Patents by Inventor Vu Bui
Vu Bui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11779911Abstract: In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and b) converting the metathesis product to the fatty olefin derivative. Each R1 is independently selected from H, C1-18 alkyl, and C2-18 alkenyl; R2b is C1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.Type: GrantFiled: July 30, 2021Date of Patent: October 10, 2023Assignee: PROVIVI, INC.Inventors: Keith M. Wampler, Peter Meinhold, Pedro Coelho, Vu Bui, Hasan Mehdi
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Publication number: 20220136018Abstract: The present application relates to methods of producing one or more fatty alcohols and/or one or more fatty aldehydes from one or more unsaturated lipid moieties by combining the obtainment or production of the one or more unsaturated lipid moieties from a biological source with conversion by non-biological means of the one or more unsaturated lipid moieties to one or more fatty alcohols and/or one or more fatty aldehydes. The present application also relates to recombinant microorganisms having a biosynthesis pathway for the production of one or more unsaturated lipid moieties. The one or more fatty alcohols can further be chemically converted to one or more corresponding fatty acetates. The one or more fatty alcohols, one or more fatty aldehydes and/or one or more fatty acetates produced by the methods described herein may be one or more insect pheromones, one or more fragrances, one or more flavoring agents, or one or more polymer intermediates.Type: ApplicationFiled: November 15, 2021Publication date: May 5, 2022Inventors: Konrad B. OTTE, Micah SHEPPARD, Vu BUI, Keith M. WAMPLER, Effendi LEONARD
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Publication number: 20220032280Abstract: In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and b) converting the metathesis product to the fatty olefin derivative. Each R1 is independently selected from H, C1-18 alkyl, and C2-18 alkenyl; R2b is C1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.Type: ApplicationFiled: July 30, 2021Publication date: February 3, 2022Applicants: Provivi, Inc., XiMo AGInventors: Keith M. Wampler, Peter Meinhold, Pedro Coelho, Vu Bui, Hasan Mehdi
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Patent number: 11214818Abstract: The present application relates to methods of producing one or more fatty alcohols and/or one or more fatty aldehydes from one or more unsaturated lipid moieties by combining the obtainment or production of the one or more unsaturated lipid moieties from a biological source with conversion by non-biological means of the one or more unsaturated lipid moieties to one or more fatty alcohols and/or one or more fatty aldehydes. The present application also relates to recombinant microorganisms having a biosynthesis pathway for the production of one or more unsaturated lipid moieties. The one or more fatty alcohols can further be chemically converted to one or more corresponding fatty acetates. The one or more fatty alcohols, one or more fatty aldehydes and/or one or more fatty acetates produced by the methods described herein may be one or more insect pheromones, one or more fragrances, one or more flavoring agents, or one or more polymer intermediates.Type: GrantFiled: June 6, 2017Date of Patent: January 4, 2022Assignee: Provivi, Inc.Inventors: Konrad B. Otte, Micah Sheppard, Vu Bui, Keith M. Wampler, Effendi Leonard
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Patent number: 11155505Abstract: Methods for preparation of olefins, including 8- and 11-unsaturated monoenes and polyenes, via transition metathesis-based synthetic routes are described. Metathesis reactions in the methods are catalyzed by transition metal catalysts including tungsten-, molybdenum-, and ruthenium-based catalysts. The olefins include insect pheromones useful in a number of agricultural applications.Type: GrantFiled: August 16, 2019Date of Patent: October 26, 2021Assignee: PROVIVI, INC.Inventors: Keith M. Wampler, Vu Bui, David Rozzell, Pedro Coelho, Arthur Floruti, Levente Ondi, Hasan Mehdi, Gabor Eros
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Patent number: 11077433Abstract: In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and b) converting the metathesis product to the fatty olefin derivative. Each R1 is independently selected from H, C1-18 alkyl, and C2-18 alkenyl; R2b is C1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.Type: GrantFiled: February 24, 2020Date of Patent: August 3, 2021Assignee: PROVIVI, INC.Inventors: Keith M. Wampler, Peter Meinhold, Pedro Coelho, Vu Bui, Levente Ondi, Hasan Mehdi
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Patent number: 10796259Abstract: A computing system includes a connection detection system that identifies a set of connected deliverables among a plurality of different deliverables in a data store and timeline generator logic that generates a representation of a timeline having nodes connected by edges, each node representing a deliverable and each edge connecting a pair of nodes corresponding to a connection between the deliverables represented by the pair of nodes connected by the edge. The computing system also includes a user interaction system that controls interaction with the plurality of different deliverables, the user interaction system comprising link setting logic that generates a link setting user interface mechanism that is actuatable to modify one or more connections and surfacing logic that controls a display to display the representation of the timeline and the link setting user interface mechanism.Type: GrantFiled: September 7, 2018Date of Patent: October 6, 2020Assignee: Microsoft Technology Licensing, LLCInventors: Joseph Sullivan, Jill Campbell, Ngoc Vu Bui, Nir Michaely, Chenying Yang
