Patents by Inventor Vishwanath R. Lingappa
Vishwanath R. Lingappa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230147603Abstract: Described herein are compounds, pharmaceutical compositions and methods of using these compounds and pharmaceutical compositions for treating and/or preventing conditions such as, for example, those caused by any viral family causing respiratory viral disease, including specifically coronaviruses and influenza viruses.Type: ApplicationFiled: October 24, 2022Publication date: May 11, 2023Inventors: Vishwanath R. Lingappa, Kumarapandian Paulvannan
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Publication number: 20230037538Abstract: The present invention relates to compounds expected to be useful in the prevention and/or treatment of diseases such as amyotrophic lateral sclerosis, frontotemporal dementia, chronic traumatic encephalopathy, Alzheimer's disease, frontotemporal lobar degeneration, multisystem proteinopathy and the like, a method for preventing or treating such diseases, and the like.Type: ApplicationFiled: June 23, 2022Publication date: February 9, 2023Inventors: Dennis Solas, Anatoliy Kitaygorodskyy, Kumar Paulvannan, Vishwanath R. Lingappa, Masato Yoshikawa, Masahiro Ito, Yuta Tanaka, Keiko Kakegawa, Tomohiro Ohashi, Takuto Kojima, Akinori Toita, Osamu Kubo, Fumiaki Kikuchi, Florian Pünner, Junsi Wang
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Publication number: 20210403477Abstract: Described herein are compounds, pharmaceutical compositions and methods of using these compounds and pharmaceutical compositions for treating and/or preventing conditions such as amyotrophic lateral sclerosis. These compounds and pharmaceutical compositions are also useful as antivirals and antimicrobial agents.Type: ApplicationFiled: June 30, 2021Publication date: December 30, 2021Inventors: Kumarapandian Paulvannan, Dennis Solas, Anatoliy Kitaygorodskyy, Vishwanath R. Lingappa
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Patent number: 10036755Abstract: The present invention provides compositions and methods of use in investigations of the formation of mulitprotein assemblies implicated in disease. Also provided are assays for screening candidate compounds of potential utility in preventing and/or treating such diseases by preventing the assembly of or disrupting the function of multiprotein assemblies.Type: GrantFiled: April 2, 2015Date of Patent: July 31, 2018Assignee: Prosetta Antiviral, Inc.Inventors: Vishwanath R. Lingappa, Debendranath Dey
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Publication number: 20170242027Abstract: The present invention provides compositions and methods of use in investigations of the formation of multiprotein assemblies implicated in disease. Also provided are assays for screening candidate compounds of potential utility in preventing and/or treating such diseases by preventing the assembly of or disrupting the function of multiprotein assemblies.Type: ApplicationFiled: February 9, 2017Publication date: August 24, 2017Inventors: Vishwanath R. Lingappa, Debendranath Dey
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Publication number: 20170159097Abstract: The invention provides a cell-free system comprising not more than about 5% wheat germ extract for expressing proteins such as viral proteins and proteins required for viral capsid assembly, and proteins that assemble into multiprotein complexes in a manner analogous to viral capsids, are provided. Further provided are methods for expressing proteins such as viral proteins, proteins required for capsid assembly, and proteins that assemble into multiprotein complexes in a manner analogous to viral capsids using a cell-free system comprising not more than about 5% wheat germ extract. Further provided are methods to assay for compounds that modulate viral protein, viral capsid assembly, and assembly of proteins into multiprotein complexes whose disruption can ameliorate bacterial, parasitic, metabolic, oncologic, immunologic, or CNS disease in a cell-free system comprising not more than about 5% wheat germ extract.Type: ApplicationFiled: February 8, 2017Publication date: June 8, 2017Inventor: Vishwanath R. Lingappa
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Publication number: 20150226748Abstract: The present invention provides compositions and methods of use in investigations of the formation of mulitprotein assemblies implicated in disease. Also provided are assays for screening candidate compounds of potential utility in preventing and/or treating such diseases by preventing the assembly of or disrupting the function of multiprotein assemblies.Type: ApplicationFiled: April 2, 2015Publication date: August 13, 2015Inventors: Vishwanath R. Lingappa, Debendranath Dey
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Publication number: 20140106365Abstract: The present invention provides compositions and methods of use in investigations of the formation of multiprotein assemblies implicated in disease. Also provided are assays for screening candidate compounds of potential utility in preventing and/or treating such diseases by preventing the assembly of or disrupting the function of multiprotein assemblies.Type: ApplicationFiled: July 24, 2013Publication date: April 17, 2014Applicant: Prosetta Antiviral, Inc.Inventors: Vishwanath R. LINGAPPA, Debendranath Dey
