Patents by Inventor Virgil L. Styles
Virgil L. Styles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5393883Abstract: The present invention relates to novel ribonucleotide reductase inhibitors and new combinations comprising an antiviral compound, such as acyclovir, and a thiocarbonohydrazone ribonucleotide reductase inhibitor for the chemotherapeutic treatment of virus infections, especially viruses of the herpes group.Type: GrantFiled: February 7, 1992Date of Patent: February 28, 1995Assignee: Burroughs Wellcome Co.Inventors: Todd A. Blumenhopf, Thomas Spector, Devron R. Averett, Robert W. Morrison, Jr., Eric C. Bigham, Virgil L. Styles
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Patent number: 5175165Abstract: The present invention relates to novel ribonucleotide reductase inhibitors and new combinations comprising an antiviral compound, such as acyclovir, and a thiocarbonohydrazone ribonucleotide reductase inhibitor for the chemotherapeutic treatment of virus infections, espectially viruses of the herpes group.Type: GrantFiled: June 26, 1989Date of Patent: December 29, 1992Assignee: Burroughs Wellcome Co.Inventors: Todd A. Blumenkopf, Thomas Spector, Devron R. Averett, Robert W. Morrison, Jr., Eric C. Bigham, Virgil L. Styles
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Patent number: 4329362Abstract: The present invention provides pyrimido (4,5-c) pyridazines, to methods for preparing them, formulations containing them and the preparation of such formulation and the use of such compounds in human therapy. These pyrimido (4,5-c)pyridazines of this invention are useful due to their activity as inhibitors of dihydropteroic and biosynthesis.Type: GrantFiled: May 13, 1980Date of Patent: May 11, 1982Assignee: Burroughs Wellcome Co.Inventors: Robert W. Morrison, Jr., William R. Mallory, Virgil L. Styles
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Patent number: 4323679Abstract: The present invention provides pyrimido(4,5-c)pyridazines, to methods for preparing them, formulations containing them and the preparation of such formulation and the use of such compounds in human therapy. These pyrimido(4,5-c)pyridazines of this invention are useful due to their activity as inhibitors of dihydropteroic and biosynthesis.Type: GrantFiled: May 27, 1980Date of Patent: April 6, 1982Assignee: Burroughs Wellcome Co.Inventors: Robert W. Morrison, Jr., William R. Mallory, Virgil L. Styles
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Patent number: 4315932Abstract: Compounds of the general formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are selected from a lower alkyl group, a phenyl group (optionally substituted by one or more hydroxy or lower alkoxy groups), a pyridyl group or a group --CO.sub.2 R where R is a lower alkyl group, (provided that when R.sup.1 is a group --CO.sub.2 R, R.sup.2 is a lower alkyl group) are disclosed.The compounds of formula (I) are useful as intermediates to compounds of other ring systems which are of pharmacological interest.Certain of the compounds of formula (I) are also useful as antimicrobial agents.Type: GrantFiled: September 17, 1979Date of Patent: February 16, 1982Assignee: Burroughs Wellcome Co.Inventors: Robert W. Morrison, Jr., William R. Mallory, Virgil L. Styles
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Patent number: 4303789Abstract: The present invention provides pyrimido (4,5-c) pyridazines, to methods for preparing them, formulations containing them and the preparation of such formulation and the use of such compounds in human therapy. These pyrimido (4,5-c)pyridazines of this invention are useful due to their activity as inhibitors of dihydropteroic and biosynthesis.Type: GrantFiled: May 27, 1980Date of Patent: December 1, 1981Assignee: Burroughs Wellcome Co.Inventors: Robert W. Morrison, Jr., William R. Mallory, Virgil L. Styles
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Patent number: 4303790Abstract: The present invention provides pyrimido(4,5-c)pyridazines, to methods for preparing them, formulations containing them and the preparation of such formulation and the use of such compounds in human therapy. These pyrimido(4,5-c)pyridazines of this invention are useful due to their activity as inhibitors of dihydropteroic and biosynthesis.Type: GrantFiled: May 27, 1980Date of Patent: December 1, 1981Assignee: Burroughs Wellcome Co.Inventors: Robert W. Morrison, Jr., William R. Mallory, Virgil L. Styles
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Patent number: 4302587Abstract: The present invention provides pyrimido (4,5-c) pyridazines, to methods for preparing them, formulations containing them and the preparation of such formulation and the use of such compounds in human therapy. These pyrimido (4,5-c)pyridazines of this invention are useful due to their activity as inhibitors of dihydropteroic and biosynthesis.Type: GrantFiled: May 27, 1980Date of Patent: November 24, 1981Assignee: Burroughs Wellcome Co.Inventors: Robert W. Morrison, Jr., William R. Mallory, Virgil L. Styles
