Patents by Inventor Walter Rittersdorf
Walter Rittersdorf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6214570Abstract: The subject matter of the application is a method for the separation of non-HDL lipoproteins from biological fluids in a carrier through which liquids can flow. The carrier contains a precipitating agent for non-high density lipoproteins (non-HDLs).Type: GrantFiled: July 14, 1998Date of Patent: April 10, 2001Assignee: Roche Diagnostics GmbHInventors: Walter Rittersdorf, Ulfert Deneke, Gerhard Hiller, Hartmut Merdes, Klaus Buecker, Uwe Goebbert
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Patent number: 6171849Abstract: An apparatus comprising a first porous carrier and a second porous carrier for evaluating biological fluid samples is disclosed. The apparatus is used for separating non high density lipoprotein (non-HDL) from a lipoprotein in a body sample and for determining high density lipoprotein (HDL) cholesterol in a HDL and non high density lipoprotein (non-HDL) in a body sample.Type: GrantFiled: January 12, 2000Date of Patent: January 9, 2001Assignee: Roche Diagnostics GmbHInventors: Walter Rittersdorf, Ulfert Deneke, Gerhard Hiller, Hartmut Merdes, Klaus Buecker, Uwe Goebbert
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Patent number: 5786164Abstract: The invention relates to a method useful in separating non-high density lipoproteins, referred to as "non-HDLs", from biological fluids containing them. A porous carrier is provided which contains a non-HDL precipitating agent. One need only contact the sample of interest to the carrier for one minute or less, after which the precipitated non-HDL-s are no longer present in the sample being tested. The applications of the method include the ability to determine high density lipoproteins in the sample without interference from non-HDLs.Type: GrantFiled: June 11, 1996Date of Patent: July 28, 1998Assignee: Boehringer Mannheim GmbHInventors: Walter Rittersdorf, Ulfert Deneke, Gerhard Hiller, Hartmut Merdes, Klaus Buecker, Uwe Goebbert
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Patent number: 5580743Abstract: The invention relates to a method useful in separating non-high density lipoproteins, referred to as "non-HDLs", from biological fluids containing them. A porous carrier is provided which contains a non-HDL precipitating agent. One need only contact the sample of interest to the carrier for one minute or less, after which the precipitated non-HDLs are no longer present in the sample being tested. The applications of the method include the ability to determine high density lipoproteins in the sample without interference from non-HDLs.Type: GrantFiled: February 6, 1995Date of Patent: December 3, 1996Assignee: Boehringer Mannheim GmbHInventors: Walter Rittersdorf, Ulfert Deneke, Gerhard Hiller, Hartmut Merdes, Klaus Buecker, Uwe Goebbert
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Patent number: 5426030Abstract: The invention relates to an apparatus and a method useful in separating non-high density lipoproteins, referred to as "non-HDLs", from biological fluids containing them. A porous carrier is provided which contains a non-HDL precipitating agent. One need only contact the sample of interest to the carrier for one minute or less, after which the precipitated non-HDLs are no longer present in the sample being tested. The applications of the method include the ability to determine high density lipoproteins in the sample without interference from non-HDLs.Type: GrantFiled: August 24, 1990Date of Patent: June 20, 1995Assignee: Boehringer Mannheim GmbHInventors: Walter Rittersdorf, Ulfert Deneke, Gerhard Hiller, Hartmut Merdes, Klaus Buecker, Uwe Goebbert
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Patent number: 5215924Abstract: The invention relates to a method for determining an ion in an aqueous sample. The method involves contacting the sample with a water immiscible material including an ionophore, a pH indicator and a compound which stabilizes sensitivity of the assay. The ion reacts with the ionophore in the water immiscible material, releasing a proton which reacts with the pH indicator generating a color change which is representative of the ion to be measured. The stabilizing compound stabilizes this change. Also described are compositions including the three recited elements, and various new compounds useful as the stabilizer.Type: GrantFiled: May 10, 1991Date of Patent: June 1, 1993Assignee: Boehringer Mannheim GmbHInventors: Walter Rittersdorf, Werner Guethlein, Detlef Thym, Peter Vogel
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Patent number: 5194389Abstract: The subject matter of the present invention are naphthol derivatives having the general formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 are the same or different and each represents hydrogen, an alkyl or alkoxy group, in which at least one of the residues is a (C.sub.8 -C.sub.30)-alkyl or alkoxy residueR.sup.4 is hydrogen or an alkyl groupR.sup.5 is a nitro group, an alkyl group substituted by halogen, a cyano group, a sulfonamide group or an alkylsulfonyl groupX is nitrogen or the residue CR.sup.6 andY is sulphur or the residue CR.sup.7 =CR.sup.8in which R.sup.6, R.sup.7, R.sup.8 are the same or different and each denotes hydrogen, halogen, a nitro group, a cyano group, an alkyl or an alkyl group substituted by halogen or an alkylsulfonyl group, a process for their production and their use as a pH indicator or in methods and agents for the determination of an ion in an aqueous liquid.Type: GrantFiled: May 10, 1991Date of Patent: March 16, 1993Assignee: Boehringer Mannheim GmbHInventors: Walter Rittersdorf, Werner Guethlein, Peter Vogel, Detlef Thym
