Patents by Inventor Wael I. Yared
Wael I. Yared has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210172942Abstract: Presented herein are methods, systems, and apparatus for single analyte detection or multiplexed analyte detection based on amplified luminescent proximity homogeneous assay (“alpha”) technology, but using hollow polymer fiber optics doped with ‘acceptor bead’ dye (e.g., thioxene, anthracene, rubrene, and/or lanthanide chelates) or ‘donor bead’ dye (e.g., phthalocyanine) that carry a signal generated by the dopant via singlet oxygen channeling.Type: ApplicationFiled: February 2, 2021Publication date: June 10, 2021Inventors: Roger Bossé, Wael I. Yared, Peter A. Harvey, Kevin Groves, Ilias Faqir, Michael Meltzer
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Patent number: 10942177Abstract: Presented herein are methods, systems, and apparatus for single analyte detection or multiplexed analyte detection based on amplified luminescent proximity homogeneous assay (“alpha”) technology, but using hollow polymer fiber optics doped with ‘acceptor bead’ dye (e.g., thioxene, anthracene, rubrene, and/or lanthanide chelates) or ‘donor bead’ dye (e.g., phthalocyanine) that carry a signal generated by the dopant via singlet oxygen channeling.Type: GrantFiled: February 25, 2020Date of Patent: March 9, 2021Assignee: PerkinElmer Health Sciences, Inc.Inventors: Roger Bossé, Wael I. Yared, Peter A. Harvey, Kevin Groves, Ilias Faqir, Michael Meltzer
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Publication number: 20200232926Abstract: Presented herein are methods, systems, and apparatus for single analyte detection or multiplexed analyte detection based on amplified luminescent proximity homogeneous assay (“alpha”) technology, but using hollow polymer fiber optics doped with ‘acceptor bead’ dye (e.g., thioxene, anthracene, rubrene, and/or lanthanide chelates) or ‘donor bead’ dye (e.g., phthalocyanine) that carry a signal generated by the dopant via singlet oxygen channeling.Type: ApplicationFiled: February 25, 2020Publication date: July 23, 2020Inventors: Roger Bossé, Wael I. Yared, Peter A. Harvey, Kevin Groves, Ilias Faqir, Michael Meltzer
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Patent number: 10677735Abstract: Presented herein are methods, systems, and apparatus for single analyte detection or multiplexed analyte detection based on amplified luminescent proximity homogeneous assay (“alpha”) technology, but using hollow polymer fiber optics doped with ‘acceptor bead’ dye (e.g., thioxene, anthracene, rubrene, and/or lanthanide chelates) or ‘donor bead’ dye (e.g., phthalocyanine) that carry a signal generated by the dopant via singlet oxygen channeling.Type: GrantFiled: November 22, 2016Date of Patent: June 9, 2020Assignee: PerkinElmer Health Sciences, Inc.Inventors: Roger Bossé, Wael I. Yared, Peter A. Harvey, Kevin Groves, Ilias Faqir, Michael Meltzer
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Patent number: 10064584Abstract: The invention relates to a combined x-ray and optical (light-based) tomographic imaging system that provides functional information at greater resolution than can be achieved by optical tomography alone. The system is configured with one or more x-ray sources, x-ray detectors, light sources, and light detectors arranged on a gantry which rotates about an imaging chamber containing the object to be imaged. The system thereby allows both x-ray radiation and light to be directed into the object at multiple locations. Processing methods of the invention go beyond simple co-registration of images obtained from two or more imaging techniques. Both x-ray data and light data are used together in optical tomographic reconstruction to create the tomographic image, thereby allowing a more accurate and/or higher resolution final image.Type: GrantFiled: December 21, 2006Date of Patent: September 4, 2018Assignee: VisEn Medical, Inc.Inventor: Wael I. Yared
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Patent number: 9901254Abstract: The invention relates to systems and methods for tomographic imaging of a subject comprising diffuse media by converting measurements of electromagnetic radiation, e.g., fluorescent light, obtained in free space exterior to the subject into data that would be measured if the subject were surrounded by an infinite and homogeneous diffusive medium, e.g., a medium with optical properties equal to the average optical properties of the subject. After applying a transformation to convert measurements to virtually-matched values, propagation of light is simulated from the index-matched surface to a set of virtual detectors exterior to the subject and arranged in a geometrically advantageous fashion, for example, in a planar array, thereby facilitating the use of fast reconstruction techniques.Type: GrantFiled: March 13, 2013Date of Patent: February 27, 2018Assignee: VisEn Medical, Inc.Inventors: Jorge Ripoll Lorenzo, Wael I. Yared, Joshua Kempner
