Patents by Inventor Vittorio Bellotti
Vittorio Bellotti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230357134Abstract: The present invention relates to compounds for stabilising the native tetrameric form of transthyretin and protecting it from proteolytic cleavage; compounds for use in the prevention and treatment of transthyretin amyloidosis; and agents and medicaments comprising such compounds. The compounds are based on a general structure A-L-B, wherein A is a group of formula (II) or of formula (III): or of formula (IV) or of formula (V) B is a group of formula (III), (IV), or (V), or a group of formula (VI) or a group of formula —R10Z, wherein: Z is selected from —CO2R?, —CONR?R?, —SO2R? wherein R? and R? are independently H or C1-C4 alkyl; and R10 is a C1-C4 alkylene or alkenylene group; and L represents a linker group which is a saturated or unsaturated chain of 5 to 13 carbon atoms.Type: ApplicationFiled: September 16, 2021Publication date: November 9, 2023Inventors: Vittorio BELLOTTI, Alessandra CORAZZA, Palma Patrizia MANGIONE, Mark Brian PEPYS, Christopher SWAIN, Graham Walter TAYLOR
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Publication number: 20130331327Abstract: This invention relates to the specific Asp76Asn (D76N) variant ?2-microglobulin (?2M) protein, nucleic acids encoding the same, their characterization and applications in studying amyloid fibrillogenesis, including diagnostic and therapeutic applications.Type: ApplicationFiled: June 8, 2012Publication date: December 12, 2013Inventors: Vittorio Bellotti, Sophie Valleix, Mark Brian Pepys, Madeleine M. Riès-Kautt
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Patent number: 8410199Abstract: The present invention provides polymeric compositions containing thermoplastic starch and a thermoplastic polymer incompatible with starch, in which the starch constitutes the dispersed phase and the thermoplastic polymer constitutes the continuous phase, selected: A) from compositions comprising an agent with an interfacial effect selected from esters of polyols with mono- or polycarboxylic acids with dissociation constants within certain limits, the esters having specific values of the hydrophilic/lipophilic balance index HLB or being amongst the non-ionic surfactants which are soluble in water but cannot significantly be extracted by water from the compositions which contain them; B) from compositions wherein the thermoplastic polymer is an aliphatic or aliphatic-aromatic copolyester wherein the ratio (R) between the average viscometric molecular weight and the melt index is greater than 25,000 and C) from compositions wherein the thermoplastic polymer is selected from aliphatic-aromatic copolyesters, polyType: GrantFiled: January 25, 2007Date of Patent: April 2, 2013Assignee: Novamont S.p.A.Inventors: Catia Bastioli, Vittorio Bellotti, Gian Domenico Cella, Luciano Del Giudice, Sandro Montino, Gabriele Perego
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Patent number: 8236984Abstract: The present invention relates to compounds of formula (I) for stabilizing the tetrameric form of transthyretin, compounds for use in the treatment or prevention of amyloidosis, and agents and medicaments comprising such compounds. wherein X, Y, R1, R2, R3, R4, m, n, p, q, and the linker are as defined herein.Type: GrantFiled: March 22, 2010Date of Patent: August 7, 2012Assignee: Pentraxin Therapeutics Ltd.Inventors: Mark Brian Pepys, Steven Victor Ley, Angus John Morrison, Vittorio Bellotti, Simon Kolstoe, Martin Smith
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Patent number: 7956107Abstract: The present invention provides polymeric compositions containing thermoplastic starch and a thermoplastic polymer incompatible with starch, in which the starch constitutes the dispersed phase and the thermoplastic polymer constitutes the continuous phase, selected: A) from compositions comprising an agent with an interfacial effect selected from esters of polyols with mono- or polycarboxylic acids with dissociation constants within certain limits, the esters having specific values of the hydrophilic/lipophilic balance index HLB or being amongst the non-ionic surfactants which are soluble in water but cannot significantly be extracted by water from the compositions which contain them; B) from compositions wherein the thermoplastic polymer is an aliphatic or aliphatic-aromatic copolyester wherein the ratio (R) between the average viscometric molecular weight and the melt index is greater than 25,000 and C) from compositions wherein the thermoplastic polymer is selected from aliphatic-aromatic copolyesters, polyType: GrantFiled: January 25, 2007Date of Patent: June 7, 2011Assignee: Novamont S.p.A.Inventors: Catia Bastioli, Vittorio Bellotti, Gian Domenico Cella, Luciano Del Giudice, Sandro Montino, Gabriele Perego
