Abstract: Precision digital chronography based on detected changes in state of a processor is described. The changes in state may be detected by another processor and an averaged time interval generated. A signal corresponding to the averaged time interval may be communicated to a distributed database and propagated to remote systems. Devices associated with the remote systems may adjust or set a device clock in accordance with the averaged time interval.

Abstract: The present invention provides methods comprising the in vivo delivery of small nucleic acid molecules capable of mediating RNA interference and reducing the expression of myostatin, wherein the small nucleic acid molecules are introduced to a subject by systemic administration. Specifically, the invention relates to methods comprising the in vivo delivery of short interfering nucleic acid (siNA) molecules that target a myostatin gene expressed by a subject, wherein the siNA molecule is conjugated to a lipophilic moiety, such as cholesterol. The myostatin siNA conjugates that are delivered as per the methods disclosed are useful to modulate the in vivo expression of myostatin, increase muscle mass and/or enhance muscle performance. Use of the disclosed methods is further indicated for treating musculoskeletal diseases or disorders and/or diseases or disorders that result in conditions in which muscle is adversely affected.

Abstract: The present invention provides methods comprising the in vivo delivery of small nucleic acid molecules capable of mediating RNA interference and reducing the expression of myostatin, wherein the small nucleic acid molecules are introduced to a subject by systemic administration. Specifically, the invention relates to methods comprising the in vivo delivery of short interfering nucleic acid (siNA) molecules that target a myostatin gene expressed by a subject, wherein the siNA molecule is conjugated to a lipophilic moiety, such as cholesterol. The myostatin siNA conjugates that are delivered as per the methods disclosed are useful to modulate the in vivo expression of myostatin, increase muscle mass and/or enhance muscle performance. Use of the disclosed methods is further indicated for treating musculoskeletal diseases or disorders and/or diseases or disorders that result in conditions in which muscle is adversely affected.

Abstract: The present invention provides methods comprising the in vivo delivery of small nucleic acid molecules capable of mediating RNA interference and reducing the expression of myostatin, wherein the small nucleic acid molecules are introduced to a subject by systemic administration. Specifically, the invention relates to methods comprising the in vivo delivery of short interfering nucleic acid (siNA) molecules that target a myostatin gene expressed by a subject, wherein the siNA molecule is conjugated to a lipophilic moiety, such as cholesterol. The myostatin siNA conjugates that are delivered as per the methods disclosed are useful to modulate the in vivo expression of myostatin, increase muscle mass and/or enhance muscle performance. Use of the disclosed methods is further indicated for treating musculoskeletal diseases or disorders and/or diseases or disorders that result in conditions in which muscle is adversely affected.

Abstract: The present invention provides methods comprising the in vivo delivery of small nucleic acid molecules capable of mediating RNA interference and reducing the expression of myostatin, wherein the small nucleic acid molecules are introduced to a subject by systemic administration. Specifically, the invention relates to methods comprising the in vivo delivery of short interfering nucleic acid (siNA) molecules that target a myostatin gene expressed by a subject, wherein the siNA molecule is conjugated to a lipophilic moiety, such as cholesterol. The myostatin siNA conjugates that are delivered as per the methods disclosed are useful to modulate the in vivo expression of myostatin, increase muscle mass and/or enhance muscle performance. Use of the disclosed methods is further indicated for treating musculoskeletal diseases or disorders and/or diseases or disorders that result in conditions in which muscle is adversely affected.

Abstract: The present invention provides methods comprising the in vivo delivery of small nucleic acid molecules capable of mediating RNA interference and reducing the expression of myostatin, wherein the small nucleic acid molecules are introduced to a subject by systemic administration. Specifically, the invention relates to methods comprising the in vivo delivery of short interfering nucleic acid (siNA) molecules that target a myostatin gene expressed by a subject, wherein the siNA molecule is conjugated to a lipophilic moiety, such as cholesterol. The myostatin siNA conjugates that are delivered as per the methods disclosed are useful to modulate the in vivo expression of myostatin, increase muscle mass and/or enhance muscle performance. Use of the disclosed methods is further indicated for treating musculoskeletal diseases or disorders and/or diseases or disorders that result in conditions in which muscle is adversely affected.

