Patents by Inventor Vitezslav Bryja

Vitezslav Bryja has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 4-(1H-imidazol-5-yl)-1H-pyrrolo[2, 3-b] pyridines for use in the treatment of leukaemias, lymphomas and solid tumors
    Patent number: 11498920
    Abstract: Novel 4-(1H-imidazol-5-yl)-1H-pyrrolo[2,3-b]pyridine compounds that are useful in the treatment of lymphomas, leukaemias, and solid tumors.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: November 15, 2022
    Assignee: MASARYKOVA UNIVERZITA
    Inventors: Vitezslav Bryja, Pavlina Janovska, Michaela Gregorova, Vaclav Nemec, Prashant Khirsariya, Kamil Paruch
  • 4-(1H- IMIDAZOL- 5- YL) -1H-PYRROLO [2, 3-B] PYRIDINES FOR USE IN THE TREATMENT OF LEUKAEMIAS, LYMPHOMAS AND SOLID TUMORS
    Publication number: 20210040086
    Abstract: Novel 4-(1H-imidazol-5-yl)-1H-pyrrolo[2,3-b]pyridine compounds that are useful in the treatment of lymphomas, leukaemias, and solid tumors.
    Type: Application
    Filed: March 26, 2019
    Publication date: February 11, 2021
    Applicant: MASARYKOVA UNIVERZITA
    Inventors: Vitezslav BRYJA, Pavlina JANOVSKA, Michaela GREGOROVA, Vaclav NEMEC, Prashant KHIRSARIYA, Kamil PARUCH
  • CASEIN KINASE 1 INHIBITORS FOR THE TREATMENT OF B-CELL CHRONIC LYMPHOCYTIC|LEUKEMIA
    Publication number: 20150209354
    Abstract: Medicaments for the treatment of the B-cell chronic lymphocytic leukemia, which are inhibitors of casein kinase 1.
    Type: Application
    Filed: August 5, 2013
    Publication date: July 30, 2015
    Inventors: Vitezslav Bryja, Marketa Kaucka, Karla Plevova, Sarka Pavlova, Sarka Pospisilova, Alois Kozubik
  • Method of determination of diagnosis and prognosis in patients with B-cell chronic lymphocytic leukemia and oligonucleotides for use in this method
    Patent number: 9057106
    Abstract: The invention provides a method of determination of diagnosis and prognosis of B-cell chronic lymphocytic leukemia from a biological sample collected from the body of a patient, wherein the status of Wnt/PCP signaling pathway is determined. Within the framework of the present invention the relation of CLL and molecular signaling pathway Wnt/PCP the components of which are markedly up-regulated in B-lymphocytes of the patients suffering from CLL was identified. The status of the Wnt/PCP signaling pathway can be determined, e.g., by the determination of the expression of components of said signaling pathway or by the determination of migration of CLL cells in the gradient of a chemokine in the presence of the ligand of said signaling pathway. The invention also relates to suitable oligonucleotides for use in the method of determination of expression of the signaling pathway components.
    Type: Grant
    Filed: August 3, 2010
    Date of Patent: June 16, 2015
    Assignee: MASARYKOVA UNIVERZITA
    Inventors: Vitezslav Bryja, Pavel Krejci, Marketa Kaucka, Sarka Pospisilova, Jiri Mayer, Alois Kozubik, Karla Plevova, Jana Kotaskova
  • Method of Determination of Diagnosis and Prognosis in Patients with B-cell Chronic Lymphocytic Leukemia and Oligonucleotides for Use in this Method
    Publication number: 20120135419
    Abstract: The invention provides a method of determination of diagnosis and prognosis of B-cell chronic lymphocytic leukemia from a biological sample collected from the body of a patient, wherein the status of Wnt/PCP signaling pathway is determined. Within the framework of the present invention the relation of CLL and molecular signaling pathway Wnt/PCP the components of which are markedly up-regulated in B-lymphocytes of the patients suffering from CLL was identified. The status of the Wnt/PCP signaling pathway can be determined, e.g., by the determination of the expression of components of said signaling pathway or by the determination of migration of CLL cells in the gradient of a chemokine in the presence of the ligand of said signaling pathway. The invention also relates to suitable oligonucleotides for use in the method of determination of expression of the signaling pathway components.
    Type: Application
    Filed: August 3, 2010
    Publication date: May 31, 2012
    Applicant: MASARYKOVA UNIVERZITA
    Inventors: Vitezslav Bryja, Pavel Krejci, Marketa Kaucka, Sarka Pospisilova, Jiri Mayer, Alois Kozubik, Karla Plevova, Jana Kotaskova