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Publication number: 20130053267Abstract: The invention provides a cell-free system comprising not more than about 5% wheat germ extract for expressing proteins such as viral proteins and proteins required for viral capsid assembly, and proteins that assemble into multiprotein complexes in a manner analogous to viral capsids, are provided. Further provided are methods for expressing proteins such as viral proteins, proteins required for capsid assembly, and proteins that assemble into multiprotein complexes in a manner analogous to viral capsids using a cell-free system comprising not more than about 5% wheat germ extract. Further provided are methods to assay for compounds that modulate viral protein, viral capsid assembly, and assembly of proteins into multiprotein complexes whose disruption can ameliorate bacterial, parasitic, metabolic, oncologic, immunologic, or CNS disease in a cell-free system comprising not more than about 5% wheat germ extract.Type: ApplicationFiled: August 3, 2012Publication date: February 28, 2013Applicant: PROSETTA ANTIVIRAL, INC.Inventor: Vishwanath R. LINGAPPA
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Publication number: 20120301904Abstract: The present invention provides compositions and methods of use in investigations of the formation of mulitprotein assemblies implicated in disease. Also provided are assays for screening candidate compounds of potential utility in preventing and/or treating such diseases by preventing the assembly of or disrupting the function of multiprotein assemblies.Type: ApplicationFiled: April 26, 2012Publication date: November 29, 2012Applicant: Prosetta Antiviral, IncInventors: Vishwanath R. Lingappa, Clarence R. Hurt, Debendranath Dey
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Patent number: 7932043Abstract: Methods of preparing monoclonal antibodies that differentially bind to a single conformer of a protein of interest are described. Passive immunization using these antibodies as well as use of conformer-specific antibodies as diagnostic reagents for the purpose of stratification of patient populations with regards to disease outcome, drug efficacy or drug sensitivity is also disclosed as well as active immunization with the protein conformer. In the screening techniques, detection can be for example by tissue immunostaining, western blotting or solution IP. A specific mab termed 7VC which shows conformation specificity to CtmPrP, a prion protein conformer that triggers neurodegeneration under specific assay conditions of pH and copper concentration, is described. A second specific antibody termed 19B10 shows conformation specificity for NtmPrP, a prion protein conformer that downregulates total PrP expression and effects cell differentiation.Type: GrantFiled: August 18, 2003Date of Patent: April 26, 2011Assignee: The University of California at San FranciscoInventors: Carsten Korth, Vishwanath R. Lingappa
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Patent number: 7638269Abstract: A cell-free method for translation and assembly of viral capsid and capsid intermediates is disclosed. Also disclosed are novel capsid assembly intermediates and novel host proteins which bind to such assembly intermediates. The invention also includes a screening method for compounds that alter viral capsid assembly, and a method of treating viral infection using compounds which inhibit the capsid assembly pathway.Type: GrantFiled: September 13, 2002Date of Patent: December 29, 2009Assignees: The Regents of the University of California, The University of WashingtonInventors: Jaisri R. Lingappa, Kevin C. Klein, Vishwanath R. Lingappa
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Publication number: 20080160507Abstract: A cell-free method for translation and assembly of retroviral, particularly HIV, capsid and capsid intermediates is disclosed. Also disclosed are novel HIV capsid assembly intermediates and novel host proteins which bind to such assembly intermediates. The invention also includes a screening method for compounds that alter retrovirus capsid assembly, and a method of treating HIV using compounds which inhibit the HIV capsid assembly pathway.Type: ApplicationFiled: September 20, 2007Publication date: July 3, 2008Inventors: Jaisri R. Lingappa, Vishwanath R. Lingappa
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Patent number: 7348134Abstract: A cell-free method for translation and assembly of retroviral, particularly HIV, capsid and capsid intermediates is disclosed. Also disclosed are novel HIV capsid assembly intermediates and novel host proteins which bind to such assembly intermediates. The invention also includes a screening method for compounds that alter retrovirus capsid assembly, and a method of treating HIV using compounds which inhibit the HIV capsid assembly pathway.Type: GrantFiled: January 17, 2003Date of Patent: March 25, 2008Assignee: The Regents of the University of CaliforniaInventors: Jaisri R. Lingappa, Vishwanath R. Lingappa
