Abstract: Disclosed are conjugates including a recognition element covalently bonded to or linked through a linker to a payload. The payload is a pharmaceutical agent (e.g., an antineoplastic agent, anti-infective agent, or anti-inflammatory agent) or a diagnostic agent. Also disclosed are methods of using the conjugates.

Abstract: The present disclosure relates to compounds of formulas (A) and (I), pharmaceutically acceptable salts thereof, and solvates of any of the foregoing, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in particular cancer, such as colorectal cancer, using the same.

Abstract: N-(3-Substituted thiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamides and N-(3-substituted oxazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamides are disclosed. The compounds activate Yap and inhibit Lats kinases. They are therefore useful for treating hearing loss.

Abstract: A container for animals or objects in a liquid is disclosed. The container comprises a cylinder capped by two removable lids and a floating basket. When one of the lids is removed, the liquid may be drained and refreshed without either the basket or the contained animals or objects falling out. When the other lid is removed, the basket floats above the liquid and carries the animals or objects out of the liquid where they can be easily removed by a user. The container is useful to anglers who use live minnows as bait, but may be useful in several other applications. The instant abstract is neither intended to define the invention disclosed in this specification nor intended to limit the scope of the invention in any way.

Abstract: Disclosed are conjugates including a recognition element covalently bonded to or linked through a linker to a payload. The payload is a pharmaceutical agent (e.g., an antineoplastic agent, anti-infective agent, or anti-inflammatory agent) or a diagnostic agent. Also disclosed are methods of using the conjugates.

Abstract: A container for animals or objects in a liquid is disclosed. The container comprises a cylinder capped by two removable lids and a floating basket. When one of the lids is removed, the liquid may be drained and refreshed without either the basket or the contained animals or objects falling out. When the other lid is removed, the basket floats above the liquid and carries the animals or objects out of the liquid where they can be easily removed by a user. The container is useful to anglers who use live minnows as bait, but may be useful in several other applications.

Abstract: A container for animals or objects in a liquid is disclosed. The container comprises a cylinder capped by two removable lids and a floating basket. When one of the lids is removed, the liquid may be drained and refreshed without either the basket or the contained animals or objects falling out. When the other lid is removed, the basket floats above the liquid and carries the animals or objects out of the liquid where they can be easily removed by a user. The container is useful to anglers who use live minnows as bait, but may be useful in several other applications.

Abstract: An improved fire extinguishing system for residential and commercial cook stoves and ranges includes one or more heat and/or smoke sensors connected to a control circuit. A cut-off switch activated by the heat and/or smoke sensors is provided to interrupt the flow of gas or electric power to the cook stove burners. The burners are in fluid communication with a source of a fire suppressant. Upon sensing a fire on the cook stove, fluid communication is established between the burners and fire suppressant for rapidly cooling the burners and extinguishing the fire.

Abstract: A waveform output apparatus comprises a circuit including a capacitor, resistors, and amplifiers, an LED and a coil connected to a power supply. The circuit is housed in a portable housing. When energized, the apparatus outputs waveforms that modulate EMF and ELF signals that may be absorbed by the human body.

Abstract: The present invention relates to an assembly for electrically connecting two cables together. More particularly, the invention provides an upper and lower housing with a conductive commoning contact slidably positioned in the lower housing and adapted to pierce through the insulation of the two cables and make electrical contact with the conductive strands within.

Abstract: The present invention discloses a device for connecting two flat insulated wires. The device includes a body member having an opening therethrough and a wedge member. The sides of the opening have a sharp ridge so that as the wedge squeezes the wires against the sides, the teeth pierce the insulation to make electrical contact.