Abstract: A method and system for treating brain disorders comprises detecting activity of a first target area of the brain via a first implanted sensor and determining the presence of target brain activity by analyzing the detected brain activity in combination with treating the user based upon the determined presence of target brain activity by supplying a first therapeutic agent to the first target area via a first implanted fluid delivery member including at least one distal opening adjacent to the first target area. In addition, the system may be used as well for testing the effectiveness of drugs.

Abstract: An adjustable optical mount adapted for use with an optical table defining a reference plane includes a hollow housing with openings in the side walls to allow passage of an optical beam therethrough, a gimbal base fixed on the top of the housing, a gimbal plate adjustably mounted under the gimbal base, and a carrier bracket fixed to the gimbal plate for holding preselected optical elements within the housing along the path of the beam. Adjustment mechanisms are provided to tilt and rotate the gimbal plate so as to align the optical element on a selected axis relative to the reference plane.

Abstract: An adjustable optical mount adapted for use with an optical table defining a reference plane includes a hollow housing with openings in the side walls to allow passage of an optical beam therethrough, a gimbal base fixed on the top of the housing, a gimbal plate adjustably mounted under the gimbal base, and a carrier bracket fixed to the gimbal plate for holding preselected optical elements within the housing along the path of the beam. Adjustment mechanisms are provided to tilt and rotate the gimbal plate so as to align the optical element on a selected axis relative to the reference plane.

Abstract: Apparatus and methods in which very small volumes of biological fluid-borne material, particularly large molecules such as proteins, may be selectively extracted from or delivered to interstitial fluid (in vivo or in vitro) by means of intra-parenchymal micro-probes inserted in the brain. The primary use of the micro-probe is in neuroscience research, clinical diagnostics or treatment of epilepsy and other neurological conditions; it may also be applied to other organs and biological systems. Eventual human clinical applications may include neurosurgical monitoring, functional tracking of devices or materials introduced in a surgical procedure, or cerebro-spinal fluid sampling.

Abstract: Apparatus and methods in which very small volumes of material may be extracted, delivered, interrogated or stimulated via optical, electromagnetic or mechanical means, in vivo or in vitro, for site-specific detection, characterization, stimulation, diagnostics or therapy, comprising optical, fluidic, chemical, electromagnetic and biological techniques applied via a microprobe in a single intra-parenchymal tissue perforation procedure in the brain. The primary use of the device is in neuroscience research, clinical diagnostics and therapeutics applications in the brain, however, the device may also be beneficially applied to other organs and biological systems. Human clinical applications may include neurosurgical intra-operative monitoring, extra-operative chronic monitoring of devices introduced in an operation, and diagnostic monitoring combined with simultaneous neuroimaging.

Abstract: A method and system for treating brain disorders comprises detecting activity of a first target area of the brain via a first implanted sensor and determining the presence of target brain activity by analyzing the detected brain activity in combination with treating the user based upon the determined presence of target brain activity by supplying a first therapeutic agent to the first target area via a first implanted fluid delivery member including at least one distal opening adjacent to the first target area. In addition, the system may be used as well for testing the effectiveness of drugs.

Abstract: Methods, for use with a laser ablation or drilling process, which achieve depth-controlled removal of composite-layered work-piece material by real-time feedback of ablation plasma spectral features. The methods employ the use of electric, magnetic or combined fields in the region of the laser ablation plume to direct the ablated material. Specifically, the electric, magnetic or combined fields cause the ablated material to be widely dispersed, concentrated in a target region, or accelerated along a selected axis for optical or physical sampling, analysis and laser feedback control. The methods may be used with any laser drilling, welding or marking process and are particularly applicable to laser micro-machining. The described methods may be effectively used with ferrous and non-ferrous metals and non-metallic work-pieces. The two primary benefits of these methods are the ability to drill or ablate to a controlled depth, and to provide controlled removal of ablation debris from the ablation site.

Abstract: A calibration device is disclosed for use with fluorescence photometers of the type which direct an excitation radiation at a sample to be tested, and then read the fluorescent emission from the sample to identify bacterial growth in the sample. In the past the emission reading accuracy of fluorescence photometers has been tested by passive standards. The known standards have some shortcomings, in that they may have varying characteristics with time and temperature, and further because they are difficult to manufacture without experiencing some variation between the standards. The present invention addresses the problem by generating a particular fluorescent emission and directing that emission towards a photometer to be tested. Since the emission which is directed outwardly of the calibration device is predetermined and known, this directed radiation can be compared to that which is read by the fluorescence photometer. In this way, a positive evaluation of the reading accuracy of the photometer can be made.

Abstract: The detection of bacterial growth or the performance of other interrogative processes in multiple sample vials is accomplished using a moving rack that selectively couples optical locations to an optical excitation and detection system. The apparatus includes a drive mechanism combining agitation of the culture vials with a sequential scanning of an array of optical fibers, preferably by a spectrophotometric excitation and detection system. Selection of each culture vial provides, for example, optical detection of bacterial growth by fluorescence or other spectrophotometric measurements. A rack for holding vials is preferably the only moving assembly, and requires no mechanical or electrical interconnection with the excitation and detection system for its operation.