Patents by Inventor W. Scott McDougal
W. Scott McDougal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180188252Abstract: The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples. The invention is also directed to markers for therapeutic efficacy.Type: ApplicationFiled: August 11, 2017Publication date: July 5, 2018Inventors: BRUCE R. ZETTER, Adam S. Feldman, W. Scott McDougal
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Patent number: 9968369Abstract: One aspect of the present invention relates to a method of using peristalsis to force a polymer plug through a mammalian lumen, thereby removing any calculi and/or calculi fragments present in the lumen. In one embodiment, the method is used as an alternative to conventional lithotripsy. In another embodiment, the method is used in conjunction with lithotripsy, thereby removing the small calculi fragments that result from such procedures.Type: GrantFiled: September 29, 2015Date of Patent: May 15, 2018Assignee: Genzyme CorporationInventors: W. Scott McDougal, Dianne E. Sacco, Alexander Schwarz, Jean-Marie Vogel
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Publication number: 20180120319Abstract: The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples. The invention is also directed to markers for therapeutic efficacy.Type: ApplicationFiled: June 5, 2017Publication date: May 3, 2018Inventors: Bruce R. Zetter, Adam S. Feldman, W. Scott McDougal
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Publication number: 20170281203Abstract: One aspect of the present invention relates to a method of using peristalsis to force a polymer plug through a mammalian lumen, thereby removing any calculi and/or calculi fragments present in the lumen. In one embodiment, the method is used as an alternative to conventional lithotripsy. In another embodiment, the method is used in conjunction with lithotripsy, thereby removing the small calculi fragments that result from such procedures.Type: ApplicationFiled: September 29, 2015Publication date: October 5, 2017Inventors: W. Scott McDougal, Dianne E. Sacco, Alexander Schwarz, Jean-Marie Vogel
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Publication number: 20170086849Abstract: The present invention improves significantly the success rate of lithotripsy and reduces the risk of tissue damage, by injecting a temporary plug in front, and optionally behind a concretion (for extracorporeal lithotripsy) or behind a concretion (for intracorporeal lithotripsy). One aspect of the present invention relates to injecting an inverse thermosensitive polymer solution into a lumen, thereby preventing the migration of a concretion, or its fragments, upon extracorporeal or intracorporeal lithotripsy.Type: ApplicationFiled: May 9, 2016Publication date: March 30, 2017Inventors: Alexander Schwarz, W. Scott McDougal
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Publication number: 20170023574Abstract: The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples. The invention is also directed to markers for therapeutic efficacy.Type: ApplicationFiled: February 19, 2016Publication date: January 26, 2017Inventors: Bruce R. Zetter, Adam S. Feldman, W. Scott McDougal
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Publication number: 20160249941Abstract: One aspect of the present invention relates to a method of using peristalsis to force a polymer plug through a mammalian lumen, thereby removing any calculi and/or calculi fragments present in the lumen. In one embodiment, the method is used as an alternative to conventional lithotripsy. In another embodiment, the method is used in conjunction with lithotripsy, thereby removing the small calculi fragments that result from such procedures.Type: ApplicationFiled: September 29, 2015Publication date: September 1, 2016Inventors: W. Scott McDougal, Dianne E. Sacco, Alexander Schwarz, Jean-Marie Vogel
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Publication number: 20160015393Abstract: The present invention improves significantly the success rate of lithotripsy and reduces the risk of tissue damage, by injecting a temporary plug in front, and optionally behind a concretion (for extracorporeal lithotripsy) or behind a concretion (for intracorporeal lithotripsy). One aspect of the present invention relates to injecting an inverse thermosensitive polymer solution into a lumen, thereby preventing the migration of a concretion, or its fragments, upon extracorporeal or intracorporeal lithotripsy.Type: ApplicationFiled: February 25, 2015Publication date: January 21, 2016Inventors: Alexander Schwarz, W. Scott McDougal
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Patent number: 9161767Abstract: One aspect of the present invention relates to a method of using peristalsis to force a polymer plug through a mammalian lumen, thereby removing any calculi and/or calculi fragments present in the lumen. In one embodiment, the method is used as an alternative to conventional lithotripsy. In another embodiment, the method is used in conjunction with lithotripsy, thereby removing the small calculi fragments that result from such procedures.Type: GrantFiled: April 22, 2014Date of Patent: October 20, 2015Assignee: GENZYME CORPORATIONInventors: W. Scott McDougal, Dianne E. Sacco, Alexander Schwarz, Jean-Marie Vogel
