Abstract: An applicator is provided for dispensing a first and a second component of a biological adhesive. The applicator includes a housing having a housing head for enclosing therein a first reservoir containing the first component, and a second reservoir containing the second component. The housing further includes an elongated body portion defining a longitudinal axis for enclosing therein a conduit assembly having a first and a second conduit in communication with the first and second reservoir, respectively. An activator assembly is provided which includes an activator and a rachet mechanism for compressing the reservoirs within the housing for dispensing the biological components into the conduits. An applicator tip having two separate channels in communication with the conduits may be provided on a distal end of the elongated body portion for dispensing the components on the application site. The first and second components are preferably fibrinogen and thrombin which intermix to form a fibrin sealant.

Abstract: An applicator is provided for dispensing a first and a second component of a biological adhesive. The applicator includes a housing having a housing head for enclosing therein a first reservoir containing the first component, and a second reservoir containing the second component. The housing further includes an elongated body portion defining a longitudinal axis for enclosing therein a conduit assembly having a first and a second conduit in communication with the first and second reservoir, respectively. An activator assembly is provided which includes an activator and a rachet mechanism for compressing the reservoirs within the housing for dispensing the biological components into the conduits. An applicator tip having two separate channels in communication with the conduits may be provided on a distal end of the elongated body portion for dispensing the components on the application site. The first and second components are preferably fibrinogen and thrombin which intermix to form a fibrin sealant.

Abstract: An apparatus for application of surgical clips to body tissue is disclosed having a handle assembly and an elongated body portion extending distally from the handle assembly. A jaw assembly is mounted at a distal end portion of the elongated body portion and includes first and second jaws movable between an open position and a closed position. An actuator is disclosed which is slidable within the elongated body portion in response to actuation of the handle assembly. The actuator has camming structure at a distal portion thereof for moving the first and second jaws between the open position and the closed position. A loading unit is releasably mounted to the elongated body portion and stores a plurality of surgical clips therein. The loading unit includes a clip advancer having a portion engageable with the actuator and movable therewith for advancing a distalmost surgical clip and a ratchet assembly associated with the clip advancer to index progressive movement thereof.