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Publication number: 20200261898Abstract: In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and b) converting the metathesis product to the fatty olefin derivative. Each R1 is independently selected from H, C1-18 alkyl, and C2-18 alkenyl; R2b is C1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.Type: ApplicationFiled: February 24, 2020Publication date: August 20, 2020Applicant: Provivi, Inc.Inventors: Keith M. Wampler, Peter Meinhold, Pedro Coelho, Vu Bui, Levente Ondi, Hasan Mehdi
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Patent number: 10596562Abstract: In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and b) converting the metathesis product to the fatty olefin derivative. Each R1 is independently selected from H, C1-18 alkyl, and C2-18 alkenyl; R2b is C1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.Type: GrantFiled: September 29, 2017Date of Patent: March 24, 2020Assignee: PROVIVI, INC.Inventors: Keith M. Wampler, Peter Meinhold, Pedro Coelho, Vu Bui, Levente Ondi, Hasan Mehdi
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Publication number: 20200039900Abstract: Methods for preparation of olefins, including 8- and 11-unsaturated monoenes and polyenes, via transition metathesis-based synthetic routes are described. Metathesis reactions in the methods are catalyzed by transition metal catalysts including tungsten-, molybdenum-, and ruthenium-based catalysts. The olefins include insect pheromones useful in a number of agricultural applications.Type: ApplicationFiled: August 16, 2019Publication date: February 6, 2020Applicant: Provivi, Inc.Inventors: Keith M. Wampler, Vu Bui, David Rozzell, Pedro Coelho, Arthur Floruti, Levente Ondi, Hasan Mehdi, Gabor Eros
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Publication number: 20190347094Abstract: A computing system includes a connection detection system that identifies a set of connected deliverables among a plurality of different deliverables in a data store and timeline generator logic that generates a representation of a timeline having nodes connected by edges, each node representing a deliverable and each edge connecting a pair of nodes corresponding to a connection between the deliverables represented by the pair of nodes connected by the edge. The computing system also includes a user interaction system that controls interaction with the plurality of different deliverables, the user interaction system comprising link setting logic that generates a link setting user interface mechanism that is actuatable to modify one or more connections and surfacing logic that controls a display to display the representation of the timeline and the link setting user interface mechanism.Type: ApplicationFiled: September 7, 2018Publication date: November 14, 2019Inventors: Joseph SULLIVAN, Jill Campbell, Ngoc Vu Bui, Nir Michaely, Chenying Yang
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Publication number: 20190347589Abstract: A computing system includes a connection detection system that identifies a set of connected deliverables among a plurality of different deliverables in a data store and graph generator logic that generates a representation of a graph having nodes connected by edges, each node representing a deliverable and each edge connecting a pair of nodes corresponding to a connection between the deliverables represented by the pair of nodes connected by the edge. The computing system also includes a user interaction system that controls interaction with the plurality of different deliverables, the user interaction system comprises link setting logic that generates a link setting user interface mechanism that is actuatable to modify one or more connections and surfacing logic that controls a display to display the representation of the graph and the link setting user interface mechanism.Type: ApplicationFiled: September 7, 2018Publication date: November 14, 2019Inventors: Joseph SULLIVAN, Jill CAMPBELL, Ngoc Vu BUI, Nir MICHAELY, Chenying YANG
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Publication number: 20190136272Abstract: The present application relates to methods of producing one or more fatty alcohols and/or one or more fatty aldehydes from one or more unsaturated lipid moieties by combining the obtainment or production of the one or more unsaturated lipid moieties from a biological source with conversion by non-biological means of the one or more unsaturated lipid moieties to one or more fatty alcohols and/or one or more fatty aldehydes. The present application also relates to recombinant microorganisms having a biosynthesis pathway for the production of one or more unsaturated lipid moieties. The one or more fatty alcohols can further be chemically converted to one or more corresponding fatty acetates. The one or more fatty alcohols, one or more fatty aldehydes and/or one or more fatty acetates produced by the methods described herein may be one or more insect pheromones, one or more fragrances, one or more flavoring agents, or one or more polymer intermediates.Type: ApplicationFiled: June 6, 2017Publication date: May 9, 2019Inventors: Konrad B. OTTE, Micah SHEPPARD, Vu BUI, Keith M. WAMPLER, Effendi LEONARD
