Patents by Inventor Wai Kei OR
Wai Kei OR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240011105Abstract: Various embodiments are directed to detecting infection-causing microbial cell-free DNA from a biological sample based on their size profiles and/or end signatures, in which the detection of infection-causing microbial DNA can be performed without no template control (NTC) samples. Embodiments can include identifying the infection-causing pathogen-derived microbial DNA based on sizes of microbial cell-free DNA molecules. Embodiments can also include identifying from the infection-causing pathogen-derived microbial DNA based on end signatures of microbial cell-free DNA molecules. Embodiments can also include applying a machine-learning algorithm to a plurality of vectors that represent end signatures of the microbial cell-free DNA molecules, to identify the infection-causing pathogen-derived microbial DNA. By detecting the infection-causing pathogen-derived microbial DNA, a level of infection for the biological sample can be predicted.Type: ApplicationFiled: July 8, 2022Publication date: January 11, 2024Inventors: Yuk-Ming Dennis Lo, Kwan Chee Chan, Rossa Wai Kwun Chiu, Wai Kei Lam, Peiyong Jiang, Guangya Wang
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Publication number: 20230342532Abstract: The present disclosure provides a method and an apparatus for arranging electrical components within a semiconductor device, and a non-transitory computer-readable medium. The method includes (a) placing a plurality of cells in a first layout, wherein the first layout includes a first row and a second row adjacent to the first row; (b) dividing the first layout into a plurality of regions; (c) calculating a first density of each of the plurality of regions; (d) calculating, for a first region of the plurality of regions, a first probability of altering cell versions for cells in the first region according to the first density of the first region; (e) altering cell versions of one or more cells in the first region according to a comparison between the first probability and a first threshold; and (f) rearranging the cells in the first layout to reduce cell overlap.Type: ApplicationFiled: April 26, 2022Publication date: October 26, 2023Inventors: WAI-KEI MAK, TING-CHI WANG, TSU-LING HSIUNG, HSUAN-HAN LIANG, SHENG-HSIUNG CHEN
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Patent number: 11741286Abstract: A method (of generating a layout diagram) includes identifying, in the layout diagram, a group of three or more cells arranged so as to exhibit two or more edge-pairs (EPs) that are edge-wise abutted relative to a first direction. The method further includes, for each of at least one but fewer than all of the three or more cells, selectively moving a given one of cells corresponding to one of the members of the corresponding EP resulting in at least a minimum gap in the first direction between the members of the corresponding EP.Type: GrantFiled: July 1, 2021Date of Patent: August 29, 2023Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY, LTD.Inventors: Meng-Kai Hsu, Sheng-Hsiung Chen, Wai-Kei Mak, Ting-Chi Wang, Yu-Hsiang Cheng, Ding-Wei Huang
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Publication number: 20230244845Abstract: The present disclosure provides a method and an apparatus for arranging electrical components within a semiconductor device, and a non-transitory computer-readable medium. The method includes (a) placing a plurality of cells in a first layout; (b) generating a second layout by performing a first set of calculations on the first layout such that a total wire length of the second layout is less than that of the first layout; (c) generating a third layout by performing a second set of calculations on the second layout such that cell congestions in the second layout is eliminated from the third layout; (d) generating a fourth layout by performing a third set of calculations on the third layout such that the total wire length of the fourth layout is less than that of the third layout; and (e) iterating the operations (c) and (d) until a target layout conforms to a convergence criterion.Type: ApplicationFiled: January 28, 2022Publication date: August 3, 2023Inventors: TING-CHI WANG, WAI-KEI MAK, KUAN-YU CHEN, HSIU-CHU HSU, HSUAN-HAN LIANG, SHENG-HSIUNG CHEN
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Publication number: 20230177521Abstract: A computer-implemented method for compliance checking related to goods in import supply chain logistics is provided, including: adding received legality data elements into a blockchain ledger corresponding to an importation of the goods; establishing a smart contract of the blockchain ledger; adding received sensing data elements corresponding to the smart contract into the blockchain ledger; adding electronic lock (e-Lock) status data corresponding to the smart contract into the blockchain ledger; and adding one or more inspection results corresponding to the smart contract into the blockchain ledger. Furthermore, determining, by the smart contract, whether the goods are within the compliance according to the received legality data elements, the received sensing data elements, the e-Lock status data and the one or more inspection results, wherein in response to determining that the goods are within the compliance, unsealing the e-Locks by sending a control signal to the e-Locks.Type: ApplicationFiled: December 6, 2021Publication date: June 8, 2023Inventors: Wai Kei Ricky LEUNG, Shing Yee CHU, Chi Keung WONG, Tsz Fung LEUNG, Samuel Chen Ying NG
