Abstract: Disclosed is a manifold including a housing having multiple ports and multiple bores networking the ports. An actuatable valve, such as a slidable valve, including one or more bores may be positioned in the housing such that the valve is actuatable between a first position and a second position. Actuation of the valve may selectively establish a desired fluid pathway through the manifold. One or more seals may be interposed between the valve and the housing. The seal includes at least a first sealing element, a second sealing element, and a land extending between the sealing elements. The sealing elements are configured to provide a fluid tight seal between the housing and the valve when the valve is in either the first or second position, and the land is configured to provide a fluid tight seal between the housing and the valve when the valve is in an intermediate position.

Abstract: Systems and methods for improving medical fluid delivery systems, such as hemofiltration (“HF”) and hemodiafiltration (“HDF”) are provided. In first embodiments, systems and methods for selectively performing pre- and postdilution HF and HDF clearance modes is provided. In other embodiments, systems and methods for providing prime bolus and rinseback fluid volumes before, during and/or after HF and HDF therapies are provided. In further embodiments, improved systems and methods for removing ultrafiltrate from the patient are provided. Still further, improved filtration configurations and methods are provided.