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Patent number: 10202620Abstract: In certain aspects, the present invention provides methods for producing terminally hydroxylated alkenes and alkynes by contacting an unsaturated or saturated hydrocarbon substrate with a hydroxylase enzyme. Exemplary terminal hydroxylases useful for carrying out the methods of the invention exhibit strong selectivity towards one terminal carbon of a hydrocarbon substrate and include, but are not limited to, non-heme diiron alkane monooxygenases, cytochromes P450 (e.g., cytochromes P450 of the CYP52 and CYP153 family), as well as long chain alkane hydroxylases. In some embodiments, the terminally hydroxylated alkene or alkyne is further converted to a terminal alkenal. In certain embodiments, terminally hydroxylated alkenes and alkynes are useful as insect pheromones which modify insect behavior. In other embodiments, terminally hydroxylated alkenes and alkynes are useful intermediates for producing pheromones via acetylation or oxidation of the alcohol moiety.Type: GrantFiled: September 3, 2015Date of Patent: February 12, 2019Assignee: PROVIVI, INC.Inventors: Pedro Coelho, Mike M. Y. Chen, Peter Meinhold, Catherine Mee-Hie Cho, Vu Bui, Thomas Heel
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Patent number: 9981898Abstract: The present invention relates, in part, to an improved process for oxidation of alcohols containing oxidatively sensitive functional groups, using inexpensive reagents under mild reaction conditions to provide high yields of carbonyl products such as aldehydes or ketones. In certain embodiments, an aldehyde product is obtained by contacting an oxidatively sensitive alcohol, such as an alkenol, with an oxidant and a TEMPO catalyst under conditions sufficient to convert the alkenol to the aldehyde.Type: GrantFiled: March 10, 2017Date of Patent: May 29, 2018Assignee: PROVIVI, INC.Inventors: Vu Bui, Peter Meinhold, Pedro Coelho, Keith M. Wampler, Michael Cockrem
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Publication number: 20180099268Abstract: In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and b) converting the metathesis product to the fatty olefin derivative. Each R1 is independently selected from H, C1-18 alkyl, and C2-18 alkenyl; R2b is C1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.Type: ApplicationFiled: September 29, 2017Publication date: April 12, 2018Applicant: Provivi, Inc.Inventors: Keith M. Wampler, Peter Meinhold, Pedro Coelho, Vu Bui, Levente Ondi, Hasan Mehdi
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Patent number: 9776179Abstract: In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and b) converting the metathesis product to the fatty olefin derivative. Each R1 is independently selected from H, C1-18 alkyl, and C2-18 alkenyl; R2b is C1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.Type: GrantFiled: November 17, 2016Date of Patent: October 3, 2017Assignee: PROVIVI, INC.Inventors: Keith M Wampler, Peter Meinhold, Pedro Coelho, Vu Bui, Levente Ondi, Hasan Mehdi
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Publication number: 20170137365Abstract: In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and b) converting the metathesis product to the fatty olefin derivative. Each R1 is independently selected from H, C1-18 alkyl, and C2-18 alkenyl; R2b is C1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.Type: ApplicationFiled: November 17, 2016Publication date: May 18, 2017Applicant: PROVIVI, INC.Inventors: KEITH M. WAMPLER, PETER MEINHOLD, PEDRO COELHO, VU BUI, LEVENTE ONDI, HASAN MEHDI
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Publication number: 20160108436Abstract: In certain aspects, the present invention provides methods for producing terminally hydroxylated alkenes and alkynes by contacting an unsaturated or saturated hydrocarbon substrate with a hydroxylase enzyme. Exemplary terminal hydroxylases useful for carrying out the methods of the invention exhibit strong selectivity towards one terminal carbon of a hydrocarbon substrate and include, but are not limited to, non-heme diiron alkane monooxygenases, cytochromes P450 (e.g., cytochromes P450 of the CYP52 and CYP153 family), as well as long chain alkane hydroxylases. In some embodiments, the terminally hydroxylated alkene or alkyne is further converted to a terminal alkenal. In certain embodiments, terminally hydroxylated alkenes and alkynes are useful as insect pheromones which modify insect behavior. In other embodiments, terminally hydroxylated alkenes and alkynes are useful intermediates for producing pheromones via acetylation or oxidation of the alcohol moiety.Type: ApplicationFiled: September 3, 2015Publication date: April 21, 2016Applicant: Provivi, Inc.Inventors: PEDRO COELHO, Mike M.Y. Chen, Peter Meinhold, Catherine Mee-Hie Cho, Vu Bui, Thomas Heel
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Patent number: 9073867Abstract: Provided herein are processes for preparing caprolactam from a starting material such as one or more of the cis,cis-, cis,trans- and trans,trans-double-bond isomers of muconamide, muconic acid ester, or muconic acid. The starting material, intermediates, and caprolactam prepared therefrom can contain carbon atoms derived from biomass containing detectable 14C content determined according to ASTM D6866 and optionally containing a 14C content up to 0.0000000001% (one part per trillion). Caprolactam so prepared can be used to make various polyamides.Type: GrantFiled: April 9, 2012Date of Patent: July 7, 2015Assignee: Amyris, Inc.Inventors: Laetitia Coudray, Vu Bui, John W. Frost, Dirk Schweitzer