Abstract: Techniques and tools are described for transmitting beacon messages using a wireless communication protocol, such as the Bluetooth Low Energy protocol. In some examples, beacon messages can be generated in a compact format and included in an AdvData portion of a payload of a protocol data unit of a Bluetooth Low Energy advertising channel packet. A beacon message can be transmitted from a stationary beacon generation device and broadcast to an area within a transmission range of the beacon generation device, and mobile computing devices, such as mobile phones, can receive the beacon message and perform one or more actions in response to information contained in the beacon message, all while conserving energy used by the beacon generation device and the mobile computing device.

Abstract: Voice call continuity is provided for calls that are carried over a hybrid network infrastructure in which access connections are distributed over loosely coupled network portions including a backend network such as a core VoIP (Voice over Internet Protocol) service network, one or more cellular mobile networks, and a public switched telephone network (“PSTN”). The calls are routed through the core VoIP network regardless of their points of origination or termination in other network portions so that signaling and call context are anchored in the core VoIP network. The conditions under which user equipment operate are continuously monitored so that when a connection is determined to have been unacceptably degraded or is likely to be interrupted, and/or a more optimal connection is available, a handover of the call to another connection is initiated so that call continuity is maintained using the lowest cost connection that provides acceptable call quality.

Abstract: A continual learning process is applied to a class of risk estimate-based algorithms and associated risk thresholds used for deciding when to initiate a handoff between different types of network connections that are available to a mobile device having telephony functionality. The process is implemented as a virtuous loop providing ongoing tuning and adjustment to improve call handoff algorithms and risk thresholds so that handoffs can be performed with the goals of minimizing dropped calls and unacceptable degradation in call quality as well as avoiding premature handoffs. Device characteristics, environmental context, connection measurements, and outcomes of call handoff decisions are crowd-sourced from a population of mobile devices into a cloud-based handoff decision enabling service.

Abstract: Voice call continuity is provided for calls that are carried over a hybrid network infrastructure in which access connections are distributed over loosely coupled network portions including a backend network such as a core VoIP (Voice over Internet Protocol) service network, one or more cellular mobile networks, and a public switched telephone network (“PSTN”). The calls are routed through the core VoIP network regardless of their points of origination or termination in other network portions so that signaling and call context are anchored in the core VoIP network. The conditions under which user equipment operate are continuously monitored so that when a connection is determined to have been unacceptably degraded or is likely to be interrupted, and/or a more optimal connection is available, a handover of the call to another connection is initiated so that call continuity is maintained using the lowest cost connection that provides acceptable call quality.

Abstract: Techniques and tools are described for transmitting beacon messages using a wireless communication protocol, such as the Bluetooth Low Energy protocol. In some examples, beacon messages can be generated in a compact format and included in an AdvData portion of a payload of a protocol data unit of a Bluetooth Low Energy advertising channel packet. A beacon message can be transmitted from a stationary beacon generation device and broadcast to an area within a transmission range of the beacon generation device, and mobile computing devices, such as mobile phones, can receive the beacon message and perform one or more actions in response to information contained in the beacon message, all while conserving energy used by the beacon generation device and the mobile computing device.

Abstract: The present invention is directed to a platform technology for quick and easy detection and identification of single or multiple microorganisms in a sample using peptide labeled oligonucleotides (PLONs). The PLONs are specifically designed to be complementary to certain nucleic acid sequences on a target microorganism. When the PLONs of the present invention are added to nucleic acids extracted from a sample (both biological and/or non-biological), they hybridize to the specific target nucleic acids of the microorganisms, and the PLONs are then detected with one or more specific enzymes coupled to antibodies that are specific to the conjugated peptides attached to the PLONs.

Abstract: The present invention provides a composition and prodrug for targeted drug delivery to the central nervous system of a patient. The inventive composition and prodrug include a pharmaceutically acceptable active agent and at least one protein selected from the group consisting of a fimbrial adhesin protein, a membrane protein, and combinations thereof. The inventive compositions and prodrugs of the present invention selectively target the blood-brain barrier and deliver hydrophilic and lipophilic active agents of varying sizes to the central nervous system.

Abstract: The present invention provides a isolated bacteriophage useful as a tool for studying biological, biochemical, physiological and genetic properties of actinomycetes and other organisms which comprises a novel strain of Saccharomonospora having certain specified characteristics. The invention also relates to a process for the isolation of the said bacteriophage and/or DNA phage and to a novel universal growth medium which is particularly useful in the said process. Another embodiment of the process relates to a clonong vector which comprises a plasmid or bacteriophage comprising the phage DNA of the invention.

Abstract: The present invention relates to a method for making recombinant Saccharomyces cerevisiae. The method includes the steps of amplifying one or more whiB-like genes of Mycobacteria by polymerase chain reaction (PCR), cloning the amplified one or more whiB-like genes into a plasmid, transforming the clone into an E. coli using a first shuttle vector, amplifying the clone, introducing the amplified clone into a second shuttle vector, introducing said second shuttle vector into Saccharomyces cerevisiae.

Abstract: The present invention provides a isolated bacteriophage useful as a tool for studying biological, biochemical, physiological and genetic properties of actinomycetes and other organisms which comprises a novel strain of Saccharomonospora having certain specified characteristics. The invention also relates to a process for the isolation of the said bacteriophage and/or DNA phage and to a novel universal growth medium which is particularly useful in the said process. Another embodiment of the process relates to a clonong vector which comprises a plasmid or bacteriophage comprising the phage DNA of the invention.

Abstract: The present invention provides a isolated bacteriophage useful as a tool for studying biological, biochemical, physiological and genetic properties of actinomycetes and other organisms which comprises a novel strain of Saccharomonospora having certain specified characteristics. The invention also relates to a process for the isolation of the said bacteriophage and/or DNA phage and to a novel universal growth medium which is particularly useful in the said process. Another embodiment of the process relates to a cloning vector which comprises a plasmid or bacteriophage comprising the phage DNA of the invention.

Abstract: The present invention relates to an in vivo drug screening method taking advantage of the yeast two-hybrid system provides a method of using the whiB genes which are regulatory genes of mycobacteria, whose functions have not been reported so far, as drug target by using the yeast Saccharomyces cerevisiae as a surrogate host.