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Patent number: 5055195Abstract: The present invention provides erythrocyte-retention substrates of the general formula:R.sub.1 --Sp--R.sub.2in which Sp is a bridge serving as a spacer, R.sub.1 is a strongly polar group and R.sub.2 is also a strongly polar group or, when Sp is an electron-conductive group, R.sub.2 can also be a polarizable group.The present invention also provides a process for the separation of erythrocytes from whole blood, wherein whole blood is brought into contact with one of the above substrates and subsequently filtered through a filter layer and the separated plasma obtained.Type: GrantFiled: July 20, 1987Date of Patent: October 8, 1991Assignee: Boehringer Mannheim GMBHInventors: Heinz-Friedrich Trasch, Erwin Endres, Andreas Trost, Walter Rittersdorf
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Patent number: 4957872Abstract: The present invention provides a process for the detection of redox reactions by introducing a redox reagent system into a test system, wherein a soluble iodate is additionally added to the test system in an amount which is in excess of the highest amount of disturbing reducing agents present in the test system.The present invention also provides a diagnostic agent for the detection of redox reactions containing a redox reagent system, wherein the test system used additionally contains an iodate which is soluble therein in an amount which is in excess of the highest amount of disturbing reducing agents present in the test system.Type: GrantFiled: January 20, 1988Date of Patent: September 18, 1990Assignee: Boehringer Mannheim GmbHInventors: Laszlo Koever, Walter Rittersdorf, Wolfgang Werner
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Patent number: 4749648Abstract: Esters and agents including the esters, useful as substrates for esterolytic and/or proteolytic enzymes, said esters being compounds of the general formula: ##STR1## in which R".sub.1, R".sub.2, R".sub.3 and R".sub.4, which may be the same or different, are hydrogen atoms or lower alkyl, lower alkoxy, alkylamino or dialkylamino radicals or in which two adjacent substituents can also represent a fused benzene ring, A is a residue of an amino acid or of a peptide and B is a nitrogen protective group conventional in peptide chemistry or derived therefrom and the method of preparation and use.Type: GrantFiled: May 4, 1984Date of Patent: June 7, 1988Assignee: Boehringer Mannheim GmbHInventors: Dieter Berger, Gunter Frey, Wolfgang-Reinhold Knappe, Manfred Kuhr, Walter Rittersdorf, Wolfgang Werner
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Method for the determination of redox reactions using iodate to eliminate ascorbic acid interference
Patent number: 4743559Abstract: The present invention provides a process for the detection of redox reactions by introducing a redox reagent system into a test system, wherein a soluble iodate is additionally added to the test system in an amount which is in excess of the highest amount of disturbing reducing agents present in the test system.The present invention also provides a diagnostic agent for the detection of redox reactions containing a redox reagent system, wherein the test system used additionally contains an iodate which is soluble therein in an amount which is in excess of the highest amount of disturbing reducing agents present in the test system.Type: GrantFiled: December 15, 1986Date of Patent: May 10, 1988Assignee: Boehringer Mannheim GmbHInventors: Laszlo Koever, Walter Rittersdorf, Wolfgang Werner -
Patent number: 4603107Abstract: The present invention provides a process for the kinetic determination of .gamma.-glutamyl transferase activity by the reaction of a .gamma.-glutamylarylamide with the formation of an arylamine at a pH value of from 6 to 10, wherein the arylamine is simultaneously reacted with an aromatic amine or phenol appropriate as a coupling component and an appropriate oxidation agent to give a colored compound with an absorption maximum above 565 nm, the rate of formation of which is monitored photometrically and is used as a measure for the .gamma.-glutamyl transferase activity.The present invention also provides a reagent for the kinetic determination of .gamma.-GT activity, wherein it contains the following reagents:.gamma.-GT-arylamide:1-100 mmol/l..gamma.-glutamyl acceptor (glycylglycine):10-500 mmol/l.coupling component:1-500 mmol/l.oxidation agent:0.1-500 mmol/l.buffer:10-1000 mmol/l.Type: GrantFiled: September 16, 1983Date of Patent: July 29, 1986Assignee: Boehringer Mannheim GmbHInventors: Ulfert Deneke, Rolf Nagel, Walter Rittersdorf
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Patent number: 4582684Abstract: A cuvette for the determination of a chemical component of a fluid by photo evaluation has two planar-shaped parts parallel to one another at least one of which is transparent in the spectral range used for the evaluation. A planar distance piece of a filamentary reticulation for receiving the fluid therein spaces the planar-shaped parts apart to set the length of the light path through the cuvette for the photo evaluation.Type: GrantFiled: September 12, 1983Date of Patent: April 15, 1986Assignee: Boehringer Mannheim GmbHInventors: Peter Vogel, Walter Rittersdorf
