Patents by Inventor Waleed Danho

Waleed Danho has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Neuropeptide-2 receptor (Y-2R) agonists and uses thereof
    Patent number: 7642244
    Abstract: Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. X is 4-oxo-6-(1-piperazinyl)-3(4H)-quinazoline-acetic acid (Pqa). These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: January 5, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Karin Conde-Knape, Waleed Danho, George Ehrlich, Nader Fotouhi, David Charles Fry, Wajiha Khan, Anish Konkar, Cristina Martha Rondinone, Joseph Swistok, Rebecca Anne Taub, Jefferson Wright Tilley
  • Neuropeptide-2 receptor (Y-2R) agonists and uses thereof
    Patent number: 7410949
    Abstract: Provided herein are neuropeptide-2 receptor agonists of the formula (I): Y—R1—R2—X—R3—R4—R5—R6—R7—R8—R9—R10—R11—R12—R13—R14—NH2, ??(I) as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: August 12, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Waleed Danho, George Ehrlich, David C Fry, Wajiha Khan, Joseph Swistok
  • Selective Linear Peptides with Melanocortin-4 Receptor (MC4-R) Agonist Activity
    Publication number: 20080177036
    Abstract: Peptides of formulae I, II and III that selectively activate melanocortin-4 (MC-4) receptor activity.
    Type: Application
    Filed: March 14, 2008
    Publication date: July 24, 2008
    Inventors: Li Chen, Adrian Wai-Hing Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Keith Alan Yagaloff
  • Neuropeptide-2 receptor (Y-2R) agonists and uses thereof
    Publication number: 20070135351
    Abstract: Provided herein are neuropeptide-2 receptor agonists of the formula (I): as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity and diabetes.
    Type: Application
    Filed: December 1, 2006
    Publication date: June 14, 2007
    Inventors: Karin Conde-Knape, Waleed Danho, George Ehrlich, Nader Fotouhi, David Fry, Wajiha Khan, Anish Konkar, Cristina Rondinone, Joseph Swistok, Rebecca Taub, Jefferson Tilley
  • Neuropeptide-2 receptor (Y-2R) agonists and uses thereof
    Publication number: 20060160742
    Abstract: Provided herein are neuropeptide-2 receptor agonists of the formula (I): Y—R1—R2—X—R3—R4—R5—R6—R7—R8—R9—R10—R11—R12—R13—R14—NH2??(I), as well as pharmaceutically acceptable salts, derivatives and fragments thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity.
    Type: Application
    Filed: January 10, 2006
    Publication date: July 20, 2006
    Inventors: Waleed Danho, George Ehrlich, David Fry, Wajiha Khan, Joseph Swistok
  • Selective cyclic peptides with melanocortin-4 receptor (MC4-R) agonist activity
    Patent number: 7045591
    Abstract: Peptides cyclized via disulfide or lactam bridges are disclosed. The peptides exhibit melanocortin-4 receptor agonist activity and are useful for treating obesity.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: May 16, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Adrian Wai-Hing Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Yao Wang, Keith Alan Yagaloff
  • Selective linear peptides with melanocortin-4 receptor (MC4-R) agonist activity
    Publication number: 20050239711
    Abstract: Peptides of formulae I, II and III that selectively activate melanocortin-4 (MC-4) receptor activity.
    Type: Application
    Filed: June 22, 2005
    Publication date: October 27, 2005
    Inventors: Li Chen, Adrian Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Keith Yagaloff
  • Selective linear peptides with melanocor tin-4 receptor (MC4-R) agonist activity
    Publication number: 20030229200
    Abstract: Peptides of formulae I, II and III that selectively activate melanocortin-4 (MC-4) receptor activity.
    Type: Application
    Filed: May 9, 2003
    Publication date: December 11, 2003
    Inventors: Li Chen, Adrian Wai-Hing Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Keith Alan Yagaloff
  • Selective linear peptides with melanocortin-4 receptor (MC4-R) agonist activity
    Patent number: 6600015
    Abstract: Peptides that selectively stimulate melanocortin-4 (MC-4) receptor activity are disclosed.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: July 29, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Adrian Wai-Hing Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Keith Alan Yagaloff
  • Selective cyclic peptides with melanocortin-4 receptor (MC4-R) agonist activity
    Publication number: 20020143141
    Abstract: Peptides cyclized via disulfide or lactam bridges having melanocortin-4 receptor (MC4-R) agonist activity useful for treatment of obesity.
    Type: Application
    Filed: August 27, 2001
    Publication date: October 3, 2002
    Inventors: Li Chen, Adrian Wai-Hing Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Yao Wang, Keith Alan Yagaloff
  • Selective linear peptides with melanocortin-4 receptor (MC4-R) agonist activity
    Publication number: 20010056179
    Abstract: Peptides of formulae I, II and III selectively activate melanocortin-4 (MC-4) receptor activity.
