Patents by Inventor Walter Martin Holleran

Walter Martin Holleran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for stimulating tissue growth and epithelial moisturization
    Patent number: 6399580
    Abstract: The invention herein encompasses methods effective to stimulate epithelial cell proliferation and/or enhance epithelial moisturization and lubrication in a mammalian subject utilizing a composition comprising one or more inhibitors of &bgr;-glucosidase activity or &bgr;-glucocerebrosidase activity. The composition of the method may alternatively comprise a glycosphingolipid, particularly glucocerebroside, or a combination of the above inhibitor(s) and a glycosphingolipid. The method is effective to enhance the cosmetic appearance of skin and promote healing of skin and mucous membranes damaged or deficient from aging, traumatic wounds, photo-aging and a variety of atrophic conditions. The method may be applied to cells in culture. Also included in the invention is a composition comprising one or more inhibitors of &bgr;-glucosidase and a glycosphingolipid useful to stimulate cell proliferation and enhance tissue moisturization and lubrication.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: June 4, 2002
    Assignee: The Regents of the University of California
    Inventors: Peter Michael Elias, Walter Martin Holleran
  • Methods and compositions for stimulating tissue growth and epithelial moisturization
    Patent number: 6395709
    Abstract: The invention herein encompasses methods effective to stimulate epithelial cell proliferation and/or enhance epithelial moisturization and lubrication in a mammalian subject utilizing a composition comprising one or more inhibitors of &bgr;-glucosidase activity or &bgr;-glucocerebrosidase activity. The composition of the method may alternatively comprise a glycosphingolipid, particularly glucocerebroside, or a combination of the above inhibitor(s) and a glycosphingolipid. The method is effective to enhance the cosmetic appearance of skin and promote healing of skin and mucous membranes damaged or deficient from aging, traumatic wounds, photo-aging and a variety of atrophic conditions. The method may be applied to cells in culture. Also included in the invention is a composition comprising one or more inhibitors of &bgr;-glucosidase and a glycosphingolipid useful to stimulate cell proliferation and enhance tissue moisturization and lubrication.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: May 28, 2002
    Assignee: The Regents of the University of California
    Inventors: Peter Michael Elias, Walter Martin Holleran
  • Methods and compositions for stimulating tissue growth and epithelial moisturization
    Patent number: 6054433
    Abstract: The invention herein encompasses methods effective to stimulate epithelial cell proliferation and/or enhance epithelial moisturization and lubrication in a mammalian subject utilizing a composition comprising one or more inhibitors of .beta.-glucosidase activity or .beta.-glucocerebrosidase activity. The composition of the method may alternatively comprise a glycosphingolipid, particularly glucocerebroside, or a combination of the above inhibitor(s) and a glycosphingolipid. The method is effective to enhance the cosmetic appearance of skin and promote healing of skin and mucous membranes damaged or deficient from aging, traumatic wounds, photo-aging and a variety of atrophic conditions.The method may be applied to cells in culture. Also included in the invention is a composition comprising one or more inhibitors of .beta.-glucosidase and a glycosphingolipid useful to stimulate cell proliferation and enhance tissue moisturization and lubrication.
    Type: Grant
    Filed: November 3, 1994
    Date of Patent: April 25, 2000
    Assignee: The Regents of the University of California
    Inventors: Peter Michael Elias, Walter Martin Holleran