Patents by Inventor Vinkal ZALAVADIYA

Vinkal ZALAVADIYA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Asymmetric synthesis of Azaspiro compounds
    Patent number: 11401273
    Abstract: The present invention relates to an improved asymmetric synthesis of azaspiro or diazaspiro compound (hereafter referred to as the compound 5, (5A) or (5N)) or their pharmaceutically acceptable salts and derivatives; through the formation of intermediate compounds 4, (4A) or (4N) respectively. The process comprises an unusual substrate specific highly diastereoselective as well as enantio-enriched 1-substituted 2-azaspiro[3.3]heptane or 1-substituted 2-diazaspiro[3.3]heptane compounds with high diastereoselectivity by addition of a cyclobutane carboxylate anion to a Davis-Ellman's imine, followed by reduction and cyclisation resulting in the selective formation of azaspiro or diazaspiro intermediate compound 4, (4A) or (4N); which on subsequently removing the sulfinyl group provides corresponding azaspiro or diazaspiro compound 5, (5A) or (5N) respectively.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: August 2, 2022
    Assignee: PIRAMAL PHARMA LIMITED
    Inventors: Rajender Reddy Leleti, Yogesh Waman, Priya Kallure, Zubeda Begum, Thumban Divya, Kumara Swamy Nalivela, Saurabh Vijay, Paranjay Parikh, Sharadsrikar Kotturi, Chirag Patel, Krishna Nayak, Kasimraza Baharooni, Vinkal Zalavadiya
  • Process for diastereoselective synthesis of vicinal diamines
    Patent number: 11299455
    Abstract: The present invention relates to an improved process for diastereoselective synthesis of vicinal diamines (1). The process involves highly regio- and diastereoselective addition of 2-azaallyl anions (4) to N-tert-butanesulfinylimines (5) to produce vicinal diamines (1).
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: April 12, 2022
    Assignee: PIRAMAL PHARMA LIMITED
    Inventors: Rajender Reddy Leleti, Sharadsrikar Kotturi, Kumara Swamy Nalivela, Chirag Patel, Poojabahen Raval, Vinkal Zalavadiya
  • AN IMPROVED PROCESS FOR DIASTEREOSELECTIVE SYNTHESIS OF VICINAL DIAMINES
    Publication number: 20220073454
    Abstract: The present invention relates to an improved process for diastereoselective synthesis of vicinal diamines (1). The process involves highly regio- and diastereoselective addition of 2-azaallyl anions (4) to N-tert-butanesulfinylimines (5) to produce vicinal diamines (1).
    Type: Application
    Filed: July 11, 2019
    Publication date: March 10, 2022
    Applicant: PIRAMAL PHARMA LIMITED
    Inventors: Rajender Reddy LELETI, Sharadsrikar KOTTURI, Kumara Swamy NALIVELA, Chirag PATEL, Poojabahen RAVAL, Vinkal ZALAVADIYA
  • AN IMPROVED ASYMMETRIC SYNTHESIS OF AZASPIRO COMPOUNDS
    Publication number: 20220041609
    Abstract: The present invention relates to an improved asymmetric synthesis of azaspiro or diazaspiro compound (hereafter referred to as the compound 5, (5A) or (5N)) or their pharmaceutically acceptable salts and derivatives; through the formation of intermediate compounds 4, (4A) or (4N) respectively. The process comprises an unusual substrate specific highly diastereoselective as well as enantio-enriched 1-substituted 2-azaspiro[3.3]heptane or 1-substituted 2-diazaspiro[3.3]heptane compounds with high diastereoselectivity by addition of a cyclobutane carboxylate anion to a Davis-Ellman's imine, followed by reduction and cyclisation resulting in the selective formation of azaspiro or diazaspiro intermediate compound 4, (4A) or (4N); which on subsequently removing the sulfinyl group provides corresponding azaspiro or diazaspiro compound 5, (5A) or (5N) respectively.
    Type: Application
    Filed: November 19, 2019
    Publication date: February 10, 2022
    Applicant: PIRAMAL PHARMA LIMITED
    Inventors: Rajender Reddy LELETI, Yogesh WAMAN, Priya KALLURE, Zubeda BEGUM, Thumban DIVYA, Kumara Swamy NALIVELA, Saurabh VIJAY, Paranjay PARIKH, Sharadsrikar KOTTURI, Chirag PATEL, Krishna NAYAK, Kasimraza BAHAROONI, Vinkal ZALAVADIYA