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Publication number: 20230151436Abstract: Various embodiments are directed to applications (e.g., classification of biological samples) of the analysis of the count, the fragmentation patterns, and size of cell-free nucleic acids, e.g., plasma DNA and serum DNA, including nucleic acids from pathogens, such as viruses. Embodiments of one application can determine if a subject has a particular condition. For example, a method of present disclosure can determine if a subject has cancer or a tumor, or other pathology. Embodiments of another application can be used to assess the stage of a condition, or the progression of a condition over time. For example, a method of the present disclosure may be used to determine a stage of cancer in a subject, or the progression of cancer in a subject over time (e.g., using samples obtained from a subject at different times).Type: ApplicationFiled: October 18, 2022Publication date: May 18, 2023Inventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Wai Kei Lam
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Publication number: 20230132951Abstract: Methods are provided to improve the positive predictive value for cancer detection using cell-free nucleic acid samples. Various embodiments are directed to applications (e.g., diagnostic applications) of the analysis of the fragmentation patterns and size of cell-free DNA, e.g., plasma DNA and serum DNA, including nucleic acids from pathogens, including viruses. Embodiments of one application can determine if a subject has a particular condition. For example, a method of present disclosure can determine if a subject has cancer or a tumor, or other pathology. Embodiments of another application can be used to assess the stage of a condition, or the progression of a condition over time. For example, a method of the present disclosure may be used to determine a stage of cancer in a subject, or the progression of cancer in a subject over time (e.g., using samples obtained from a subject at different times).Type: ApplicationFiled: August 9, 2022Publication date: May 4, 2023Inventors: Eugeni Namsaraev, Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Kun Sun, Wai Kei Lam
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Publication number: 20230103637Abstract: Various embodiments are directed to applications (e.g., classification of biological samples) of the analysis of the count and size of cell-free nucleic acids, e.g., plasma DNA and serum DNA, including nucleic acids from pathogens, such as viruses. Embodiments of one application can predict if a subject previously treated for a pathology will relapse at a future time point. Targeted sequencing (e.g., specifically designed capture probes, amplification primers) can be used to identify DNA across the entire viral genome.Type: ApplicationFiled: September 30, 2022Publication date: April 6, 2023Inventors: Yuk-Ming Dennis Lo, Kwan Chee Chan, Wai Kei Lam, Chiu Tung Chan
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Publication number: 20220380855Abstract: Provided herein are methods and systems for identifying chimeric nucleic acid fragments, e.g., organism-pathogen chimeric nucleic acid fragments and chromosomal rearrangement chimeric nucleic acid fragments. Also provided herein are methods and systems relating to determining a pathogen integration profile or a chromosomal rearrangement in a biological sample and determining a classification of pathology based at least in part on a pathogen integration profile or a chromosomal rearrangement in a biological sample. In certain aspects of the present disclosure, cell-free nucleic acid molecules from a biological sample are analyzed.Type: ApplicationFiled: July 29, 2022Publication date: December 1, 2022Inventors: Yuk-Ming Dennis LO, Rossa Wai Kwun CHIU, Kwan Chee CHAN, Peiyong JIANG, Wai Kei LAM, Haiqiang ZHANG
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Patent number: 11479825Abstract: Various embodiments are directed to applications (e.g., classification of biological samples) of the analysis of the count, the fragmentation patterns, and size of cell-free nucleic acids, e.g., plasma DNA and serum DNA, including nucleic acids from pathogens, such as viruses. Embodiments of one application can determine if a subject has a particular condition. For example, a method of present disclosure can determine if a subject has cancer or a tumor, or other pathology. Embodiments of another application can be used to assess the stage of a condition, or the progression of a condition over time. For example, a method of the present disclosure may be used to determine a stage of cancer in a subject, or the progression of cancer in a subject over time (e.g., using samples obtained from a subject at different times).Type: GrantFiled: April 24, 2020Date of Patent: October 25, 2022Assignees: The Chinese University of Hong Kong, GRAIL, Inc.Inventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Wai Kei Lam
