Patents by Inventor Walter G. Gowan, Jr.
Walter G. Gowan, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150165029Abstract: The present invention provides oral formulations of poorly bioavailable and/or poorly absorbable, and/or poorly water soluble therapeutic agents. The invention features harmaceutical composition including a biopolymer, a therapeutic agent, for example an antimicrobial agent such as ceftriaxone, and an absorption enhancer, for example a polyoxyethylene alkyl ether absorption enhancer. Methods of making and using the pharmaceutical compositions is also described.Type: ApplicationFiled: January 8, 2015Publication date: June 18, 2015Inventors: Walter G. Gowan, JR., Dennis D. Keith, Sandra O'Connor
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Patent number: 8968781Abstract: The present invention provides oral formulations of poorly bioavailable and/or poorly absorbable, and/or poorly water soluble therapeutic agents. The invention features pharmaceutical composition including a biopolymer, a therapeutic agent, for example an antimicrobial agent such as ceftriaxone, and an absorption enhancer, for example a polyoxyethylene alkyl ether absorption enhancer. Methods of making and using the pharmaceutical compositions is also described.Type: GrantFiled: April 27, 2006Date of Patent: March 3, 2015Assignee: Cubist Pharmaceuticals, Inc.Inventors: Walter G. Gowan, Jr., Dennis D. Keith, Sandra O'Connor
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Patent number: 8580256Abstract: The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.Type: GrantFiled: June 23, 2010Date of Patent: November 12, 2013Assignee: Yeda Reseach and Development Company LimitedInventors: Shlomo Dagan, Rachel Eren, Hemant Kumar Misra, Walter G. Gowan, Jr., Sandra O'Connor
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Publication number: 20100330099Abstract: The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.Type: ApplicationFiled: June 23, 2010Publication date: December 30, 2010Applicant: YEDA RESEARCH AND DEVELOPMENT COMPANY LIMITEDInventors: Shlomo Dagan, Rachel Eren, Hemant Kumar Misra, Walter G. Gowan, JR., Sandra O'Connor
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Patent number: 7785595Abstract: The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.Type: GrantFiled: April 18, 2005Date of Patent: August 31, 2010Assignee: Yeda Research and Development Company LimitedInventors: Shlomo Dagan, Rachel Eren, Hemant Kumar Misra, Walter G. Gowan, Jr., Sandra O'Connor
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Patent number: 7785650Abstract: Water soluble, gelatin-free dip coatings for pharmaceutical solid dosage forms such as tablets comprising HPMC and xanthan gum, carrageenan, and mixtures thereof, or HPMC and castor oil or maltodextrin.Type: GrantFiled: June 27, 2007Date of Patent: August 31, 2010Assignee: McNeil-PPC, Inc.Inventors: Cynthia Gulian, Walter G. Gowan, Jr., Kishor B. Parekh, Joseph M. Morris, Thomas J. Markley, Dennis C. Wieand, Gerard P. McNally, Christopher Szymczak
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Publication number: 20090092739Abstract: Water soluble, gelatin-free dip coatings for tablets and capsules comprising sucrose, glycerin and pre-gelatinized starch and/or tapioca dextrin or comprising hydroxypropyl starch, thickener, and plasticizer.Type: ApplicationFiled: December 15, 2008Publication date: April 9, 2009Inventors: Cynthia GULIAN, Walter G. Gowan, JR., Christopher Szymczak, Michelle Papalini, Jen-Chi Chen, Frank J. Bunick
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Publication number: 20080213366Abstract: The present invention provides oral formulations of poorly bioavailable and/or poorly absorbable, and/or poorly water soluble therapeutic agents. The invention features pharmaceutical composition including a biopolymer, a therapeutic agent, for example an antimicrobial agent such as ceftriaxone, and an absorption enhancer, for example a polyoxyethylene alkyl ether absorption enhancer. Methods of making and using the pharmaceutical compositions is also described.Type: ApplicationFiled: April 27, 2006Publication date: September 4, 2008Applicant: Cubist Pharmaceuticals, IncInventors: Walter G. Gowan Jr, Dennis D. Keith, Sandra O'Connor
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Patent number: 6090401Abstract: The present invention provides a quick dissolving, readily broken substrate suitable for the addition of pharmaceutical agents for oral administration. A method for making the substrate is also disclosed.Type: GrantFiled: March 31, 1999Date of Patent: July 18, 2000Assignee: McNeil-PPC, Inc.Inventors: Walter G. Gowan, Jr., Richard D. Fegley, Daniel McTeigue, Thomas E. Sox
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Patent number: 5876759Abstract: The present invention relates to a compressed pharmaceutical dosage form containing pharmaceutical particles coated with a taste-masking composition, a water-disintegratable, compressible carbohydrate and a binder. These components are dry blended and compressed into a dosage form, such as a tablet, having a hardness sufficient to cause the carbohydrate to disintegrate within 30 seconds after oral administration, thereby allowing the coated particles to be swallowed.Type: GrantFiled: April 16, 1997Date of Patent: March 2, 1999Assignee: McNeil-PPC, Inc.Inventor: Walter G. Gowan, Jr.
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Patent number: 5621005Abstract: The present invention relates to an aqueous pharmaceutical suspension composition comprising: from about 0.2% to 20% of a substantially water insoluble pharmaceutical active, e.g. ibuprofen; a suspension stabilizing effective amount of xanthan gum, pregelatinized starch and polyoxyethylene sorbitan monooleate; an effective amount of taste masking composition; and water, as well as a process for producing such aqueous pharmaceutical suspensions.Type: GrantFiled: September 28, 1994Date of Patent: April 15, 1997Assignee: McNeil-PPC, Inc.Inventor: Walter G. Gowan, Jr.
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Patent number: 5405617Abstract: A physicochemically stable pharmaceutical matrix composition is provided comprising: a pharmaceutical active and a water insoluble aliphatic or fatty acid ester, preferably stearyl stearate; a taste mask carrier for pharmaceutical actives comprising a taste masking effective amount of an aliphatic or fatty acid ester; and a method for preparing a pharmaceutical matrix without the use of organic and/or volatile solvents comprising the steps of: melting an aliphatic or fatty acid ester; admixing at least one pharmaceutical active with the molten aliphatic or fatty acid ester; and solidifying the admixture to produce a pharmaceutical matrix composition. The matrix is composed of an aliphatic, or fatty acid, ester that has a low melting point (50.degree.-100.degree. C.) and the melt exhibits: low viscosity, recongeals rapidly when cooled, does not exhibit polymorphism, and has good mold release properties.Type: GrantFiled: November 7, 1991Date of Patent: April 11, 1995Assignee: McNeil-PPC, Inc.Inventors: Walter G. Gowan, Jr., Richard D. Bruce
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Patent number: 5374659Abstract: The present invention relates to an aqueous pharmaceutical suspension composition comprising: from about 0.2% to 20% of a substantially water insoluble pharmaceutical active, e.g. ibuprofen; a suspension stabilizing effective amount of xanthan gum, pregelatinized starch and polyoxyethylene sorbitan monooleate; an effective amount of taste masking composition; and water, as well as a process for producing such aqueous pharmaceutical suspensions.Type: GrantFiled: March 28, 1994Date of Patent: December 20, 1994Assignee: McNeil-PPC, Inc.Inventor: Walter G. Gowan, Jr.