Patents by Inventor Viviane Van Dorsselaer
Viviane Van Dorsselaer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9102628Abstract: The invention relates to derivatives of pyrazole 3,5-carboxylates, of general formula (I): in which R1, R2, R3, R4, R5, X, Y, V, W and n are as defined herein. The invention also relates to salts of these compounds as well as hydrates or of solvates, enantiomers, diastereoisomers and mixtures thereof. Also disclosed are the methods of preparation and application in therapeutics of compounds of formula (I).Type: GrantFiled: December 24, 2009Date of Patent: August 11, 2015Assignee: SANOFIInventors: Yann Foricher, Martin Smrcina, Viviane Van Dorsselaer, Fabienne Weber
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Patent number: 7879889Abstract: The present invention discloses and claims therapeutic uses of a compound corresponding to the general formula (I): Wherein, X, R1, R2, R3, R4, R5, R5?, R6 and n are as described herein.Type: GrantFiled: June 22, 2009Date of Patent: February 1, 2011Assignee: Sanofi-AventisInventors: Pierre Despey-Roux, Daniel Frehel, Bruno Schoentjes, Viviane Van Dorsselaer
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Patent number: 7795289Abstract: This invention discloses and claims a method of treatment of a disease as defined herein using a compound conforming to the general formula (I): Wherein R1, R2, R?2, R3, R4 and R5 are as described herein. Specifically, the compounds of the present invention exhibit an inhibitory effect on the production of ?-amyloid peptide (?-A4) by inhibition of gamma protease. Therefore, the compounds of the present invention are useful in the treatment of pathologies such as senile dementia, Alzheimer's disease, Down's syndrome, Parkinson's disease, amyloid angiopathy and/or cerebrovascular disorders.Type: GrantFiled: September 21, 2007Date of Patent: September 14, 2010Assignee: Sanofi-AventisInventors: Sylvie Baltzer, Bruno Schoentjes, Viviane Van Dorsselaer
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Patent number: 7759377Abstract: Compounds of formula (I) as defined herein: inhibit the formation of the ?-amyloid peptide (?-A4) and are, therefore, useful in the treatment of pathologies in which a ?-amyloid peptide (?-A4) formation inhibitor provides a therapeutic benefit. Particular such pathologies are senile dementia, Alzheimer's disease, Down's syndrome, Parkinson's disease, amyloid angiopathy, cerebrovascular disorders, frontotemporal dementias and Pick's disease, post-traumatic dementias, pathologies linked to neuroinflammatory processes, Huntington's disease and Korsakov's syndrome.Type: GrantFiled: March 20, 2008Date of Patent: July 20, 2010Assignee: Sanofi-AventisInventors: Sylvie Baltzer, Marc Pascal, Viviane Van Dorsselaer
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Publication number: 20100160377Abstract: The invention relates to derivatives of pyrazole 3,5-carboxylates, of general formula (I): in which R1, R2, R3, R4, R5, X, Y, V, W and n are as defined herein. The invention also relates to salts of these compounds as well as hydrates or of solvates, enantiomers, diastereoisomers and mixtures thereof. Also disclosed are the methods of preparation and application in therapeutics of compounds of formula (I).Type: ApplicationFiled: December 24, 2009Publication date: June 24, 2010Applicant: SANOFI-AVENTISInventors: Yann FORICHER, Martin SMRCINA, Viviane VAN DORSSELAER, Fabienne WEBER
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Publication number: 20090253753Abstract: The present invention discloses and claims therapeutic uses of a compound corresponding to the general formula (I): Wherein, X, R1, R2, R3, R4, R5, R5?, R6 and n are as described herein.Type: ApplicationFiled: June 22, 2009Publication date: October 8, 2009Applicant: SANOFI-AVENTISInventors: Pierre DESPEYROUX, Daniel FREHEL, Bruno SCHOENTJES, Viviane VAN DORSSELAER