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Patent number: 4563422Abstract: The present invention provides a process for removing ascorbic acid from aqueous solutions by the addition of ascorbate oxidase, wherein catalase and hydrogen peroxide are also added to the solution.The present invention also provides an agent for the removal of ascorbic acid from aqueous solutions, based on a solid carrier material impregnated with ascorbate oxidase, wherein the carrier material also contains catalase and hydrogen peroxide and optionally also a stabilizer and/or buffer substance.Type: GrantFiled: May 21, 1982Date of Patent: January 7, 1986Assignee: Boehringer Mannheim GmbHInventors: Ulfert Deneke, Hans Lange, Walter Rittersdorf
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Patent number: 4551428Abstract: Esters and agents including the esters, useful as substrates for esterolytic and/or proteolytic enzymes, said esters being compounds of the general formula: ##STR1## in which R".sub.1, R".sub.2, R".sub.3 and R".sub.4, which may be the same or different, are hydrogen atoms or lower alkyl, lower alkoxy, alkylamino or dialkylamino radicals or in which two adjacent substituents can also represent a fused benzene ring, A is a residue of an amino acid or of a peptide and B is a nitrogen protective group conventional in peptide chemistry or derived therefrom; and the method of preparation and use.Type: GrantFiled: May 5, 1981Date of Patent: November 5, 1985Assignee: Boehringer Mannheim GmbHInventors: Dieter Berger, Gunter Frey, Wolfgang-Reinhold Knappe, Manfred Kuhr, Walter Rittersdorf, Wolfgang Werner
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Patent number: 4385114Abstract: The detection and determination of (a) hydrogen peroxide or of a substance which reacts with the formation of hydrogen peroxide or (b) of peroxidase or a peroxidatively active substance, is carried out by contacting an unknown sample with a chromogen and, in case (a), with a peroxidatively active substance or in case (b) with hydrogen peroxide or a substance which reacts with the formation of hydrogen peroxide, and evaluating the coloration produced by the reaction, wherein, as the chromogen, there is used at least one 3,3',5,5'-tetraalkylbenzidine compound of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which can be the same or different, are straight-chained or branched alkyl radicals containing up to 6 and preferably up to 4 carbon atoms.Type: GrantFiled: February 23, 1981Date of Patent: May 24, 1983Assignee: Boehringer Mannheim GmbHInventors: Werner Guthlein, Walter Rittersdorf, Hugo Tiedemann, Peter Vogel, Wolfgang Werner
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Patent number: 4300905Abstract: Compositions and methods for rapidly determining ascorbic acid in aqueous solutions, consisting of an absorbent carrier containing 2,18-phosphomolybdic acid, an aliphatic hydroxycarboxylic acid buffer to adjust the test to pH 2.5 to 5.0, and an alkali chlorate; process for the preparation of such tests.Type: GrantFiled: May 15, 1980Date of Patent: November 17, 1981Assignee: Boehringer Mannheim GmbHInventors: Manfred Bleisteiner, Walter Rittersdorf, Hans Wielinger
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Patent number: 4298498Abstract: The present invention provides a control reagent for test strips for the detection of urobilinogen and possibly of other diagnostically relevant components, such as bilirubin, ketone bodies, glucose, protein, nitrite and blood, and possibly also of pH, which has a content of 2,4-dimethylpyrrole-3-carboxylic acid and/or of at least one alkali metal and/or alkaline earth metal salt thereof as control substance for urobilinogen.Type: GrantFiled: December 13, 1979Date of Patent: November 3, 1981Assignee: Boehringer Mannheim GmbHInventors: Helmut Rehner, Walter Rittersdorf
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Patent number: 4297271Abstract: The invention provides a diagnostic agent for the detection of occult blood in feces comprising hydrogen peroxide and, as a chromogen, guaiaconic acid A, optionally with a stabilizer. The invention provides, as a novel substance, guaiaconic acid A having a specific extinction E.sub.1 cm.sup.1% at 600 nm of at least 200, determined by the reaction with peroxidase and hydrogen peroxide, having infra-red bands at1600 cm.sup.-1 (m);1505 cm.sup.-1 (v.s.);1206 cm.sup.-1 (s;b);1115 cm.sup.-1 (m);1025 cm.sup.-1 (m); and1200 cm.sup.-1 (s;b)and having an R.sub.F value of 0.45 (toluene/dioxan/glacial acetic acid; 90:25:10 v/v/v).Type: GrantFiled: January 25, 1980Date of Patent: October 27, 1981Assignee: Boehringer Mannheim GmbHInventors: Werner Guthlein, Hans Wielinger, Walter Rittersdorf, Wolfgang Werner
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Patent number: RE39915Abstract: An apparatus comprising a first porous carrier and a second porous carrier for evaluating biological fluid samples is disclosed. The apparatus is used for separating non high density lipoprotein (non-HDL) from a lipoprotein in a body sample and for determining high density lipoprotein (HDL) cholesterol in a HDL and non high density lipoprotein (non-HDL) in a body sample.Type: GrantFiled: August 20, 2003Date of Patent: November 6, 2007Assignee: Roche Diagnostics GmbHInventors: Walter Rittersdorf, Ulfert Deneke, Gerhard Hiller, Hartmut Merdes, Klaus Buecker, Uwe Goebbert