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Patent number: 11459616Abstract: Methods are provided to improve the positive predictive value for cancer detection using cell-free nucleic acid samples. Various embodiments are directed to applications (e.g., diagnostic applications) of the analysis of the fragmentation patterns and size of cell-free DNA, e.g., plasma DNA and serum DNA, including nucleic acids from pathogens, including viruses. Embodiments of one application can determine if a subject has a particular condition. For example, a method of present disclosure can determine if a subject has cancer or a tumor, or other pathology. Embodiments of another application can be used to assess the stage of a condition, or the progression of a condition over time. For example, a method of the present disclosure may be used to determine a stage of cancer in a subject, or the progression of cancer in a subject over time (e.g., using samples obtained from a subject at different times).Type: GrantFiled: October 25, 2017Date of Patent: October 4, 2022Assignees: The Chinese University of Hong Kong, GRAIL, Inc.Inventors: Eugeni Namsaraev, Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Kun Sun, Wai Kei Lam
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Patent number: 11447829Abstract: Provided herein are methods and systems for identifying chimeric nucleic acid fragments, e.g., organism-pathogen chimeric nucleic acid fragments and chromosomal rearrangement chimeric nucleic acid fragments. Also provided herein are methods and systems relating to determining a pathogen integration profile or a chromosomal rearrangement in a biological sample and determining a classification of pathology based at least in part on a pathogen integration profile or a chromosomal rearrangement in a biological sample. In certain aspects of the present disclosure, cell-free nucleic acid molecules from a biological sample are analyzed.Type: GrantFiled: June 28, 2019Date of Patent: September 20, 2022Assignee: GRAIL, LLCInventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Wai Kei Lam, Haiqiang Zhang
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Patent number: 11268174Abstract: This invention provides a jewelry alloy which improves mechanical properties of AuIn2 while preserving its attractive blue hue. In one embodiment, said mechanical properties comprises fracture toughness and hardness. In one embodiment, said jewelry alloy consist essentially of 43.0 to 49.0 wt % Au; 51.0 to 57.0 wt % In; 0.001 to 1.0 wt % of one or more elements selected from the group consisting of Fe and Ge; and 0.001 to 1.0 wt % of one or more elements selected from the group consisting of Rh, Ir and Ru.Type: GrantFiled: July 22, 2021Date of Patent: March 8, 2022Assignee: CHOW SANG SANG JEWELLERY COMPANY LIMITEDInventors: Wai Kei Cheung, Shuk Kwan Mak, Mei Tsz Macy WONG
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Publication number: 20220010353Abstract: Various embodiments are directed to using nuclease expression in tissues that influences cell-free DNA end signatures/motifs and size of overhang between DNA strands. Embodiments can identify a nuclease that is being differentially regulated in abnormal cells relative to normal cells. Embodiments can determine that the nuclease preferentially cuts DNA into DNA molecules having: (i) a particular sequence end signature; or (ii) a specified length of overhang between a first strand and a second strand. A parameter can be determined for a biological sample based on an amount of DNA molecules that include an end sequence corresponding to the particular sequence end signature and/or a measured property correlating to the specified length of overhang. The parameter can be used to determine a characteristic of a tissue type, a fractional concentration of clinically-relevant DNA molecules, or a level of abnormality of a tissue type in the biological sample.Type: ApplicationFiled: July 13, 2021Publication date: January 13, 2022Inventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Wing Yan Chan, Wai Kei Lam, Diana Siao Cheng Han, Wenlei Peng, Chen Ding
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Publication number: 20210326510Abstract: A method (of generating a layout diagram) includes identifying, in the layout diagram, a group of three or more cells arranged so as to exhibit two or more edge-pairs (EPs) that are edge-wise abutted relative to a first direction. The method further includes, for each of at least one but fewer than all of the three or more cells, selectively moving a given one of cells corresponding to one of the members of the corresponding EP resulting in at least a minimum gap in the first direction between the members of the corresponding EP.Type: ApplicationFiled: July 1, 2021Publication date: October 21, 2021Inventors: Meng-Kai HSU, Sheng-Hsiung CHEN, Wai-Kei MAK, Ting-Chi WANG, Yu-Hsiang CHENG, Ding-Wei HUANG
