated form or in the form of a botanical drug substance (BDS) in the treatment of cancer. Preferably the cancer to be treated is cancer of the prostate, cancer of the breast or cancer of the colon.Type: ApplicationFiled: March 11, 2011Publication date: March 7, 2013Applicants: OTSUKA PHARMACEUTICAL CO., LIMITED, GW PHARMA LIMITEDInventors: Daniela Parolaro, Paola Massi, Angelo Antonio Izzo, Francesca Borelli, Gabriella Aviello, Vincenzo Di Marzo, Luciano De Petrocellis, Aniello Schiano Moriello, Alessia Ligresti, Ruth Alexandra Ross, Lesley Ann Ford, Sharon Anavi-Goffer, Manuel Guzman, Guillermo Velasco, Mar Lorente, Sofia Torres, Tetsuro Kikuchi, Geoffrey Guy, Colin Stott, Stephen Wright, Alan Sutton, David Potter, Etienne De Meijer
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Publication number: 20120115808Abstract: The present invention relates to topical preparations containing N-palmitoyl-vanillamide having hyperalgesic activity. In particular, the invention relates to N-palmitoyl-vanillamide for use in the treatment of pathologies selected from: post-herpetic neuralgia, neuralgia of trigeminus, occipital neuralgia, dental neuralgia, glottopharyngeal neuralgia, uremic neuralgia, diabetic neuralgia, headache of different origin, neuropathic itch, neurogenic itch, uremic itch, vulvodinia, vulvar vestibulitis, ano-rectal pain and itch, balano-preputial pain and itch, painful urogenital disorders of dogs and cats, psoriasis-associated pruritus and pain, itching skin diseases (e.g. atopic dermatitis) in the human and veterinary field, muscular pain, pain of the tendon, osteoarthritis associated pain in humans, dogs and cats; painful eye diseases in the human and veterinary field, inflammatory pathologies of the oral cavity in the human and veterinary field.Type: ApplicationFiled: November 8, 2011Publication date: May 10, 2012Inventors: Francesco DELLA VALLE, Luciano De Petrocellis, Sabatino Maione, Vincenzo Di Marzo, Maria Federica Della Valle
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Publication number: 20110288037Abstract: The present invention relates to a pharmaceutical composition consisting of amides of mono- and di-carboxylic acids and hydroxystilbenes, and may be used for the treatment of pathologies caused, sustained and/or characterised by an abnormal general response of the immune system, in both humans and animals.Type: ApplicationFiled: August 3, 2011Publication date: November 24, 2011Inventors: Francesco Della Valle, Maria Federica Della Valle, Gabriele Marcolongo, Gianpiero Ravagnan, Vincenzo Di Marzo
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Patent number: 7902251Abstract: The present invention provides pharmaceutical compositions useful in a method for treating neuropathic pain, said method comprising administration of a pain-ameliorating effective amount of the compound according to formula I wherein R is an alk(en)yl group, R1 is an alkylen(yl) group, n is 0 or 1 and Ar is a carbocyclic aryl group.Type: GrantFiled: October 13, 2006Date of Patent: March 8, 2011Assignee: Allergan, Inc.Inventors: Vincenzo Di Marzo, Luciano De Petrocellis, Sabatino Malone, Vito De Novellis
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Publication number: 20100249223Abstract: The present invention relates to the use of cannabinoid-containing plant extracts in the prevention or treatment of diseases or conditions that are alleviated by blockade of one or more types of TRP channel. Preferably the subset of TRP channel that is blockaded is the TRPA channel. More preferably the TRPA channel is the TRPA1 channel. Preferably the diseases or conditions to be prevented or treated include: neuropathic pain, inflammation or vasoconstriction. Alternatively the TRP channel that is blockaded is the TRPM channel. More preferably the TRPM channel is the TRPM8 channel. Preferably the diseases or conditions to be prevented or treated are cancer. More preferably the cancers to be treated include: cancer of the prostate, cancer of the breast, cancer of the colon, cancer of the lung or cancer of the skin. Alternatively the TRP channel that is blockaded is the TRPV channel. More preferably the TRPV channel is the TRPV1 channel.Type: ApplicationFiled: April 17, 2008Publication date: September 30, 2010Applicant: GW Pharma LimitedInventors: Vincenzo Di Marzo, Luciano De Petrocellis, Aniello Schiano Moriello
