Patents by Inventor Viola Kooij

Viola Kooij has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of diagnosing and treating heart failure
    Patent number: 10393754
    Abstract: This invention relates to novel phosphorylation sites in cardiac Troponin I that are associated with the onset of heart failure. The phosphorylation sites, i.e., serine 5, tyrosine 26, threonine 51, serine 166, threonine 181 and/or serine 199, can be used as biomarkers for (i) identifying subjects at risk for the development of heart failure, (ii) treating subjects having a higher than normal level of the biomarker, and (iii) monitoring therapy of a subject at risk for the development of heart failure. Also described are antibodies, reagents, and kits for carrying out a method of the present invention.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: August 27, 2019
    Assignees: CEDARS-SINAI MEDICAL CENTER, VU-VUMC IP MANAGEMENT BV
    Inventors: Pingbo Zhang, Jennifer E. Van Eyk, Anne M. Murphy, Ger Stienen, Jolanda van der Velden, Viola Kooij
  • Novel Phosphorylation of Cardiac Troponin I as a Monitor for Cardiac Injury
    Publication number: 20130101606
    Abstract: This invention relates to novel phosphorylation sites in cardiac Troponin I that are associated with the onset of heart failure. The phosphorylation sites, i.e., serine 5, tyrosine 26, threonine 51, serine 166, threonine 181 and/or serine 199, can be used as biomarkers for (i) identifying subjects at risk for the development of heart failure, (ii) treating subjects having a higher than normal level of the biomarker, and (iii) monitoring therapy of a subject at risk for the development of heart failure. Also described are antibodies, reagents, and kits for carrying out a method of the present invention.
    Type: Application
    Filed: February 17, 2011
    Publication date: April 25, 2013
    Applicants: VU-VUMC IP MANAGEMENT BV, THE JOHNS HOPKINS UNIVERSITY
    Inventors: Pingbo Zhang, Jennifer E. Van Eyk, Anne M. Murphy, Ger Stienen, Jolanda van der Velden, Viola Kooij