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Publication number: 20170167984Abstract: Presented herein are methods, systems, and apparatus for single analyte detection or multiplexed analyte detection based on amplified luminescent proximity homogeneous assay (“alpha”) technology, but using hollow polymer fiber optics doped with ‘acceptor bead’ dye (e.g., thioxene, anthracene, rubrene, and/or lanthanide chelates) or ‘donor bead’ dye (e.g., phthalocyanine) that carry a signal generated by the dopant via singlet oxygen channeling.Type: ApplicationFiled: November 22, 2016Publication date: June 15, 2017Inventors: Roger Bossé, Wael I. Yared, Peter A. Harvey, Kevin Groves, Ilias Faqir, Michael Meltzer
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Patent number: 9311722Abstract: In certain embodiments, the invention relates to systems and methods for altering an image to compensate for variation in one or more physical and/or supervenient properties (e.g., optical absorption and/or scattering) in heterogeneous, diffuse tissue, thereby attenuating the effects of tissue waveguiding. The methods enable the proper identification of emission image regions that evidence waveguiding of electromagnetic radiation, and enables compensation of emission images for such waveguiding. The methods preserve the depth localization accuracy of the FMT approach and improve optical reconstruction in the targeted areas while eliminating spurious components of fluorescence from the acquired data set. Calibration methods for probe concentration mapping are also presented.Type: GrantFiled: February 14, 2014Date of Patent: April 12, 2016Assignee: VisEn Medical, Inc.Inventors: Wael I. Yared, Pouyan Mohajerani, Joshua Kempner
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Patent number: 8918163Abstract: The invention facilitates transport of an immobilized, anesthetized small animal across multiple single-modality or multiple-modality imaging workstations at the same or different physical locations without loss of subject positional information. The animal holder is compatible with preclinical animal imaging stations such as micro-CT, micro-MR, micro-PET, micro-SPECT, and FMT. The animal holder is configured to be accommodated by (for example, fit within) individual imaging chambers of such instruments and is fabricated from materials that are compliant with all of the imaging modalities used. In certain embodiments, an integrated set of fiducial marker wells accommodates the dispensing of markers that are picked up by several modalities simultaneously in multiple planes. The fiducial markers then are aligned in standard image processing or image analysis software with simple image translation and rotation operations, without the need for more advanced scaling, distortion or other operations.Type: GrantFiled: March 25, 2009Date of Patent: December 23, 2014Assignee: VisEn Medical, Inc.Inventors: Wael I. Yared, Andrew K. Wilson
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Publication number: 20140243661Abstract: In certain embodiments, the invention relates to systems and methods for altering an image to compensate for variation in one or more physical and/or supervenient properties (e.g., optical absorption and/or scattering) in heterogeneous, diffuse tissue, thereby attenuating the effects of tissue waveguiding. The methods enable the proper identification of emission image regions that evidence waveguiding of electromagnetic radiation, and enables compensation of emission images for such waveguiding. The methods preserve the depth localization accuracy of the FMT approach and improve optical reconstruction in the targeted areas while eliminating spurious components of fluorescence from the acquired data set. Calibration methods for probe concentration mapping are also presented.Type: ApplicationFiled: February 14, 2014Publication date: August 28, 2014Applicant: VisEn Medical, Inc.Inventors: Wael I. Yared, Pouyan Mohajerani, Joshua Kempner