    Type: Application
    Filed: March 19, 2001
    Publication date: December 27, 2001
    Inventors: Li Chen, Adrian W. Cheung, Xin-Jie Chu, Waleed Danho, Joseph Swistok, Keith A. Yagaloff
  • Synthesis of VIP analog
    Patent number: 6316593
    Abstract: This invention relates to a novel process for the synthesis of vasoactive intestinal peptide analog Ac(1-31)-NH2 from four protected peptide fragments.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: November 13, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Robert Bolin, Waleed Danho, Arthur M. Felix
  • Synthesis of VIP analog
    Patent number: 6080837
    Abstract: This invention relates to a novel process for the synthesis of vasoactive intestinal peptide analog Ac(1-31)--NH.sub.2 from four protected peptide fragments.
    Type: Grant
    Filed: February 7, 1997
    Date of Patent: June 27, 2000
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Robert Bolin, Waleed Danho, Arthur M. Felix
  • Analogs of tyrosine sulfate or tyrosine phosphate containing peptides
    Patent number: 5508437
    Abstract: Analogs of Tyrosine Sulfate or Tyrosine Phosphate containing peptides, the novel intermediate compounds used in the preparation of these analogs, as well as a method for suppressing appetite in subjects by administering to the subject an effective amount of CCK analog wherein one or more of any Tyrosine Sulfate present is substituted with a radical of the invention.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: April 16, 1996
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Waleed Danho, Jefferson W. Tilley, Joseph Triscari, Rolf Wagner
  • Intermediates for analogs of tyrosine sulfate or tyrosine phosphate containing peptides
    Patent number: 5296608
    Abstract: Analogs of Tyrosine Sulfate or Tyrosine Phosphate containing peptides, the novel intermediate compounds used in the preparation of these analogs, as well as a method for suppressing appetite in subjects by administering to the subject an effective amount of CCK analog wherein one or more of any Tyrosine Sulfate present is substituted with a radical of the invention.
    Type: Grant
    Filed: April 9, 1992
    Date of Patent: March 22, 1994
    Assignee: Hoffman-La Roche Inc.
    Inventors: Waleed Danho, Jefferson W. Tilley, Joseph Triscari, Rolf Wagner
  • Analogs of tyrosine sulfate or tyrosine phosphate containing peptides
    Patent number: 5182263
    Abstract: Analogs of Tyrosine Sulfate or Tyrosine Phosphate containing peptides, the novel intermediate compounds used in the preparation of these analogs, as well as a method for suppressing appetite in subjects by administering to the subject an effective amount of CCK analog wherein one or more of any Tyrosine Sulfate present is substituted with a radical of the invention.
    Type: Grant
    Filed: July 18, 1991
    Date of Patent: January 26, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Waleed Danho, Jefferson W. Tilley, Joseph Triscari, Rolf Wagner
  • CCK analogs with appetite regulating activity
    Patent number: 5128448
    Abstract: The invention is directed to novel CCK analogs wherein Tryptophan and/or Phenylalamine are substituted with a radical which provides enhanced appetite suppressant activity to the peptide.
    Type: Grant
    Filed: January 10, 1990
    Date of Patent: July 7, 1992
    Assignee: Hoffman-La Roche Inc.
    Inventors: Waleed Danho, David J. Nelson, Gary L. Olson, Shian-Jan Shiuey, Jefferson W. Tilley, Rolf Wagner
  • Cholecystokinin analogs for controlling appetite
    Patent number: 5013722
    Abstract: Cholecystokinin analogs useful for suppressing food intake in mammals and humans.
    Type: Grant
    Filed: August 25, 1989
    Date of Patent: May 7, 1991
    Assignee: Hoffmann-LaRoche Inc.
    Inventors: Waleed Danho, Vincent S. Madison, Joseph Triscari
  • Method of peptide synthesis
    Patent number: 4965343
    Abstract: A method for the solid phase synthesis of multi-sulfated peptides comprising coupling side-chain unprotected hydroxyamino acids to the peptide chain utilizing benzotriazol-1-yl-oxy-tris (dimethyl)-phosphonium hexafluorophosphate (BOP) as a coupling reagent.
    Type: Grant
    Filed: January 28, 1988
    Date of Patent: October 23, 1990
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Arthur M. Felix, Alain Fournier, Waleed Danho
  • Cyclic peptides having appetite regulating activity
    Patent number: 4808701
    Abstract: Cyclic peptides with appetite regulating activity.
    Type: Grant
    Filed: March 30, 1987
    Date of Patent: February 28, 1989
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Waleed Danho, Joseph Triscari, Vincent S. Madison