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Publication number: 20100249233Abstract: The present invention relates to compounds of formula (I) for stabilizing the tetrameric form of transthyretin, compounds for use in the treatment or prevention of amyloidosis, and agents and medicaments comprising such compounds. wherein X, Y, R1, R2, R3, R4, m, n, p, q, and the linker are as defined herein.Type: ApplicationFiled: March 22, 2010Publication date: September 30, 2010Inventors: Mark Brian PEPYS, Steven Victor Ley, Angus John Morrison, Vittorio Bellotti, Stephen Wood, Simon Kolstoe, Martin Smith
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Publication number: 20070129468Abstract: The present invention provides polymeric compositions containing thermoplastic starch and a thermoplastic polymer incompatible with starch, in which the starch constitutes the dispersed phase and the thermoplastic polymer constitutes the continuous phase, selected: A) from compositions comprising an agent with an interfacial effect selected from esters of polyols with mono- or polycarboxylic acids with dissociation constants within certain limits, the esters having specific values of the hydrophilic/lipophilic balance index HLB or being amongst the non-ionic surfactants which are soluble in water but cannot significantly be extracted by water from the compositions which contain them; B) from compositions wherein the thermoplastic polymer is an aliphatic or aliphatic-aromatic copolyester wherein the ratio (R) between the average viscometric molecular weight and the melt index is greater than 25,000 and C) from compositions wherein the thermoplastic polymer is selected from aliphatic-aromatic copolyesters, polyType: ApplicationFiled: January 25, 2007Publication date: June 7, 2007Inventors: Catia Bastioli, Vittorio Bellotti, Gian Cella, Luciano Del Giudice, Sandro Montino, Gabriele Perego
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Publication number: 20070123612Abstract: The present invention provides polymeric compositions containing thermoplastic starch and a thermoplastic polymer incompatible with starch, in which the starch constitutes the dispersed phase and the thermoplastic polymer constitutes the continuous phase, selected: A) from compositions comprising an agent with an interfacial effect selected from esters of polyols with mono- or polycarboxylic acids with dissociation constants within certain limits, the esters having specific values of the hydrophilic/lipophilic balance index HLB or being amongst the non-ionic surfactants which are soluble in water but cannot significantly be extracted by water from the compositions which contain them; B) from compositions wherein the thermoplastic polymer is an aliphatic or aliphatic-aromatic copolyester wherein the ratio (R) between the average viscometric molecular weight and the melt index is greater than 25,000 and C) from compositions wherein the thermoplastic polymer is selected from aliphatic-aromatic copolyesters, polyType: ApplicationFiled: January 25, 2007Publication date: May 31, 2007Inventors: Catia Bastioli, Vittorio Bellotti, Gian Cella, Luciano Giudice, Sandro Montino, Gabriele Perego
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Patent number: 7176251Abstract: The present invention provides polymeric compositions containing thermoplastic starch and a thermoplastic polymer incompatible with starch, in which the starch constitutes the dispersed phase and the thermoplastic polymer constitutes the continuous phase, selected: A) from compositions comprising an agent with an interfacial effect selected from esters of polyols with mono- or polycarboxylic acids with dissociation constants within certain limits, the esters having specific values of the hydrophilic/lipophilic balance index HLB or being amongst the non-ionic surfactants which are soluble in water but cannot significantly be extracted by water from the compositions which contain them; B) from compositions wherein the thermoplastic polymer is an aliphatic or aliphatic-aromatic copolyester wherein the ratio (R) between the average viscometric molecular weight and the melt index is greater than 25,000 and C) from compositions wherein the thermoplastic polymer is selected from aliphatic-aromatic copolyesters, polyType: GrantFiled: November 5, 1997Date of Patent: February 13, 2007Assignee: Novamont S.p.A.Inventors: Catia Bastioli, Vittorio Bellotti, Gian Domenico Cella, Luciano Del Giudice, Sandro Montino, Gabriele Perego