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Patent number: 7582664Abstract: The invention relates to a compound of formula (I): Wherein R1, R2, R2?, R3, R4 and R5 are as defined herein. The invention also relates to the use of said compound in therapeutics.Type: GrantFiled: July 7, 2006Date of Patent: September 1, 2009Assignee: Sanofi-AventisInventors: Sylvie Baltzer, Viviane Van Dorsselaer
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Patent number: 7563903Abstract: Compound corresponding to the general formula (I): in which, X represents an oxygen or sulphur atom; R1 represents a C1-10 alkyl group optionally substituted, a C3-7 cycloalkyl, thienyl, pyridinyl or pyrimidinyl group; the thienyl groups being optionally substituted; the phenyl group being optionally substituted; R2 represents a C1-6 alkyl group optionally substituted, a C3-7 cycloalkyl, piperidinyl, phenyl or pyridinyl group; the C3-7 cycloalkyl and piperidinyl groups being optionally substituted; the phenyl and pyridinyl groups being optionally substituted; R3 represents a hydrogen atom or a C1-6 alkyl group optionally substituted with a C3-7 cycloalkyl group; R4 represents a hydrogen atom or a C1-6 alkyl group; R5 and R5? represent, independently of each other, a hydrogen or halogen atom, a hydroxyl or C1-3 alkyl group; or R5 and R5? form together an oxo or oxime group such as: where R7 represents a hydrogen atom or a C1-3 alkyl; n represents an integer ranging from 0 to 3; and R6 represents, inType: GrantFiled: July 21, 2005Date of Patent: July 21, 2009Assignee: Sanofi-AventisInventors: Pierre Despeyroux, Daniel Frehel, Bruno Schoentjes, Viviane Van Dorsselaer
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Publication number: 20080176911Abstract: Compounds of formula (I) as defined herein: inhibit the formation of the ?-amyloid peptide (?-A4) and are, therefore, useful in the treatment of pathologies in which a ?-amyloid peptide (?-A4) formation inhibitor provides a therapeutic benefit. Particular such pathologies are senile dementia, Alzheimer's disease, Down's syndrome, Parkinson's disease, amyloid angiopathy, cerebrovascular disorders, frontotemporal dementias and Pick's disease, post-traumatic dementias, pathologies linked to neuroinflammatory processes, Huntington's disease and Korsakov's syndrome.Type: ApplicationFiled: March 20, 2008Publication date: July 24, 2008Applicant: SANOFI-AVENTISInventors: Sylvie BALTZER, Marc PASCAL, Viviane VAN DORSSELAER
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Patent number: 7371770Abstract: Compounds of formula (I) as defined herein: inhibit the formation of the ?-amyloid peptide (?-A4) and are, therefore, useful in the treatment of pathologies in which a ?-amyloid peptide (?-A4) formation inhibitor provides a therapeutic benefit. Particular such pathologies are senile dementia, Alzheimer's disease, Down's syndrome, Parkinson's disease, amyloid angiopathy, cerebrovascular disorders, frontotemporal dementias and Pick's disease, post-traumatic dementias, pathologies linked to neuroinflammatory processes, Huntington's disease and Korsakov's syndrome.Type: GrantFiled: July 14, 2006Date of Patent: May 13, 2008Assignee: SanofiaventisInventors: Sylvie Baltzer, Marc Pascal, Viviane Van Dorsselaer
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Publication number: 20080051436Abstract: This invention discloses and claims a method of treatment of a disease as defined herein using a compound conforming to the general formula (I): Wherein R1, R2, R?2, R3, R4 and R5 are as described herein. Specifically, the compounds of the present invention exhibit an inhibitory effect on the production of ?-amyloid peptide (?-A4) by inhibition of gamma protease. Therefore, the compounds of the present invention are useful in the treatment of pathologies such as senile dementia, Alzheimer's disease, Down's syndrome, Parkinson's disease, amyloid angiopathy and/or cerebrovascular disorders.Type: ApplicationFiled: September 21, 2007Publication date: February 28, 2008Applicant: SANOFI-AVENTISInventors: Sylvie BALTZER, Bruno SCHOENTJES, Viviane VAN DORSSELAER
