Patents by Inventor Walter Märki

Walter Märki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of thrombin inhibitors
    Patent number: 6410272
    Abstract: A method for the production and secretion of proteins with hirudin activity in an eukaryotic host organism is provided. There are also provided hybrid vectors comprising a DNA sequence encoding a signal peptide upstream of and in reading frame with the structural gene for desulphatohirudin, and eukaryotic host organisms transformed with said hybrid vectors.
    Type: Grant
    Filed: February 27, 1990
    Date of Patent: June 25, 2002
    Assignee: Ciba-Geigy Corporation a Corp. of New York
    Inventors: Bernd Meyhack, Walter Märki, Jutta Heim
  • Process for preparing recombinant eglin, protease inhibitor
    Patent number: 6342373
    Abstract: The invention relates to DNA sequences which code an eglin, expression plasmids containing such DNA sequences, hosts transformed with such expression plasmids, novel eglin compounds produced from such transformed hosts, monoclonal antibodies against eglins, hybridoma cells which produce such antibodies, and test kits for immunoassays containing such antibodies, and furthermore the processes for their preparation and a process for the preparation of eglins with the aid of the transformed hosts. The eglins which can be prepared according to the invention have useful pharmacological properties.
    Type: Grant
    Filed: May 24, 1991
    Date of Patent: January 29, 2002
    Assignee: UCP GEN-Pharma AG
    Inventors: Hans Rink, Manfred Liersch, Peter Sieber, Werner Rittel, Francois Meyer, Ursula Seemüller, Hans Fritz, Walter Märki, Sefik Alkan