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Patent number: 8653480Abstract: In certain embodiments, the invention relates to systems and methods for altering an image to compensate for variation in one or more physical and/or supervenient properties (e.g., optical absorption and/or scattering) in heterogeneous, diffuse tissue, thereby attenuating the effects of tissue waveguiding. The methods enable the proper identification of emission image regions that evidence waveguiding of electromagnetic radiation, and enables compensation of emission images for such waveguiding. The methods preserve the depth localization accuracy of the FMT approach and improve optical reconstruction in the targeted areas while eliminating spurious components of fluorescence from the acquired data set. Calibration methods for probe concentration mapping are also presented.Type: GrantFiled: June 20, 2013Date of Patent: February 18, 2014Assignee: VisEn Medical, Inc.Inventors: Wael I. Yared, Pouyan Mohajerani, Joshua Kempner
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Publication number: 20140003692Abstract: In certain embodiments, the invention relates to systems and methods for altering an image to compensate for variation in one or more physical and/or supervenient properties (e.g., optical absorption and/or scattering) in heterogeneous, diffuse tissue, thereby attenuating the effects of tissue waveguiding. The methods enable the proper identification of emission image regions that evidence waveguiding of electromagnetic radiation, and enables compensation of emission images for such waveguiding. The methods preserve the depth localization accuracy of the FMT approach and improve optical reconstruction in the targeted areas while eliminating spurious components of fluorescence from the acquired data set. Calibration methods for probe concentration mapping are also presented.Type: ApplicationFiled: June 20, 2013Publication date: January 2, 2014Applicant: VisEn Medical, Inc.Inventors: Wael I. Yared, Pouyan Mohajerani, Joshua Kempner
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Patent number: 8492734Abstract: In certain embodiments, the invention relates to systems and methods for altering an image to compensate for variation in one or more physical and/or supervenient properties (e.g., optical absorption and/or scattering) in heterogeneous, diffuse tissue, thereby attenuating the effects of tissue waveguiding. The methods enable the proper identification of emission image regions that evidence waveguiding of electromagnetic radiation, and enables compensation of emission images for such waveguiding. The methods preserve the depth localization accuracy of the FMT approach and improve optical reconstruction in the targeted areas while eliminating spurious components of fluorescence from the acquired data set. Calibration methods for probe concentration mapping are also presented.Type: GrantFiled: June 3, 2008Date of Patent: July 23, 2013Assignee: VisEn Medical, Inc.Inventors: Wael I. Yared, Pouyan Mohajerani, Joshua Kempner
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Patent number: 8401618Abstract: The invention relates to systems and methods for tomographic imaging in diffuse media employing a fast reconstruction technique. A hybrid Fourier approach is presented that enables the fast tomographic reconstruction of large datasets. In certain embodiments, the invention features methods of in vivo fluorescence molecular tomographic (FMT) reconstruction of signals, reporters and/or agents (i.e., contrast agents or probes) in a diffusive medium (e.g., a mammalian subject). The method preserves the three-dimensional fluorophore distribution and quantitative nature of the FMT approach while substantially accelerating its computation speed, allowing FMT imaging of larger anatomies.Type: GrantFiled: August 27, 2010Date of Patent: March 19, 2013Assignee: VisEn Medical, Inc.Inventors: Jorge Ripoll Lorenzo, Wael I. Yared, Joshua Kempner
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Patent number: 8401619Abstract: The invention relates to systems and methods for tomographic imaging of a subject comprising diffuse media by converting measurements of electromagnetic radiation, e.g., fluorescent light, obtained in free space exterior to the subject into data that would be measured if the subject were surrounded by an infinite and homogeneous diffusive medium, e.g., a medium with optical properties equal to the average optical properties of the subject. After applying a transformation to convert measurements to virtually-matched values, propagation of light is simulated from the index-matched surface to a set of virtual detectors exterior to the subject and arranged in a geometrically advantageous fashion, for example, in a planar array, thereby facilitating the use of fast reconstruction techniques.Type: GrantFiled: September 22, 2010Date of Patent: March 19, 2013Assignee: VisEn Medical, Inc.Inventors: Jorge Ripoll Lorenzo, Wael I. Yared, Joshua Kempner