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Patent number: 6962950Abstract: Hydrophobic polymers incompatible with starch containing, as a filler, a starch complex dispersed in the polymer matrix in the form of particles with numeric mean dimension of less than 3 microns, bound to the polymer matrix by coupling agents containing groups compatible with the matrix and with the complex, in which the starch complex is characterized by second-derivative IR absorption in the region of 940-952 cm?1 are described or wherein the starch complex is bound to the polymeric matrix through reactive groups contained in the complex capable of being fixed to the polymeric matrix. The starch complex in the case of biodegradable polymers such as the aliphatic or aliphatic aromatic polyesters is formed with complexing agents different from the polymer forming the matrix and from EVOH copolymers.Type: GrantFiled: September 22, 1999Date of Patent: November 8, 2005Assignee: Novamont S.p.A.Inventors: Catia Bastioli, Vittorio Bellotti, Alessandro Montino
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Patent number: 6506824Abstract: Biodegradable thermoplastic compositions comprising a starch component, a cellulose ester or ether, a plasticizer for the starchy phase and of the cellulose and derivatives, and a compatibilizer agent selected from polymers compatible with the cellulose and or starchy component, grafted with aliphatic or polyhydroxilated chains; copolymers obtained from hydroxy acids and/or diamines with 2-24C and aliphatic or aromatic diisocyanates; copolymers obtained from aliphatic polyesters, polyureas and polyalkylene glycols and aliphatic or aromatic diisocyanates; copolymers obtained from polymers compatible with cellulose ester or ethers and/or the starchy component by grafting starch soluble polyols; polymer capable of complexing starch; starch compatible polyols.Type: GrantFiled: October 17, 1997Date of Patent: January 14, 2003Assignee: Novamont S.p.A.Inventors: Catia Bastioli, Vittorio Bellotti, Roberto Lombi, Gabriele Perego
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Patent number: 6348524Abstract: Heterophasic compositions comprising starch and a thermoplastic polymer that is incompatible with the starch, in which the starch constitutes the discontinuous phase and the thermoplastic polymer the continuous matrix, having an impact strength greater than 30 KJ/m2 (measured on blown film of 30 microns thick at 10° C. and RH less than 5%), and further characterised by the presence in the X-ray diffraction spectrum of a peak at an angle 2-theta from 13 to 14° the ratio of the intensity of which to that of the peak of the amorphous starch which occurs at 20.5°, is less than 2 and greater than 0.02.Type: GrantFiled: June 17, 1999Date of Patent: February 19, 2002Assignee: Novamont S.p.A.Inventors: Catia Bastioli, Vittorio Bellotti, Gianfranco Del Tredici, Italo Guanella, Roberto Lombi
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Publication number: 20020006989Abstract: Heterophasic compositions comprising starch and a thermoplastic polymer that is incompatible with the starch, in which the starch constitutes the discontinuous phase and the thermoplastic polymer the continuous matrix, having an impact strength greater than 30 KJ/m2 (measured on blown film of 30 microns thick at 10° C. and RH less than 5%), and further characterised by the presence in the X-ray diffraction spectrum of a peak at an angle 2-theta from 13 to 14° the ratio of the intensity of which to that of the peak of the amorphous starch which occurs at 20.5°, is less than 2 and greater than 0.02.Type: ApplicationFiled: June 17, 1999Publication date: January 17, 2002Inventors: CATIA BASTIOLI, VITTORIO BELLOTTI, GIANFRANCO DEL TREDICI, ITALO GUANELLA, ROBERTO LOMBI
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Patent number: 6277899Abstract: A polymeric composition comprising a filler melt-dispersed in a matrix comprising, a destructurized starch component; a synthetic thermoplastic polymeric component selected from the group consisting of polyvinylalcohol, polyvinyl acetate, thermoplastic polyesters and graft copolymers of polysaccharides; and a fluidizing agent selected from the group consisting of C12-C22 fatty acids, C12-C22 fatty alcohols, esters and amides of said fatty acids, polyolefin waxes, polyglycol ethers of alditols, polyglycerols esterified with C12-C22 fatty acids, and mixtures thereof, wherein said filler is a mixture of an inorganic filler and a filler of organic nature, wherein the organic filler is present in an amount from 5% to 70% by weight.Type: GrantFiled: October 27, 1999Date of Patent: August 21, 2001Assignee: Novamont S.p.A.Inventors: Catia Bastioli, Vittorio Bellotti, Roberto Lombi, Matteo Nicolini
