Patents by Inventor Walajapet G. Rajeswaran
Walajapet G. Rajeswaran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7408024Abstract: The present invention is directed to a somatostatin antagonist according to formula (I): A1-cyclo {D-Cys-A2-D-Trp-A3-A4-Cys}-A5Y1, wherein A1 is an optionally substituted aromatic a-amino acid; A2 is an optionally substituted aromatic ?-amino acid; A3 is Dab, Dap, Lys or Om; A4 is ?-Hydroxyvaline, Ser, Hser, or Thr; A5 is an optionally substituted D- or L-aromatic amino acid; and Y1 is OH, NH2 or NHR1? where RI is (C1-6)alkyl; wherein each said optionally substituted aromatic amino acid is optionally substituted with one or more substituents each independently selected from the group consisting of halogen, NO2, OH, CN, (C1-6) alkyl, (C2-6) alkenyl, (C2-6) alkynyl, (C1-6)alkoxy, Bzl, O-Bzl, and NR9R10? wherein R9 ad R10 each is independently H, O, or (C1-6) alkyl; and wherein the amine nitrogen of each of amide peptide bond and the amino group of A1 of formula (I) is optionally substituted with a methyl group, provided that there is at least one said methyl group; or a pharmaceutically acceptable salt thereof,Type: GrantFiled: August 20, 2007Date of Patent: August 5, 2008Assignee: The Administrators of the Tulane Educational FundInventors: David H. Coy, William A. Murphy, Walajapet G. Rajeswaran
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Publication number: 20080171853Abstract: The present invention is directed to a method for synthesizing a peptide using solid-state chemistry in which at least one amide bond is N-methylated, wherein said method of synthesis utilizes N-Boc protected amino acids. For example, the a peptide is first synthesized using N-BOC protected amino acids and 4-methylbenzylhydrylamine functionalized 1% cross linked polystyrene resin until reaching the amide bond to be N-methylated. Then, the amino group at the desired methylation site is methylated. If desired, the synthesis of additional peptide using N-BOC protected amino acids may continued until the desired peptide is complete.Type: ApplicationFiled: March 11, 2008Publication date: July 17, 2008Inventors: David H. Coy, Wiliam A. Murphy, Walajapet G. Rajeswaran
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Patent number: 7378488Abstract: The present invention is directed to a somatostatin antagonist according to formula (I), wherein A1 is an optionally substituted aromatic ?-amino acid; A2 is an optionally substituted aromatic ?-amino acid; A3 is Dab, Dap, Lys or Orn; A4 is ?-Hydroxyvaline, Ser, Hser, or Thr; A5 is an optionally substituted D- or L-aromatic -amino acid; and Y1 is OH, NH2 or NHR1, or NHR1, where R1 is (C1-6)alkyl; wherein each said optionally substituted aromatic -amino acid is optionally substituted with one or more substituents substituents each independently selected from the group consisting of halogen, NO2, OH, CN, (C1-6)alkyl, (c2-6)alkenyl, (c2-6)alkynyl, (C1-6)alkoxy, Bzl, O-Bzl, and NR9R10, where R9 ad R10 each is independently H, O, or (C1-6)alkyl; and wherein the amine nitrogen of each of amide peptide bond and the amino group of A1 of formula (I) is optionally substituted with a methyl group, provided that there is at least one said methyl group; or a pharmaceutically acceptable salt thereof, and to uses thereof.Type: GrantFiled: March 5, 2002Date of Patent: May 27, 2008Assignee: The Administrators of the Tulane Educational FundInventors: David H. Coy, William A. Murphy, Walajapet G. Rajeswaran
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Patent number: 7312304Abstract: Claimed are a series of somatostatin agonists and uses thereof, according to formula (I), A1-cyclo[Cys-A2-D-Trp-A3-A4-Cys]-A5-Y1, ??(I) wherein A1, A2, A3, A4, A5 and Y1 are as defined in specification provided that the amine nitrogen of at least one peptide bond is substituted with a methyl group or pharmaceutically acceptable salts thereof.Type: GrantFiled: April 8, 2002Date of Patent: December 25, 2007Assignee: The Administrators of the Tulane Educational FundInventors: David H. Coy, Walajapet G. Rajeswaran
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Publication number: 20040181032Abstract: The present invention is directed to a somatostatin antagonist according to formula (I), wherein A1 is an optionally substituted aromatic ∝-amino acid; A2 is an optionally substituted aromatic ∝-amino acid; A3 is Dab, Dap, Lys or Orn; A4 is &bgr;-Hydroxyvaline, Ser, Hser, or Thr; A5 is an optionally substituted D- or L-aromatic -amino acid; and Y1 is OH, NH2 or NHR1, where R1 is (C1-6)alkyl; wherein each said optionally substituted aromatic -amino acid is optionally substituted with one or more substituents each independently selected from the group consisting of halogen, NO2, OH, CN, (C1-6)alkyl, (c2-6)alkenyl, (c2-6)alkynyl, (C1-6)alkoxy, Bzl, O-Bzl, and NR9R10, where R9 ad R10 each is independently H, O, or (C1-6)alkyl; and wherein the amine nitrogen of each of amide peptide bond and the amino group of A1 of formula (I) is optionally substituted with a methyl group, provided that there is at least one said methyl group; or a pharmaceutically acceptable salt thereof, and to uses thereof.Type: ApplicationFiled: February 24, 2004Publication date: September 16, 2004Inventors: David H. Coy, William A. Murphy, Walajapet G. Rajeswaran
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Publication number: 20040171530Abstract: Claimed are a series of somatostatin agonists typically characterized by alkylation of the amide nitrogen, and uses thereof.Type: ApplicationFiled: April 26, 2004Publication date: September 2, 2004Inventors: David H. Coy, Walajapet G. Rajeswaran
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Patent number: 6369081Abstract: A compound of Formula (I): wherein R is a linkage independently selected from (CH2)12 or (CH2)4O3; and acid addition salts, solvates and hydrates thereof. The compounds have unusually high affinity for muscarinic receptors, and exhibit agonist activity useful in the treatment of neurological and other disorders, in which stimulating cholinergic activity is desirable.Type: GrantFiled: July 31, 2000Date of Patent: April 9, 2002Assignee: The University of ToledoInventors: Walajapet G. Rajeswaran, William S. Messer
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Patent number: 6211204Abstract: A compound of Formula (I): wherein R is independently selected from (CH2)9−12, (CH2CH2)2O, (CH2CH2)3O2, (CH2CH2)4O3, (CH2CH2)5O4, (CH2CH2)6O5 or (CH2CH2CH2)3O2; or an acid addition salt or hydrate thereof. The compounds, with improved water solubility, have unusually high affinity for muscarinic receptors, and exhibit agonist activity useful in the treatment of neurological and other disorders, in which stimulating cholinergic activity is desirable.Type: GrantFiled: January 14, 2000Date of Patent: April 3, 2001Assignee: University of ToledoInventors: William S. Messer, Yang Cao, Walajapet G. Rajeswaran
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Patent number: 6096767Abstract: A compound of Formula (I): ##STR1## wherein R is a linkage independently selected from (CH.sub.2).sub.12 or (CH.sub.2).sub.4 O.sub.3 ; and acid addition salts, solvates and hydrates thereof. The compounds have unusually high affinity for muscarinic receptors, and exhibit agonist activity useful in the treatment of neurological and other disorders, in which stimulating cholinergic activity is desirable.Type: GrantFiled: January 22, 1999Date of Patent: August 1, 2000Assignee: The University of ToledoInventors: Walajapet G. Rajeswaran, William S. Messer