Patents by Inventor Wahajul Haq

Wahajul Haq has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMAC MIMETICS FOR TREATMENT OF CANCER, PROCESS FOR PREPARATION AND PHARMACEUTICAL COMPOSITION THEREOF
    Publication number: 20240083846
    Abstract: The present invention relates to novel SMAC mimetic peptidomimetics useful for the treatment of proliferative diseases including cancer in mammals The novel SMAC mimetics are prepared by incorporating (2S,5R)-5-(5-methylfuran-2-yl)pyrrolidine-2-carboxylic acid, a novel unnatural amino acid that imparts exclusively trans amide bond geometry favourable for target protein binding. Here, the novel SMAC mimetic molecule(s) not only show its efficacy in varied cancer types but also demonstrate in vitro and in vivo efficacy against therapy resistant cancer as a single agent. The novel SMAC mimetics disclosed in the present invention binds to BIR-2 and BIR-3 domains of the XIAP and exhibit high anti-proliferative activity against variety of mammalian cancer cell lines that include but not limited to chemotherapy and TRAIL resistant cell lines.
    Type: Application
    Filed: December 17, 2021
    Publication date: March 14, 2024
    Inventors: Wahajul HAQ, Rafat ALI, Akhilesh SINGH, Mushtaq Ahmad NENGROO, Roshan KATEKAR, Gajendra SINGH, Jayanti VAISHNAV, Mohammad AFSAR, Manohar SINGH, Srikanta Kumar RATH, Dipankar KOLEY, Durga Prasad MISHRA, Ravishankar RAMACHANDRAN, Ravi Sankar AMPAPATHI, Jiaur Rahaman GAYEN, Dipak DATTA
  • Polypeptides useful for diagnosis of Aspergillus fumigatus and a process of preparing the same
    Patent number: 6902901
    Abstract: The present invention relates to novel peptide sequences from the immunodominant region of an 18 kD major allergen/antigen of Aspergillus fumigatus from aa 6-22, comprising aa 10-20, aa 6-20, aa 14-20, aa 10-22, aa 6-13 and the peptide sequence resulting from the modification by substitution and/or by addition and/or deletion of one or more amino acid altering specified properties.
    Type: Grant
    Filed: June 4, 2001
    Date of Patent: June 7, 2005
    Assignee: Council of Scientific and Industrial Research
    Inventors: Puranam U. Sarma, Taruna Madan, Priyanka Priyadarsiny, Seturan B. Katti, Wahajul Haq
  • Inclusion complees of a high potent opioid peptide, pharmaceutical compositions and method of treatment
    Patent number: 6740639
    Abstract: The invention provides novel inclusion complexes of highly potent opioid peptide of L-Tyrosyl-D-alanyl-glycyl-N-methylphenylalanyl-glycyl-isopropylamide with cyclodextrin, pharmaceutical preparations containing these inclusion complexes of L-Tyrosyl-D-alanyl-glycyl-N-methylphenylalanyl-glycyl-isopropylamide with cyclodextrin derivatives, the complexes being better soluble in water and having improved biopharmaceutical properties such as lesser toxicity, better analgesic action and non-addiction properties.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: May 25, 2004
    Assignee: Council of Scientific & Industrial Research
    Inventors: Anil Kumar Dwivedi, Madhu Khanna, Wahajul Haq, Ram Raghubir, Sudhir Srivastava, Puvvada Sri Ramchandra Murthy, Onkar Prasad Asthana, Jagdishwar Sahay Srivastava, Satyawan Singh
  • Linker based solid support for peptide and small molecule organic synthesis
    Patent number: 6492460
    Abstract: The present invention relates to a novel linker based solid support, methods for generating the linker moiety on the solid support, and methods of using the supports to synthesize peptides and small molecule combinatorial library and the new solid support of this invention also comprises a functionalized linker covalently attached to the solid supports such as polystyrene.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: December 10, 2002
    Assignee: Council of Scientific and Industrial Research
    Inventors: Wahajul Haq, Seturam Bandhacharya Katti
  • LINKER BASED SOLID SUPPORT FOR PEPTIDE AND SMALL MOLECULE ORGANIC SYNTHESIS
    Publication number: 20020147297
    Abstract: The present invention relates to a novel linker based solid support, methods for generating the linker moiety on the solid support, and methods of using the supports to synthesize peptides and small molecule combinatorial library and the new solid support of this invention also comprises a functionalized linker covalently attached to the solid supports such as polystyrene.
    Type: Application
    Filed: January 26, 2001
    Publication date: October 10, 2002
    Inventors: Wahajul Haq, Seturam Bandhacharya Katti
  • Novel polypeptides useful for diagnosis of Aspergillus fumigatus and a process of preparing the same
    Publication number: 20020061544
    Abstract: The present invention relates to novel peptide sequences from the immunodominant region of an 18 kD major allergen/antigen of Aspergillus fumigatus from aa 6 - 22, comprising aa 10 -20, aa 6-20, aa 14-20, aa 10-22, aa 6-13 and the peptide sequence resulting from the modification by substitution and/or by addition and/ or deletion of one or more amino acid altering specified properties.
    Type: Application
    Filed: June 4, 2001
    Publication date: May 23, 2002
    Applicant: Council of Scientific Industrial Research
    Inventors: Puranam U. Sarma, Taruna Madan, Priyanka Priyadarsiny, Seturan B. Katti, Wahajul Haq
  • Polypeptides useful for diagnosis of Aspergillus fumigatus and a process of preparing the same
    Patent number: 6262231
    Abstract: The present invention relates to novel peptide sequences from the immunodominant region of an 18 kD major allergen/antigen of Aspergillus fumigatus from aa 6-22, comprising aa 10-20, aa 6-20, aa 14-20, aa 10-22, aa 6-13 and the peptide sequence resulting from the modification by substitution and/or by addition and/or deletion of one or more amino acid altering specified properties.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: July 17, 2001
    Assignee: Council of Scientific and Industrial Research
    Inventors: Puranam U. Sarma, Taruna Madan, Priyanka Priyadarsiny, Seturan B. Katti, Wahajul Haq