Abstract: The present invention provides methods comprising the in vivo delivery of small nucleic acid molecules capable of mediating RNA interference and reducing the expression of myostatin, wherein the small nucleic acid molecules are introduced to a subject by systemic administration. Specifically, the invention relates to methods comprising the in vivo delivery of short interfering nucleic acid (siNA) molecules that target a myostatin gene expressed by a subject, wherein the siNA molecule is conjugated to a lipophilic moiety, such as cholesterol. The myostatin siNA conjugates that are delivered as per the methods disclosed are useful to modulate the in vivo expression of myostatin, increase muscle mass and/or enhance muscle performance. Use of the disclosed methods is further indicated for treating musculoskeletal diseases or disorders and/or diseases or disorders that result in conditions in which muscle is adversely affected.

Abstract: Systems and methods for navigating a three-dimensional (3D) media guidance application are provided. A first selectable media guidance object may be displayed on a screen that when viewed through the stereoscopic optical device may appear in a first plane. A second selectable media guidance object may be displayed on the screen that when viewed through the stereoscopic optical device may appear in a second plane. The first and second planes may be perceived to intersect an axis normal to the display in different locations. A user selection of at least one of the first and second selectable media guidance objects may be received. An action of moving a cursor in 3D space or selecting one of the selectable media guidance objects displayed in the 3D space may be performed based on the user selection. The user selection may be performed with an input device having as accelerometer.

Abstract: An electronic device enabled with a Near Field Communications (“NFC”) reading capability may perform event-based asset tracking and/or order adherence, and/or rewards management in conjunction with a Software Service Platform. Assets may be provided with intelligent Radio Frequency Identification (“RFID”) tags in which such is associated with trackable event and such event may be associated with a master order of one or more such events. The electronic device may be programmable such that the various functions may be provided by application programs which may be preloaded on the electronic device as one or more client applications, provided to the NFC-enabled electronic device as a “software as a service” (“SaaS”) delivery, or provided to the NFC-enabled electronic device in any other desired manner.

Abstract: The present invention provides methods comprising the in vivo delivery of small nucleic acid molecules capable of mediating RNA interference and reducing the expression of myostatin, wherein the small nucleic acid molecules are introduced to a subject by systemic administration. Specifically, the invention relates to methods comprising the in vivo delivery of short interfering nucleic acid (siNA) molecules that target a myostatin gene expressed by a subject, wherein the siNA molecule is conjugated to a lipophilic moiety, such as cholesterol. The myostatin siNA conjugates that are delivered as per the methods disclosed are useful to modulate the in vivo expression of myostatin, increase muscle mass and/or enhance muscle performance. Use of the disclosed methods is further indicated for treating musculoskeletal diseases or disorders and/or diseases or disorders that result in conditions in which muscle is adversely affected.

Abstract: Described herein are methods and system for providing digital non-linear loop control. In one embodiment, system with digital non-linear loop control comprises a parameter control circuit configured to modify a signal based on a control signal, a processing circuit configured to process the signal, and a parameter measurement circuit configured to measure a parameter value of the signal. The system also comprises a digital non-linear control circuit configured to compare the measured parameter value with a desired parameter value, to determine a control signal value based on the comparison using a lookup table (LUT) that characterizes a non-linear control response of the system, and to output the control signal to the parameter control circuit based on the determined control signal value.

Abstract: Systems and methods for navigating a three-dimensional (3D) media guidance application are provided. A first selectable media guidance object may be displayed on a screen that when viewed through the stereoscopic optical device may appear in a first plane. A second selectable media guidance object may be displayed on the screen that then viewed through the stereoscopic optical device may appear in a second plane. The first and second planes may be perceived to intersect an axis normal to the display is different locations. A user selection of at least one of the first and second selectable media guidance objects may be received. An action of moving a cursor in 3D space or selecting one of the selectable media guidance objects displayed in the 3D space may be performed based on the user selection. The user selection may be performed with an input device having as accelerometer.

Abstract: In certain embodiments, a method for manufacturing an integral duplex bearing having an outer ring, a first inner ring, and a second inner ring includes forming a first outer raceway and a second outer raceway in an inner surface of the outer ring. The method further includes forming a first inner raceway in an outer surface of the first inner ring and a second inner raceway in an outer surface of the second inner ring while the first inner ring and the second inner ring are joined together. The first and second inner rings each have an outer surface diameter less than an inner surface diameter of the outer ring such that the first and second inner rings may be positioned inside the outer ring with the first inner raceway located adjacent to the first outer raceway and the second inner raceway located adjacent to the second outer raceway. The method further includes separating the first inner ring from the second inner ring.

