Patents by Inventor Vishwas N. Joshi

Vishwas N. Joshi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detecting a target using a composite probe comprising a directing agent, a metal nanoparticle and an enzyme
    Patent number: 7892781
    Abstract: A test agent includes a composite probe having at least one nanoparticle having multiple metal atoms, a directing agent, and an enzyme. The directing agent attaches the probe to a target in a test sample. The test sample and bound probe are then treated with an enzyme substrate. A method of detecting a target in a test sample includes exposing the test sample to the probe, then treating the test sample with an enhancement or development solution to deposit at least one of a fluorophore, a chromogen, or a metal.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: February 22, 2011
    Assignee: Nanoprobes, Inc.
    Inventors: Richard D. Powell, Vishwas N. Joshi, James F. Hainfeld
  • Method for detecting a target using enzyme directed deposition of elemental metal
    Patent number: 7888060
    Abstract: Disclosed embodiments concern site-specific, enzymatic-directed deposition of elemental metal for in-situ analysis. Enzyme substrates are contacted with metal ions and subsequently direct the deposition of elemental metals. Sensitive and selective detection of target molecules, such as biomarkers in various biological samples, can be obtained using various methods, such as in-situ chromogenic immunohistochemical (IHC) detection with bright field light microscopy.
    Type: Grant
    Filed: March 4, 2008
    Date of Patent: February 15, 2011
    Assignee: Nanoprobes, Inc.
    Inventors: James F. Hainfeld, Wenqiu Liu, Richard D. Powell, Vishwas N. Joshi
  • Methods and reagents to increase the sensitivity of enzyme metallographic detection
    Publication number: 20080318249
    Abstract: A test agent includes a composite probe having at least one nanoparticle having multiple metal atoms, a directing agent, and an enzyme. The directing agent attaches the probe to a target in a test sample. The test sample and bound probe are then treated with an enzyme substrate. A method of detecting a target in a test sample includes exposing the test sample to the probe, then treating the test sample with an enhancement or development solution to deposit at least one of a fluorophore, a chromogen, or a metal.
    Type: Application
    Filed: April 28, 2008
    Publication date: December 25, 2008
    Inventors: Richard D. Powell, Vishwas N. Joshi, James F. Hainfeld
  • Metal-lipid molecules
    Patent number: 6121425
    Abstract: Novel metal-lipid molecules have the formula M-Or-L. M represents a cluster or colloid of atoms of Au, Ag, Pt, Pd, or combinations thereof. Or is an organic group covalently attached to the metal atoms. L represents a lipid moiety. In a preferred embodiment, M represents a cluster of about 50-70 gold atoms having a diameter of about 1.4 nm in diameter and L represents dipalmitoyl phosphatidyl ethanolamine.
    Type: Grant
    Filed: March 16, 1998
    Date of Patent: September 19, 2000
    Assignee: Nanoprobes, Inc.
    Inventors: James F. Hainfeld, Frederic R. Furuya, Richard D. Powell, Vishwas N. Joshi, Edmund Gutierrez