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Publication number: 20110184277Abstract: The invention relates to systems and methods for tomographic imaging of a subject comprising diffuse media by converting measurements of electromagnetic radiation, e.g., fluorescent light, obtained in free space exterior to the subject into data that would be measured if the subject were surrounded by an infinite and homogeneous diffusive medium, e.g., a medium with optical properties equal to the average optical properties of the subject. After applying a transformation to convert measurements to virtually-matched values, propagation of light is simulated from the index-matched surface to a set of virtual detectors exterior to the subject and arranged in a geometrically advantageous fashion, for example, in a planar array, thereby facilitating the use of fast reconstruction techniques.Type: ApplicationFiled: September 22, 2010Publication date: July 28, 2011Inventors: Jorge Ripoll Lorenzo, Wael I. Yared, Joshua Kempner
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Publication number: 20110071388Abstract: The invention facilitates transport of an immobilized, anesthetized small animal across multiple single-modality or multiple-modality imaging workstations at the same or different physical locations without loss of subject positional information. The animal holder is compatible with preclinical animal imaging stations such as micro-CT, micro-MR, micro-PET, micro-SPECT, and FMT. The animal holder is configured to be accommodated by (for example, fit within) individual imaging chambers of such instruments and is fabricated from materials that are compliant with all of the imaging modalities used. In certain embodiments, an integrated set of fiducial marker wells accommodates the dispensing of markers that are picked up by several modalities simultaneously in multiple planes. The fiducial markers then are aligned in standard image processing or image analysis software with simple image translation and rotation operations, without the need for more advanced scaling, distortion or other operations.Type: ApplicationFiled: March 25, 2009Publication date: March 24, 2011Inventors: Wael I. Yared, Andrew K. Wilson
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Publication number: 20110060211Abstract: The invention relates to systems and methods for tomographic imaging in diffuse media employing a fast reconstruction technique. A hybrid Fourier approach is presented that enables the fast tomographic reconstruction of large datasets. In certain embodiments, the invention features methods of in vivo fluorescence molecular tomographic (FMT) reconstruction of signals, reporters and/or agents (i.e., contrast agents or probes) in a diffusive medium (e.g., a mammalian subject). The method preserves the three-dimensional fluorophore distribution and quantitative nature of the FMT approach while substantially accelerating its computation speed, allowing FMT imaging of larger anatomies.Type: ApplicationFiled: August 27, 2010Publication date: March 10, 2011Inventors: Jorge Ripoll Lorenzo, Wael I. Yared, Joshua Kempner
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Publication number: 20110049384Abstract: In certain embodiments, the invention relates to systems and methods for altering an image to compensate for variation in one or more physical and/or supervenient properties (e.g., optical absorption and/or scattering) in heterogeneous, diffuse tissue, thereby attenuating the effects of tissue waveguiding. The methods enable the proper identification of emission image regions that evidence waveguiding of electromagnetic radiation, and enables compensation of emission images for such waveguiding. The methods preserve the depth localization accuracy of the FMT approach and improve optical reconstruction in the targeted areas while eliminating spurious components of fluorescence from the acquired data set. Calibration methods for probe concentration mapping are also presented.Type: ApplicationFiled: June 3, 2008Publication date: March 3, 2011Inventors: Wael I. Yared, Pouyan Mohajerani, Joshua Kempner