Abstract: Systems and methods for navigating a three-dimensional (3D) media guidance application are provided. A first selectable media guidance object may be displayed on a screen that when viewed through the stereoscopic optical device may appear in a first plane. A second selectable media guidance object may be displayed on the screen that when viewed through the stereoscopic optical device may appear in a second plane. The first and second planes may be perceived to intersect an axis normal to the display in different locations. A user selection of at least one of the first and second selectable media guidance objects may be received. An action of moving a cursor in 3D space or selecting one of the selectable media guidance objects displayed in the 3D space may be performed based on the user selection. The user selection may be performed with an input device having an accelerometer.

Abstract: Method and systems for operating a media equipment device having at least a full-power mode and an off-power mode are provided. A voltage supply to the media equipment device may be controlled by the media equipment device itself or by an external power management unit to automatically power-off the media equipment device, and power the device back on a future time. Prior to powering off the media equipment device, a portion of program schedule information stored in the volatile memory of the media equipment device may be mirrored to nonvolatile memory and may be restored on a priority basis after the media equipment device is powered back up. An external power management unit for controlling the media equipment device may also automatically detect and identify devices in the home based on a power signature of the device and manage the operation of the device based on the identification.

Abstract: Method and systems for operating a media equipment device having at least a full-power mode and an off-power mode are provided. A voltage supply to the media equipment device may be controlled by the media equipment device itself or by an external power management unit to automatically power-off the media equipment device, and power the device back on a future time. Prior to powering off the media equipment device, a portion of program schedule information stored in the volatile memory of the media equipment device may be mirrored to nonvolatile memory and may be restored on a priority basis after the media equipment device is powered back up. An external power management unit for controlling the media equipment device may also automatically detect and identify devices in the home based on a power signature of the device and manage the operation of the device based on the identification.

Abstract: A fitted bed sheet capable of fitting mattresses of multiple lengths is disclosed. The fitted bed sheet has a first section constructed primarily of non-stretch material and a second section sewn to the foot of the first section that is constructed primarily of non-elastic stretch material. The second section stretches to accommodate mattresses of longer lengths thereby eliminating the need to maintain multiple fitted bed sheets. The present invention increases user comfort, can be processed in commercial laundries, reduces the labor of making the bed, is easier to fold, and has a longer useful life than fitted sheets constructed with elastic stretch material. The fitted bed sheet can be washed, ironed, and folded automatically. The present invention may be used in institutional or private settings.

Abstract: A fitted bed sheet capable of fitting mattresses of multiple lengths is disclosed. The fitted bed sheet has a first section constructed primarily of non-stretch material and a second section sewn to the foot of the first section that is constructed primarily of non-elastic stretch material. The second section stretches to accommodate mattresses of longer lengths thereby eliminating the need to maintain multiple fitted bed sheets. The present invention increases user comfort, can be processed in commercial laundries, reduces the labor of making the bed, is easier to fold, and has a longer useful life than fitted sheets constructed with elastic stretch material. The fitted bed sheet can be washed, ironed, and folded automatically. The present invention may be used in institutional or private settings.

Abstract: An electronic device enabled with a Near Field Communications (“NFC”) reading capability may perform event-based asset tracking and/or order adherence, and/or rewards management in conjunction with a Software Service Platform. Assets may be provided with intelligent Radio Frequency Identification (“RFID”) tags in which such is associated with trackable event and such event may be associated with a master order of one or more such events. The electronic device may be programmable such that the various functions may be provided by application programs which may be preloaded on the electronic device as one or more client applications, provided to the NFC-enabled electronic device as a “software as a service” (“SaaS”) delivery, or provided to the NFC-enabled electronic device in any other desired manner.

Abstract: In certain embodiments, a method for manufacturing an integral duplex bearing having an outer ring, a first inner ring, and a second inner ring includes forming a first outer raceway and a second outer raceway in an inner surface of the outer ring. The method further includes forming a first inner raceway in an outer surface of the first inner ring and a second inner raceway in an outer surface of the second inner ring while the first inner ring and the second inner ring are joined together. The first and second inner rings each have an outer surface diameter less than an inner surface diameter of the outer ring such that the first and second inner rings may be positioned inside the outer ring with the first inner raceway located adjacent to the first outer raceway and the second inner raceway located adjacent to the second outer raceway. The method further includes separating the first inner ring from the second inner ring.