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Patent number: 8998928Abstract: The present invention improves significantly the success rate of lithotripsy and reduces the risk of tissue damage, by injecting a temporary plug in front, and optionally behind a concretion (for extracorporeal lithotripsy) or behind a concretion (for intracorporeal lithotripsy). One aspect of the present invention relates to injecting an inverse thermosensitive polymer solution into a lumen, thereby preventing the migration of a concretion, or its fragments, upon extracorporeal or intracorporeal lithotripsy.Type: GrantFiled: February 27, 2013Date of Patent: April 7, 2015Assignee: Genzyme CorporationInventors: Alexander Schwarz, W. Scott McDougal
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Publication number: 20140288569Abstract: One aspect of the present invention relates to a method of using peristalsis to force a polymer plug through a mammalian lumen, thereby removing any calculi and/or calculi fragments present in the lumen. In one embodiment, the method is used as an alternative to conventional lithotripsy. In another embodiment, the method is used in conjunction with lithotripsy, thereby removing the small calculi fragments that result from such procedures.Type: ApplicationFiled: April 22, 2014Publication date: September 25, 2014Applicants: Genzyme Corporation, The General Hospital CorporationInventors: W. Scott McDougal, Dianne E. Sacco, Alexander Schwarz, Jean-Marie Vogel
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Patent number: 8685659Abstract: The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples. The invention is also directed to markers for therapeutic efficacy.Type: GrantFiled: January 30, 2006Date of Patent: April 1, 2014Assignees: Children's Medical Center Corporation, The General Hospital CorporationInventors: Bruce R. Zetter, Adam S. Feldman, W. Scott McDougal
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Patent number: 8409218Abstract: The present invention improves significantly the success rate of lithotripsy and reduces the risk of tissue damage, by injecting a temporary plug in front, and optionally behind a concretion (for extracorporeal lithotripsy) or behind a concretion (for intracorporeal lithotripsy). One aspect of the present invention relates to injecting an inverse thermosensitive polymer solution into a lumen, thereby preventing the migration of a concretion, or its fragments, upon extracorporeal or intracorporeal lithotripsy.Type: GrantFiled: November 15, 2010Date of Patent: April 2, 2013Assignee: Genzyme CorporationInventors: Alexander Schwarz, W. Scott McDougal
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Patent number: 8361455Abstract: One aspect of the present invention relates to a method of using peristalsis to force a polymer plug through a mammalian lumen, thereby removing any calculi and/or calculi fragments present in the lumen. In one embodiment, the method is used as an alternative to conventional lithotripsy. In another embodiment, the method is used in conjunction with lithotripsy, thereby removing the small calculi fragments that result from such procedures.Type: GrantFiled: April 27, 2006Date of Patent: January 29, 2013Assignees: Pluromed, Inc., The General Hospital CorporationInventors: W. Scott McDougal, Dianne E. Sacco, Alexander Schwarz, Jean-Marie Vogel
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Publication number: 20110060256Abstract: The present invention improves significantly the success rate of lithotripsy and reduces the risk of tissue damage, by injecting a temporary plug in front, and optionally behind a concretion (for extracorporeal lithotripsy) or behind a concretion (for intracorporeal lithotripsy).Type: ApplicationFiled: November 15, 2010Publication date: March 10, 2011Applicant: Pluromed, Inc.Inventors: Alexander Schwarz, W. Scott McDougal
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Publication number: 20090239245Abstract: The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples. The invention is also directed to markers for therapeutic efficacy.Type: ApplicationFiled: January 30, 2006Publication date: September 24, 2009Inventors: Bruce R. Zetter, Adam S. Feldman, W. Scott McDougal
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Patent number: 6206900Abstract: A clot evacuation catheter includes a hollow tubular body disposed within an outer lumen. The tubular body is elongate and includes a selectively rotatable cutting blade disposed within a distal portion thereof to cut clots occluded in at least one opening of the cutting blade. The tubular body also includes a fluid conveying irrigation lumen to deliver fluid to a distal end of the catheter at predetermined times. In an alternative embodiment of the present invention, a hood member extends from the distal portion of the tubular body. The hood member has a distal end that is spaced from, but coaxial with, the distal portion of the tubular body through a side portion of the hood member.Type: GrantFiled: June 11, 1999Date of Patent: March 27, 2001Assignee: The General Hospital CorporationInventors: Shahin Tabatabaei, W. Scott McDougal