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Patent number: 7291636Abstract: This invention discloses and claims a compound conforming to the general formula (I): Wherein R1, R2, R?2, R3, R4 and R5 are as described herein. The compounds of the present invention exhibit an inhibitory effect on the production of ?-amyloid peptide (?-A4) by inhibition of gamma protease. Therefore, the compounds of the present invention are useful in the treatment of pathologies such as senile dementia, Alzheimer's disease, Down's syndrome, Parkinson's disease, amyloid angiopathy and/or cerebrovascular disorders.Type: GrantFiled: January 14, 2005Date of Patent: November 6, 2007Assignee: Sanofi-AventisInventors: Sylvie Baltzer, Bruno Schoentjes, Viviane Van Dorsselaer
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Publication number: 20060293366Abstract: Compounds of formula (I) as defined herein: inhibit the formation of the ?-amyloid peptide (?-A4) and are, therefore, useful in the treatment of pathologies in which a ?-amyloid peptide (?-A4) formation inhibitor provides a therapeutic benefit. Particular such pathologies are senile dementia, Alzheimer's disease, Down's syndrome, Parkinson's disease, amyloid angiopathy, cerebrovascular disorders, frontotemporal dementias and Pick's disease, post-traumatic dementias, pathologies linked to neuroinflammatory processes, Huntington's disease and Korsakov's syndrome.Type: ApplicationFiled: July 14, 2006Publication date: December 28, 2006Applicant: SANOFI-AVENTISInventors: Sylvie Baltzer, Marc Pascal, Viviane Van Dorsselaer
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Publication number: 20060293365Abstract: The invention relates to a compound of formula (I): Wherein R1, R2, R2?, R3, R4 and R5 are as defined herein. The invention also relates to the use of said compound in therapeutics.Type: ApplicationFiled: July 7, 2006Publication date: December 28, 2006Applicant: SANOFI-AVENTISInventors: Sylvie BALTZER, Viviane VAN DORSSELAER
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Publication number: 20060052426Abstract: Compound corresponding to the general formula (I): in which, X represents an oxygen or sulphur atom; R1 represents a C1-10 alkyl group optionally substituted, a C3-7 cycloalkyl, thienyl, pyridinyl or pyrimidinyl group; the thienyl groups being optionally substituted; the phenyl group being optionally substituted; R2 represents a C1-6 alkyl group optionally substituted, a C3-7 cycloalkyl, piperidinyl, phenyl or pyridinyl group; the C3-7 cycloalkyl and piperidinyl groups being optionally substituted; the phenyl and pyridinyl groups being optionally substituted; R3 represents a hydrogen atom or a C1-6 alkyl group optionally substituted with a C3-7 cycloalkyl group; R4 represents a hydrogen atom or a C1-6 alkyl group; R5 and R5? represent, independently of each other, a hydrogen or halogen atom, a hydroxyl or C1-3 alkyl group; or R5 and R5? form together an oxo or oxime group such as: where R7 represents a hydrogen atom or a C1-3 alkyl; n represents an integer ranging from 0 to 3; and R6 represents, indeType: ApplicationFiled: July 21, 2005Publication date: March 9, 2006Inventors: Pierre Despeyroux, Daniel Frehel, Bruno Schoentjes, Viviane Van Dorsselaer
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Patent number: 6979683Abstract: The invention relates to benzimidazole derivatives of general formula (I) in which X represents a nitrogen atom or a carbon atom; and when X represents a nitrogen atom R3 represents in particular a hydrogen atom or a (C1-C4)alkyl group, R4 represents in particular a hydrogen atom; a (C1-C6)alkyl; (C3-C7)cycloalkyl; 4-piperidyl; —(CH2)p—NR5R6; —(CH2)p—CONR5R6; —CO—(CH2)p—NR5R6; —(CH2)p-phenyl; —(CH2)p-morpholinyl; —(CH2)p-pyrrolidinyl; —(CH2)p-tetrahydroisoquinoline; —(CH2)p-heteroaryl; heteroarylcarbonyl; phenylcarbonyl; (C1-C6)alkylcarbonyl; —(CH2)p—COOR?; or phenylsulphonyl group; and when X represents a carbon atom R3 represents a hydrogen atom; a group —NR5R6; —NHCOR7; —CONHR5; —COR7; —NHCONH2; —OH or —CH2OH, R4 represents in particular a hydrogen atom; an optionally substituted group —(CH2)p-phenyl; a group —(CH2)p-heteroaryl; or a group —(CH2)tNR7R8. Preparation process and therapeutic application.Type: GrantFiled: November 21, 2001Date of Patent: December 27, 2005Assignee: Sanofi-SynthelaboInventors: Francis Barth, Daniel Bichon, Frank Bolkenius, Viviane Van Dorsselaer