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Patent number: 11062076Abstract: A method (of generating a layout diagram) includes: identifying, in the layout diagram, a group of three or more cells which violates a horizontal constraint vector (HCV) and is arranged so as to exhibit two or more vertically-aligned edge-pairs (VEPs); each VEP including two members representing at least partial portions of vertical edges of corresponding cells of the group; relative to a horizontal direction, the members of each VEP being disposed in edgewise-abutment and separated by a corresponding actual gap; and the HCV having separation thresholds, each of which has a corresponding VEP and represents a corresponding minimum gap in the horizontal direction between the members of the corresponding VEP; and for each of at least one but fewer than all of the separation thresholds, selectively moving a given one of cells corresponding to one of the members of the corresponding VEP thereby to avoid violating the HCV.Type: GrantFiled: August 19, 2020Date of Patent: July 13, 2021Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY LTD.Inventors: Meng-Kai Hsu, Sheng-Hsiung Chen, Wai-Kei Mak, Ting-Chi Wang, Yu-Hsiang Cheng, Ding-Wei Huang
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Patent number: 10977756Abstract: A location based Quality Assurance System and a method to collect data in work spaces in terms of locations, environment conditions, time, workers and behaviours, thru the wireless interactions (M2M) of located and installed sensors on sites and PPE with detachable or built-in sensors, which data wirelessly transmitted to remote servers for big data analysis in order to enhance effective communication and management of safety, work flow, work forces, worker attendance and project in work spaces.Type: GrantFiled: October 12, 2016Date of Patent: April 13, 2021Assignee: Infotronic Technology LimitedInventors: Kwong Yip Cheng, Kam Chuen Yeung, Wai Kei Leung, Kwok Shing Leung
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Publication number: 20200380194Abstract: A method (of generating a layout diagram) includes: identifying, in the layout diagram, a group of three or more cells which violates a horizontal constraint vector (HCV) and is arranged so as to exhibit two or more vertically-aligned edge-pairs (VEPs); each VEP including two members representing at least partial portions of vertical edges of corresponding cells of the group; relative to a horizontal direction, the members of each VEP being disposed in edgewise-abutment and separated by a corresponding actual gap; and the HCV having separation thresholds, each of which has a corresponding VEP and represents a corresponding minimum gap in the horizontal direction between the members of the corresponding VEP; and for each of at least one but fewer than all of the separation thresholds, selectively moving a given one of cells corresponding to one of the members of the corresponding VEP thereby to avoid violating the HCV.Type: ApplicationFiled: August 19, 2020Publication date: December 3, 2020Inventors: Meng-Kai HSU, Sheng-Hsiung CHEN, Wai-Kei MAK, Ting-Chi WANG, Yu-Hsiang CHENG, Ding-Wei HUANG
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Publication number: 20200325546Abstract: Cell-free DNA molecules in a mixture of a biological sample can be analyzed to detect viral DNA. Methylation of viral DNA molecules at one or more sites in the viral genome can be determined. Mixture methylation level(s) can be measured based on one or more amounts of the plurality of cell-free DNA molecules methylated at a set of site(s) of the particular viral genome. The mixture methylation level(s) can be determined in various ways, e.g., as a density of cell-free DNA molecules that are methylated at a site or across multiple sites or regions. The mixture methylation level(s) can be compared to reference methylation level(s), e.g., determined from at least two cohorts of other subjects. The cohorts can have different classifications (including the first condition) associated with the particular viral genome. A first classification of whether the subject has the first condition can be determined based on the comparing.Type: ApplicationFiled: June 25, 2020Publication date: October 15, 2020Inventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Wai Kei Lam
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Publication number: 20200318204Abstract: Various embodiments are directed to applications (e.g., classification of biological samples) of the analysis of the count, the fragmentation patterns, and size of cell-free nucleic acids, e.g., plasma DNA and serum DNA, including nucleic acids from pathogens, such as viruses. Embodiments of one application can determine if a subject has a particular condition. For example, a method of present disclosure can determine if a subject has cancer or a tumor, or other pathology. Embodiments of another application can be used to assess the stage of a condition, or the progression of a condition over time. For example, a method of the present disclosure may be used to determine a stage of cancer in a subject, or the progression of cancer in a subject over time (e.g., using samples obtained from a subject at different times).Type: ApplicationFiled: April 24, 2020Publication date: October 8, 2020Inventors: Yuk-Ming Dennis Lo, Rossa Wai Kwun Chiu, Kwan Chee Chan, Peiyong Jiang, Wai Kei Lam