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Publication number: 20090043129Abstract: The present invention relates to high affinity compounds, able to bind CB1 and CB2 endocannabinoid receptors. The compounds of the invention find particular application as agents for pain therapy and/or anti-inflammatory and/or anti-stress and/or anti-oxidising and/or hypotensive and/or immune suppressive therapy and/or anti-spastic activity in multiple sclerosis and/or anti-cancer.Type: ApplicationFiled: January 24, 2006Publication date: February 12, 2009Inventors: Antonella Brizzi, Vittorio Brizzi, Rossella Sirianni, Vincenzo Di Marzo, Maria Grazia, Tiziana Bisogno
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Patent number: 7429673Abstract: The compounds of the general formula (I) in which X is represents two hydrogen atoms, a ?-bond, oxygen or methylene: R2 is a C6-C12 aryl, or arylalkyl residue: R3 is hydrogen, 2-hydroxyethyl or 2-aminoethyl are useful for the treatment of pathologies mediated by vanilloid receptors type I.Type: GrantFiled: July 6, 2005Date of Patent: September 30, 2008Assignee: Indena S.p.A.Inventors: Paolo Morazzoni, Antonella Riva, Gabriele Fontana, Giovanni Appendino, Vincenzo Di Marzo
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Publication number: 20080132573Abstract: The compounds of the general formula (I) in which X is represents two hydrogen atoms, a ?-bond, oxygen or methylene: R2 is a C6-C12 aryl, or arylalkyl residue: R3 is hydrogen, 2-hydroxyethyl or 2-aminoethyl are useful for the treatment of pathologies mediated by vanilloid receptors type I.Type: ApplicationFiled: July 6, 2005Publication date: June 5, 2008Inventors: Paolo Morazzoni, Antonella Riva, Gabriele Fontana, Giovanni Appendino, Vincenzo Di Marzo
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Publication number: 20070270496Abstract: The present invention relates to a pharmaceutical composition consisting of amides of mono- and di-carboxylic acids and hydroxystilbenes, and may be used for the treatment of pathologies caused, sustained and/or characterised by an abnormal general response of the immune system, in both humans and animals.Type: ApplicationFiled: March 14, 2007Publication date: November 22, 2007Applicant: EPITECH GROUP S.R.L.Inventors: Francesco Della Valle, Maria Della Valle, Gabriele Marcolongo, Gianpiero Ravagnan, Vincenzo Di Marzo
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Publication number: 20070259945Abstract: The present invention provides pharmaceutical compositions useful in a method for treating neuropathic pain, said method comprising administration of a pain-ameliorating effective amount of the compound according to formula I wherein X may be Y may be wherein R is H or (CH2)mH, alternatively the bond between X and Y may be a double or triple bond, e.g. X?Y or X?Y; wherein n is an integer of from 1 to 10, m is an integer of from 1 to 4 and the total carbon atoms in the alkenyl amide chain is from about 11 to about 20 as an active ingredient together with one or more pharmaceutically-acceptable additives, excipients or diluents.Type: ApplicationFiled: October 13, 2006Publication date: November 8, 2007Applicant: ALLERGAN, INC.Inventors: Luciano De Petrocellis, Sabatino Malone, Vito De Novellis, Vincenzo Di Marzo
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Patent number: 7244767Abstract: The present invention relates to the use of N-acylvanillinamide derivatives capable of activating the peripheral receptor CB1 of cannabinoids. In particular, the present invention relates to the use of compounds of general formula (I) in which the meanings of R, R1, R3 and Y are as defined in the description, for the preparation of a medicinal product which is capable of activating the peripheral receptor CB1 of cannabinoids.Type: GrantFiled: September 27, 2004Date of Patent: July 17, 2007Assignees: Innovet Italia S.R.L., Consiglio Nazionale Delle RichercheInventors: Tiziana Bisogno, Francesco Della Valle, Luciano De Petrocellis, Vincenzo Di Marzo, Gabriele Marcolongo, Dominique Melck