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Patent number: 7041462Abstract: Methods and compositions are provided for identifying novel conformers of proteins not known to exist as different conformers. By using chimeric genes replacing a native signal sequence with a different signal sequence resulting in the production of a conformer, one can compare the native protein with the product of the chimeric gene. Where the conformations are different, the different protein may be used for production of antibodies, elucidation of mechanisms associated with the native and different conformer protein, assays for the presence of the different conformer in physiological samples, identification of compounds specifically binding to the conformer, particularly drugs, etc. Where the formation of the conformer is associated with a diseased state, the conformer may be used in screens to identify compounds as drug candidates.Type: GrantFiled: August 3, 2004Date of Patent: May 9, 2006Assignee: Regents of the University of CaliforniaInventors: Vishwanath R. Lingappa, D. Thomas Rutkowski, Ramanujan S. Hegde
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Patent number: 6821742Abstract: Methods and compositions are provided for identifying novel conformers of proteins not known to exist as different conformers. By using chimeric genes replacing a native signal sequence with a different signal sequence resulting in the production of a conformer, one can compare the native protein with the product of the chimeric gene. Where the conformations are different, the different protein may be used for production of antibodies, elucidation of mechanisms associated with the native and different conformer protein, assays for the presence of the different conformer in physiological samples, identification of compounds specifically binding to the conformer, particularly drugs, etc. Where the formation of the conformer is associated with a diseased state, the conformer may be used in screens to identify compounds as drug candidates.Type: GrantFiled: December 15, 2000Date of Patent: November 23, 2004Assignee: Regents of the University of CaliforniaInventors: Vishwanath R. Lingappa, D. Thomas Rutkowski, Ramanujan S. Hegde
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Publication number: 20030153066Abstract: A cell-free method for translation and assembly of viral capsid and capsid intermediates is disclosed. Also disclosed are novel capsid assembly intermediates and novel host proteins which bind to such assembly intermediates. The invention also includes a screening method for compounds that alter viral capsid assembly, and a method of treating viral infection using compounds which inhibit the capsid assembly pathway.Type: ApplicationFiled: September 13, 2002Publication date: August 14, 2003Inventors: Jaisri R. Lingappa, Kevin C. Klein, Vishwanath R. Lingappa
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Publication number: 20030148496Abstract: A cell-free method for translation and assembly of retroviral, particularly HIV, capsid and capsid intermediates is disclosed. Also disclosed are novel HIV capsid assembly intermediates and novel host proteins which bind to such assembly intermediates. The invention also includes a screening method for compounds that alter retrovirus capsid assembly, and a method of treating HIV using compounds which inhibit the HIV capsid assembly pathway.Type: ApplicationFiled: January 17, 2003Publication date: August 7, 2003Inventors: Jaisri R. Lingappa, Vishwanath R. Lingappa
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Patent number: 6593103Abstract: A cell-free method for translation and assembly of retroviral, particularly HIV, capsid and capsid intermediates is disclosed. Also disclosed are novel HIV capsid assembly intermediates and novel host proteins which bind to such assembly intermediates. The invention also includes a screening method for compounds that alter retrovirus capsid assembly, and a method of treating HIV using compounds which inhibit the HIV capsid assembly pathway.Type: GrantFiled: February 6, 1998Date of Patent: July 15, 2003Assignee: The Regents of the University of CaliforniaInventors: Jaisri R. Lingappa, Vishwanath R. Lingappa
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Publication number: 20030104577Abstract: A cell-free method for translation and assembly of retroviral, particularly HIV, capsid and capsid intermediates is disclosed. Also disclosed are novel HIV capsid assembly intermediates and novel host proteins which bind to such assembly intermediates. The invention also includes a screening method for compounds that alter retrovirus capsid assembly, and a method of treating HIV using compounds which inhibit the HIV capsid assembly pathway.Type: ApplicationFiled: January 2, 2002Publication date: June 5, 2003Applicant: UC RegentsInventors: Vishwanath R. Lingappa, Jaisri R. Lingappa