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Patent number: 4288365Abstract: Compounds of the general formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are selected from a lower alkyl group, a phenyl group (optionally substituted by one or more hydroxy or lower alkoxy groups), a pyridyl group or a group --CO.sub.2 R where R is a lower alkyl group, (provided that when R.sup.1 is a group --CO.sub.2 R, R.sup.2 is a lower alkyl group) are disclosed.The compounds of formula (I) are useful as intermediates to compounds of other ring systems which are of pharmacological interest.Certain of the compounds of formula (I) are also useful as antimicrobial agents.Type: GrantFiled: September 17, 1979Date of Patent: September 8, 1981Assignee: Burroughs Wellcome Co.Inventors: Robert W. Morrison, Jr., William R. Mallory, Virgil L. Styles
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Patent number: 4260758Abstract: Novel compounds of the general formula (XIX) ##STR1## where R.sup.9 is selected from lower alkyl, phenyl, phenyl substituted by one or more hydroxy or lower alkoxy, or pyridyl, are disclosed.A method of making the compounds of Formula (XIX) is disclosed, which comprises heating in aqueous acid a compound of formula (XX) ##STR2## wherein R.sup.10 is selected from lower alkyl, phenyl, phenyl substituted by one or more hyroxy or lower alkoxy or pyridyl and R.sup.11 is selected from lower alkyl, phenyl, substituted by one or more hydroxy or lower alkoxy, pyridyl or --CO.sub.2 R where R is lower alkyl.Type: GrantFiled: September 17, 1979Date of Patent: April 7, 1981Assignee: Burroughs Wellcome Co.Inventors: Robert W. Morrison, Jr., William R. Mallory, Virgil L. Styles
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Patent number: 4255427Abstract: This invention provides pyrimido (4,5-c)pyridazines, process for their preparation, veterinary compositions containing them and the preparation of such compositions. These pyrimido (4,5-c)pyridazines are useful in the treatment of coccidiosis.Type: GrantFiled: July 7, 1978Date of Patent: March 10, 1981Assignee: Burroughs Wellcome Co.Inventors: Robert W. Morrison, Jr., William R. Mallory, Virgil L. Styles
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Patent number: 4237289Abstract: Compounds of the general formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are selected from a lower alkyl group, a phenyl group (optionally substituted by one or more hydroxy or lower alkoxy groups), a pyridyl group or a group --CO.sub.2 R where R is a lower alkyl group, (provided that when R.sup.1 is a group --CO.sub.2 R, R.sup.2 is a lower alkyl group) are disclosed.The compounds of formula (I) are useful as intermediates to compounds of other ring systems which are of pharmacological interest.Certain of the compounds of formula (I) are also useful as antimicrobial agents.Type: GrantFiled: September 17, 1979Date of Patent: December 2, 1980Assignee: Burroughs Wellcome Co.Inventors: Robert W. Morrison, Jr., William R. Mallory, Virgil L. Styles
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Patent number: 4235905Abstract: Compounds of the general formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are selected from a lower alkyl group, a phenyl group (optionally substituted by one or more hydroxy or lower alkoxy groups), a pyridyl group or a group --CO.sub.2 R where R is a lower alkyl group, (provided that when R.sup.1 is a group --CO.sub.2 R, R.sup.2 is a lower alkyl group) are disclosed.The compounds of formula (I) are useful as intermediates to compounds of other ring systems which are of pharmacological interest.Certain of the compounds of formula (I) are also useful as antimicrobial agents.Type: GrantFiled: September 17, 1979Date of Patent: November 25, 1980Assignee: Burroughs Wellcome Co.Inventors: Robert W. Morrison, Jr., William R. Mallory, Virgil L. Styles
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Patent number: 4225710Abstract: The present invention provides pyrimido(4,5-c)pyridazines, to methods for preparing them, formulations containing them and the preparation of such formulation and the use of such compounds in human therapy. These pyrimido(4,5-c)pyridazines of this invention are useful due to their activity as inhibitors of dihydropteroic and biosynthesis.Type: GrantFiled: July 7, 1978Date of Patent: September 30, 1980Assignee: Burroughs Wellcome Co.Inventors: Robert W. Morrison, Jr., William R. Mallory, Virgil L. Styles