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Publication number: 20070129423Abstract: The present invention provides pharmaceutical compositions useful in a method for treating neuropathic pain, said method comprising administration of a pain-ameliorating effective amount of the compound according to formula I wherein R is an alk(en)yl group, R1 is an alkylen(yl) group, n is 0 or 1 and Ar is a carbocyclic aryl group; wherein X is Y is O, S, or NR wherein R is H or (CH2)mH and m is an integer of from 1 to 5 or the bond between X and Y may be a double or triple bond, e.g. as in X?Y or X?Y.Type: ApplicationFiled: February 6, 2007Publication date: June 7, 2007Inventors: Vincenzo Di Marzo, Luciano De Petrocellis, Sabatino Malone, Vito De Novellis, David Woodward
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Publication number: 20070105940Abstract: The present invention provides pharmaceutical compositions useful in a method for treating neuropathic pain, said method comprising administration of a pain-ameliorating effective amount of the compound according to formula I wherein n is an integer of from 1 to 10, m is an integer of from 1 to 4 and the total carbon atoms in the alkenyl amide chain is from about 11 to about 20 as an active ingredient together with one or more pharmaceutically-acceptable additives, excipients or diluents.Type: ApplicationFiled: October 13, 2006Publication date: May 10, 2007Applicant: ALLERGAN, INC.Inventors: Vincenzo Di Marzo, Luciano De Petrocellis, Sabatino Malone, Vito De Novellis
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Publication number: 20070088073Abstract: The present invention provides pharmaceutical compositions useful in a method for treating neuropathic pain, said method comprising administration of a pain-ameliorating effective amount of the compound according to formula I wherein R is an alk(en)yl group, R1 is an alkylen(yl) group, n is 0 or 1 and Ar is a carbocyclic aryl group; wherein X is —CH2—, —CH—, or O, S, or NR wherein R is H or (CH2)mH and m is an integer of from 1 to 5 or the bond between X and Y may be a double or triple bond, e.g. as in X?Y or X?Y.Type: ApplicationFiled: October 13, 2006Publication date: April 19, 2007Applicant: ALLERGAN, INC.Inventors: Vincenzo Di Marzo, Luciano De Petrocellis, Sabatino Malone, Vito De Novellis
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Publication number: 20070088072Abstract: The present invention provides pharmaceutical compositions useful in a method for treating neuropathic pain, said method comprising administration of a pain-ameliorating effective amount of the compound according to formula I wherein R is an alk(en)yl group, R1 is an alkylen(yl) group, n is 0 or 1 and Ar is a carbocyclic aryl group.Type: ApplicationFiled: October 13, 2006Publication date: April 19, 2007Applicant: ALLERGAN, INC.Inventors: Vincenzo Di Marzo, Luciano De Petrocellis, Sabatino Malone, Vito De Novellis
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Publication number: 20050065216Abstract: The present invention relates to the use of N-acylvanillinamide derivatives capable of activating the peripheral receptor CB1 of cannabinoids. In particular, the present invention relates to the use of compounds of general formula (I) in which the meanings of R, R1, R3 and Y are as defined in the description, for the preparation of a medicinal product which is capable of activating the peripheral receptor CB1 of cannabinoids.Type: ApplicationFiled: September 27, 2004Publication date: March 24, 2005Applicants: Innovet Italia S.R.L., Consiglio Nazionale Delle RicercheInventors: Tiziana Bisogno, Francesco Della Valle, Luciano De Petrocellis, Vincenzo Di Marzo, Gabriele Marcolongo, Dominique Melck
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Publication number: 20040122089Abstract: Analogs of andandamide and arvanil have been found to act preferential at CB1 and AR1 receptors, and at receptors other than CB1 and AR1. The analogs provide analgesic effects in vivo, and are useful in pain management. In addition, the analogs may be used as anti-proliferative/anti-tumor agents, vasodilators, and in other applications. Several of the anandamide and arvanil analogs are more potent than anandamide and arvanil.Type: ApplicationFiled: February 13, 2003Publication date: June 24, 2004Inventors: Billy R. Martin, Raj K. Razdan, Vincenzo Di Marzo