Patents by Inventor Vladimir Kaigorodov

Vladimir Kaigorodov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein glycosylation modification in methylotrophic yeast
    Patent number: 8883445
    Abstract: The present invention provides genetically engineered strains of methylotrophic yeast including Pichia and especially Pichia pastoris capable of producing proteins with reduced or modified glycosylation. Methods of producing glycoproteins with reduced and/or modified glycosylation using such genetically engineered strains of Pichia are also provided. Vectors, which comprise coding sequences for ?-1,2-mannosidase I, glucosidase II, GlcNAc-tranferase I and mannosidase II or comprising OCH1 disrupting sequence, for transforming methylotrophic yeasts are contemplated by the present invention. Kit for providing the comtemplated vectors are also included in this invention.
    Type: Grant
    Filed: July 13, 2007
    Date of Patent: November 11, 2014
    Assignees: Research Corporation Technologies, Inc., Universiteit Gent, Vib, VZW
    Inventors: Roland Contreras, Nico L. M. Callewaert, Steven C. J. Geysens, Vladimir Kaigorodov, Vervecken Wouter
  • Modification of protein glycosylation in methylotrophic yeast
    Patent number: 8058053
    Abstract: The present invention relates to methods and genetically engineered methylotrophic yeast strains for producing glycoproteins with mammalian-like glycosylation. The present invention also relates to vectors useful for generating methylotrophic yeast strains capable of producing glycoproteins with mammalian-like glycosylation. Glycoproteins produced from the genetically engineered methylotrophic yeast strains are also provided.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: November 15, 2011
    Assignees: VIB, VZW, Universiteit Gent, Research Corporation Technologies, Inc.
    Inventors: Roland Contreras, Nico L. M. Callewaert, Wouter Vervecken, Vladimir Kaigorodov
  • MODIFICATION OF PROTEIN GLYCOSYLATION IN METHYLOTROPHIC YEAST
    Publication number: 20090263863
    Abstract: The present invention relates to methods and genetically engineered methylotrophic yeast strains for producing glycoproteins with mammalian-like glycosylation. The present invention also relates to vectors useful for generating methylotrophic yeast strains capable of producing glycoproteins with mammalian-like glycosylation. Glycoproteins produced from the genetically engineered methylotrophic yeast strains are also provided.
    Type: Application
    Filed: February 11, 2009
    Publication date: October 22, 2009
    Applicants: VIB, VZW, UNIVERSITEIT GENT, RESEARCH CORPORATION TECHNOLOGIES, INC.
    Inventors: Roland Contreras, Nico L. M. Callewaert, Wouter Vervecken, Vladimir Kaigorodov
  • Modification of protein glycosylation in methylotrophic yeast
    Patent number: 7507573
    Abstract: The present invention relates to methods and genetically engineered methylotrophic yeast strains for producing glycoproteins with mammalian-like glycosylation. The present invention also relates to vectors useful for generating methylotrophic yeast strains capable of producing glycoproteins with mammalian-like glycosylation. Glycoproteins produced from the genetically engineered methylotrophic yeast strains are also provided.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: March 24, 2009
    Assignees: VIB, vzw, Universiteit Gent, Research Corporation Technologies, Inc.
    Inventors: Roland Contreras, Nico L. M. Callewaert, Wouter Vervecken, Vladimir Kaigorodov
  • Protein glycosylation modification in methylotrophic yeast
    Publication number: 20080009037
    Abstract: The present invention provides genetically engineered strains of methylotrophic yeast including Pichia and especially Pichia pastoris capable of producing proteins with reduced or modified glycosylation. Methods of producing glycoproteins with reduced and/or modified glycosylation using such genetically engineered strains of Pichia are also provided. Vectors, which comprise coding sequences for ?-1,2-mannosidase I, glucosidase II, GlcNAc-tranferase I and mannosidase II or comprising OCH1 disrupting sequence, for transforming methylotrophic yeasts are contemplated by the present invention. Kit for providing the comtemplated vectors are also included in this invention.
    Type: Application
    Filed: July 13, 2007
    Publication date: January 10, 2008
    Applicant: Flanders Interuniversity Institute For Biotechnology
    Inventors: Roland Contreras, Nico Callewaert, Steven Geysens, Vladimir Kaigorodov, Vervecken Wouter
  • Protein glycosylation modification in methylotrophic yeast
    Patent number: 7252933
    Abstract: The present invention provides genetically engineered strains of methylotrophic yeast including Pichia and especially Pichia pastoris capable of producing proteins with reduced or modified glycosylation. Methods of producing glycoproteins with reduced and/or modified glycosylation using such genetically engineered strains of Pichia are also provided. Vectors, which comprise coding sequences for ?-1,2-mannosidase I, glucosidase II, GlcNAc-tranferase I and mannosidase II or comprising OCH1 disrupting sequence, for transforming methylotrophic yeasts are contemplated by the present invention. Kit for providing the comtemplated vectors are also included in this invention.
    Type: Grant
    Filed: June 26, 2002
    Date of Patent: August 7, 2007
    Assignee: Flanders Interuniversity Institute for Biotechnology
    Inventors: Roland Contreras, Nico L. M. Callewaert, Steven C. J. Geysens, Vladimir Kaigorodov, Vervecken Wouter
  • Modification of protein glycosylation in methylotrophic yeast
    Publication number: 20050106664
    Abstract: The present invention relates to methods and genetically engineered methylotrophic yeast strains for producing glycoproteins with mammalian-like glycosylation. The present invention also relates to vectors useful for generating methylotrophic yeast strains capable of producing glycoproteins with mammalian-like glycosylation. Glycoproteins produced from the genetically engineered methylotrophic yeast strains are also provided.
    Type: Application
    Filed: November 14, 2003
    Publication date: May 19, 2005
    Inventors: Roland Contreras, Nico Callewaert, Wouter Vervecken, Vladimir Kaigorodov
  • PROTEIN GLYCOSYLATION MODIFICATION IN METHYLOTROPHIC YEAST
    Publication number: 20040018588
    Abstract: The present invention provides genetically engineered strains of methylotrophic yeast including Pichia and especially Pichia pastoris capable of producing proteins with reduced or modified glycosylation. Methods of producing glycoproteins with reduced and/or modified glycosylation using such genetically engineered strains of Pichia are also provided. Vectors, which comprise coding sequences for &agr;-1,2-mannosidase I, glucosidase II, GlcNAc-tranferase I and mannosidase II or comprising OCH1 disrupting sequence, for transforming methylotrophic yeasts are contemplated by the present invention. Kit for providing the comtemplated vectors are also included in this invention.
    Type: Application
    Filed: June 26, 2002
    Publication date: January 29, 2004
    Inventors: Roland Contreras, Nico L.M. Callewaert, Steven C. J. Geysens, Vladimir Kaigorodov, Vervecken Wouter