Patents by Inventor Vito Ruggiero

Vito Ruggiero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Myd88 Homodimerization Inhibitors
    Publication number: 20080064643
    Abstract: The present invention relates to peptidic and peptidomimetic compounds with the formula (X?)AA1-AA2-AA3-AA4-AA5-AA6-AA7 in which the various groups are defined in the description here below, which mimic a particular protein portion of MyD88, preventing its homodimerisation and interfering with its interaction with the TIR domain. The present invention also provides procedures for the preparation of said compounds, pharmaceutical compositions containing them and their use as medicaments, particularly for the treatment of inflammatory and autoimmune diseases.
    Type: Application
    Filed: December 16, 2005
    Publication date: March 13, 2008
    Inventors: Paolo Carminati, Grazia Gallo, Nicola Fanto, Vito Ruggiero, Marica Sassano, Domenico Mastroianni
  • Use of 6,7-substituted 2-aminotetralines suitable for preparing a pharmaceutical composition for the therapeutic treatment of inflammatory and/or autoimmune pathologies
    Patent number: 6242497
    Abstract: 6,7-substituted 2-aminotetralines are used to treat inflammatory and/or autoimmune conditions induced by inflammatory cytokines.
    Type: Grant
    Filed: March 22, 2000
    Date of Patent: June 5, 2001
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p. A.
    Inventors: Piero Foresta, Vito Ruggiero
  • Esters of acyl L-carnitines and pharmaceutical compositions containing same for treating endotoxic shock
    Patent number: 6180667
    Abstract: Esters of alkanoyl L-carnitines wherein the alkanoyl is a saturated or unsaturated, staight or branched alkanoyl having 2-26 carbon atoms, optionally &ohgr;-substituted with trialkylammonium, dialkylsulfonium, hydroxyl, carboxyl, halogen, methanesulfonyl and hydroxysulfonyl, are useful for preparing pharmaceutical compositions for the treatment of endotoxic shock.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: January 30, 2001
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Piero Foresta, Vito Ruggiero, Maria Ornella Tinti, Nazareno Scafetta
  • Esters of acyl L-carnitines and pharmaceutical compositons containing same for treating endotoxic shock
    Patent number: 5625085
    Abstract: Esters of alkanoyl L-carnitines wherein the alkanoyl is a saturated or unsaturated, straight or branched alkanoyl having 2-26 carbon atoms, optionally .omega.-substituted with trialkylammonium, dialkylsulfonium, hydroxyl, carboxyl, halogen, methanesulfonyl and hydroxysulfonyl, are useful for preparing pharmaceutical compositions for the treatment of endotoxic shock.
    Type: Grant
    Filed: July 14, 1994
    Date of Patent: April 29, 1997
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Piero Foresta, Vito Ruggiero, Maria O. Tinti, Nazareno Scafetta
  • Use of 6,7-substituted-2-aminotetralines for preparing pharmaceutical compositions useful for the treatment of septic shock, and antipyretic and antiinflammatory pharmaceutical compositions
    Patent number: 5591777
    Abstract: The use of 6,7-substituted-2-aminotetralines (e.g. 2-amino-6-fluoro-7-methoxytetraline) is disclosed for preparing pharmaceutical compositions useful for the treatment of septic shock and having antiinflammatory and antipyretic activities.
    Type: Grant
    Filed: February 27, 1996
    Date of Patent: January 7, 1997
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Piero Foresta, Vito Ruggiero