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Patent number: 5874486Abstract: A polymeric composition comprises a matrix including a starch component and at least one synthetic thermoplastics polymeric component in which a filler is dispersed, characterised in that the matrix includes a fluidising agent selected from the group consisting of C.sub.12 -C.sub.22 fatty acids, C.sub.12 -C.sub.22 fatty alcohols, esters and amides of the said fatty acids, poly and polyglycol ethers of alditols or polyglycerols esterified with the said fatty acids and their mixtures and the said filler comprises natural fillers of an organic nature dispersed in the matrix in quantities of from 5% to 70% by weight with reference to the total weight of the composition.Type: GrantFiled: March 27, 1995Date of Patent: February 23, 1999Assignee: Novamont S.p.A.Inventors: Catia Bastioli, Vittorio Bellotti, Roberto Lombi, Matteo Nicolini
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Patent number: 5801207Abstract: Biodegradable foamed articles having density comprised from 5 to 300 kg/m.sup.3 obtained by agglomeration of foamed particles having composition comprising a thermoplastic starchy material or a thermoplastic natural polymer capable of absorbing water when converted into the thermoplastic state, a thermoplastic polymer, and water.Type: GrantFiled: September 6, 1996Date of Patent: September 1, 1998Assignee: Novamont S.p.A.Inventors: Catia Bastioli, Vittorio Bellotti, Gianfranco Del Tredici, Angelos Rallis
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Patent number: 5736586Abstract: Biodegradable foamed plastic material having a bulk density comprised within the range of from 5 to 13 kg/m.sup.3, comprising:30-99.5 by weight of polisaccharide containing more than 50% of thermoplastic starch or starch complexed by polimeric structures, having an intrinsic viscosity (in DMSO) lower than 1.3 dl/g and less than 20% by weight of soluble fraction in ethanol;0.5-70% by weight of a thermoplastic polymer which is soluble in starch, or is capable of complexing it;0-20% by weight of water.The material can be used as a loose filler or for other foamed articles.Type: GrantFiled: August 8, 1995Date of Patent: April 7, 1998Assignee: Novamont S.p.A.Inventors: Catia Bastioli, Vittorio Bellotti, Gianfranco Del Tredici, Alessandro Montino, Roberto Ponti
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Patent number: 5589518Abstract: Biodegradable foamed articles having density comprised from 5 to 300 kg/m.sup.3 obtained by agglomeration of foamed particles having composition comprising a thermoplastic starchy material or a thermoplastic natural polymer capable of absorbing water when converted into the thermoplastic state, a thermoplastic polymer, and water.Type: GrantFiled: June 6, 1995Date of Patent: December 31, 1996Assignee: Novamont S.p.A.Inventors: Catia Bastioli, Vittorio Bellotti, Gianfranco Del Tredici, Angelos Rallis
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Patent number: 5534150Abstract: A selectively-permeable membrane constituted by a composition comprising starch and a synthetic thermoplastic polymer is used for separating liquid aqueous-organic mixtures by pervaporation.Type: GrantFiled: May 17, 1994Date of Patent: July 9, 1996Assignee: Novamont S.P.A.Inventors: Catia Bastioli, Vittorio Bellotti
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Patent number: 5462981Abstract: The method of producing plasticized polyvinyl alcohol by mixing polyvinyl alcohol in the presence of an organic plasticizer and water in a quantity which is insufficient to dissolve the polyvinyl alcohol under normal conditions, includes the steps of:i) pre-plasticizing the polyvinyl alcohol at a maximum temperature no higher than its softening point so as to produce a pre-plasticized polyvinyl alcohol having a melting point below the softening point of the polyvinyl alcohol used, andii) further processing the pre-plasticized polyvinyl alcohol thus produced at a temperature above its melting point, under shear-stress conditions and for a period of time to produce a substantially homogeneous melt.Type: GrantFiled: July 25, 1994Date of Patent: October 31, 1995Assignee: Novamont S.p.A.Inventors: Catia Bastioli, Vittorio Bellotti, Gianfranco Del Tredici, Roberto Ponti