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Publication number: 20050182104Abstract: This invention discloses and claims a compound conforming to the general formula (I): Wherein R1, R2, R?2, R3, R4 and R5 are as described herein. The compounds of the present invention exhibit an inhibitory effect on the production of ?-amyloid peptide (?-A4) by inhibition of gamma protease. Therefore, the compounds of the present invention are useful in the treatment of pathologies such as senile dementia, Alzheimer's disease, Down's syndrome, Parkinson's disease, amyloid angiopathy and/or cerebrovascular disorders.Type: ApplicationFiled: January 14, 2005Publication date: August 18, 2005Applicant: Sanofi-SynthelaboInventors: Sylvie Balter, Bruno Schoentjes, Viviane Van Dorsselaer
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Publication number: 20050032779Abstract: The invention relates to benzimidazole derivatives of general formula in which X represents a nitrogen atom or a carbon atom; and when X represents a nitrogen atom: R3 represents a hydrogen atom or a C1-C4 alkyl group, or does not exist, to give the compounds of formula (I) comprising a secondary or tertiary amine; R4 represents a hydrogen atom or a C1-C6 alkyl, C3-C7 cycloalkyl, optionally substituted C3-C7 heterocycloalkyl, —(CH2)p-heteroaryl, heteroaryl-carbonyl, phenylcarbonyl, (C1-C6)alkylcarbonyl, —(CH2)pCOOR, optionally substituted phenylsulphonyl or optionally substituted —(CH2)p-phenyl group, and, when X represents a carbon atom: R3 represents a hydrogen atom or a group —NR5R6, —N(R5)3+, —NHCOR7, —CONHR5, —COR7, —NHCONH2, —OH or —CH2OH, R4 represents a hydrogen atom or an optionally substituted —(CH2)p-phenyl, —(CH2)p-heteroaryl or —(CH2)tNR7R8 group. Preparation process and therapeutic application.Type: ApplicationFiled: September 13, 2004Publication date: February 10, 2005Inventors: Francis Barth, Daniel Bichon, Frank Bolkenius, Viviane Van Dorsselaer
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Patent number: 6794382Abstract: The invention relates to benzimidazole derivatives of general formula in which X represents a nitrogen atom or a carbon atom; and when X represents a nitrogen atom: R3 represents a hydrogen atom or a C1-C4 alkyl group, or does not exist, to give the compounds of formula (I) comprising a secondary or tertiary amine; R4 represents a hydrogen atom or a C1-C6 alkyl, C3-C7 cycloalkyl, optionally substituted C3-C7 heterocycloalkyl, —(CH2)p-heteroaryl, heteroaryl-carbonyl, phenylcarbonyl, (C1-C6)alkylcarbonyl, —(CH2)pCOOR, optionally substituted phenylsulphonyl or optionally substituted —(CH2)p-phenyl group, and, when X represents a carbon atom: R3 represents a hydrogen atom or a group —NR5R6, —N(R5)3+, —NHCOR7, —CONHR5, —COR7, —NHCONH2, —OH or —CH2OH, R4 represents a hydrogen atom or an optionally substituted —(CH2)p-phenyl, —(CH2)p-heteroaryl or —(CH2)tNR7R8 group.Type: GrantFiled: January 30, 2003Date of Patent: September 21, 2004Assignee: Sanofi-SynthelaboInventors: Francis Barth, Daniel Bichon, Frank Bolkenius, Viviane Van Dorsselaer
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Publication number: 20040029866Abstract: The invention relates to benzimidazole derivatives of general formula (I) 1Type: ApplicationFiled: May 23, 2003Publication date: February 12, 2004Inventors: Francis Barth, Daniel Bichon, Frank Bolkenius, Viviane Van Dorsselaer