Patents by Inventor Walter Weyler

Walter Weyler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Detergent compositions and methods of use for an alpha-amylase polypeptide of species 195
    Patent number: 8470758
    Abstract: Disclosed herein are compositions comprising an alpha-amylase enzyme obtained from Bacillus sp. no. 195, and methods of using the enzyme to clean surfaces and textiles. Also disclosed are variants of the enzyme with different signal sequences.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: June 25, 2013
    Assignee: Danisco US Inc.
    Inventors: Neelam S. Amin, Melodie Estabrook, Brian E. Jones, Marc Kolkman, Casper Vroemen, Walter Weyler
  • TS-23 alpha-amylase variants with altered properties
    Patent number: 8460916
    Abstract: Described are variants (mutants) of a parent alpha-amylase having alpha-amylase activity and exhibiting altered properties relative to the parent alpha-amylase, and methods of use, thereof.
    Type: Grant
    Filed: July 2, 2012
    Date of Patent: June 11, 2013
    Assignee: Danisco US Inc.
    Inventors: Luis G. Cascao-Pereira, Claudine Chang, Clement Choy, James T. Kellis, Jr., Brian E. Jones, Melodie Estabrook, Marc Koklman, Chris Leeflang, Casper Vroeman, Walter Weyler
  • Enhanced protein expression in
    Patent number: 8383366
    Abstract: The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: February 26, 2013
    Assignee: Danisco US Inc.
    Inventors: Eugenio Ferrari, Carole Harbison, M. Harunur Rashid, Walter Weyler
  • TS-23 ALPHA-AMYLASE VARIANTS WITH ALTERED PROPERTIES
    Publication number: 20130005029
    Abstract: Described are variants (mutants) of a parent alpha-amylase having alpha-amylase activity and exhibiting altered properties relative to the parent alpha-amylase, and methods of use, thereof.
    Type: Application
    Filed: July 2, 2012
    Publication date: January 3, 2013
    Applicant: Danisco US Inc., Genencor Division
    Inventors: Luis G. CASCAO-PEREIRA, Claudine Chang, Clement Choy, James T. Kellis, JR., Brain E. Jones, Melodie Estabrook, Marc Kolkman, Chris Leeflang, Casper Vroemen, Walter Weyler
  • VARIANTS OF BACILLUS SP. TS-23 ALPHA-AMYLASE WITH ALTERED PROPERTIES
    Publication number: 20120252101
    Abstract: Variants of Bacillus sp. TS-23 strain alpha-amylases exhibit improved enzymatic performance, including increased themostability, reduced calcium dependence, increased washing/cleaning performance, and baking ability. Compositions comprising these variants are useful in methods of starch processing, starch liquefaction, fermatation, starch saccharification, cleaning, laundrying, textile desizing, baking, and biofilm removal.
    Type: Application
    Filed: March 2, 2012
    Publication date: October 4, 2012
    Applicant: Danisco US Inc.
    Inventors: Claudine Y. Chang, Clement Choy, Melodie Estabrook, Mansi Goyal, Thomas P. Graycar, Victoria E. Huang, Brian E. Jones, Marc Kolkman, Karsten M. Kragh, Chris Leeflang, Scott D. Power, Sandra W. Ramer, Andrew SHAW, Casper Vroemen, Walter Weyler
  • TS23 alpha-amylase variants with altered properties
    Patent number: 8236545
    Abstract: Described are variants (mutants) of a parent alpha-amylase having alpha-amylase activity and exhibiting altered properties relative to the parent alpha-amylase, and methods of use, thereof.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: August 7, 2012
    Assignee: Danisco US Inc., Genencor Division
    Inventors: Luis G. Cascao-Pereira, Claudine Chang, Clement Choy, James T. Kellis, Jr., Brian E Jones, Melodie Estabrook, Marc Kolkman, Chris Leeflang, Casper Vroemen, Walter Weyler
  • ENHANCED PROTEIN EXPRESSION IN BACILLUS
    Publication number: 20120183995
    Abstract: The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.
    Type: Application
    Filed: January 23, 2012
    Publication date: July 19, 2012
    Applicant: Danisco US Inc.
    Inventors: Eugenio Ferrari, Carole Harbison, M. Harunur Rashid, Walter Weyler
  • COMPOSITIONS AND METHODS FOR IMPROVED ISOPRENE PRODUCTION USING TWO TYPES OF ISPG ENZYMES
    Publication number: 20120164711
    Abstract: The invention provides for compositions and methods for producing isoprene by using recombinantly engineered cells that utilize a system of dual IspG enzymes in addition to isoprene synthase.
    Type: Application
    Filed: December 22, 2011
    Publication date: June 28, 2012
    Applicant: Danisco US Inc.
    Inventors: Rachel E. MUIR, Walter Weyler
  • Compositions and Uses for an Alpha-Amylase Polypeptide of Bacillus Species 195
    Publication number: 20120142074
    Abstract: Disclosed herein are compositions comprising an alpha-amylase enzyme obtained from Bacillus sp. no. 195, and methods of using the enzyme to clean surfaces and textiles. Also disclosed are variants of the enzyme with different signal sequences.
    Type: Application
    Filed: December 6, 2011
    Publication date: June 7, 2012
    Applicant: Danisco US Inc.
    Inventors: Neelam S. Amin, Melodie Estabrook, Brian E. Jones, Marc Kolkman, Casper Vroemen, Walter Weyler
  • Isoprene synthase variants for improved microbial production of isoprene
    Patent number: 8173410
    Abstract: The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
    Type: Grant
    Filed: April 23, 2009
    Date of Patent: May 8, 2012
    Assignee: Danisco US Inc.
    Inventors: Richard R. Bott, Marguerite A. Cervin, James T. Kellis, Jr., Joseph C. McAuliffe, Andrei Miasnikov, Caroline M. Peres, Christopher Lee Rife, Derek H. Wells, Walter Weyler, Gregory M. Whited
  • Variants of sp. TS-23 alpha-amylase with altered properties
    Patent number: 8153412
    Abstract: Variants of Bacillus sp. TS-23 strain alpha-amylases exhibit improved enzymatic performance, including increased themostability, reduced calcium dependence, increased washing/cleaning performance, and baking ability. Compositions comprising these variants are useful in methods of starch processing, starch liquefaction, fermatation, starch saccharification, cleaning, laundrying, textile desizing, baking, and biofilm removal.
    Type: Grant
    Filed: November 3, 2008
    Date of Patent: April 10, 2012
    Assignee: Danisco US Inc.
    Inventors: Claudine Y. Chang, Clement Choy, Melodie Estabrook, Mansi Goyal, Thomas P. Graycar, Victoria E. Huang, Brian E. Jones, Marc Kolkman, Karsten M. Kragh, Chris Leeflang, Scott D. Power, Sandra W. Ramer, Andrew Shaw, Casper Vroemen, Walter Weyler
  • Enhanced protein expression in
    Patent number: 8124399
    Abstract: The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: February 28, 2012
    Assignee: Danisco US Inc.
    Inventors: Eugenio Ferrari, Carole Harbison, M. Harunur Rashid, Walter Weyler
  • Compositions and uses for an alpha-amylase polypeptide of species 195
    Patent number: 8097444
    Abstract: Disclosed herein are compositions comprising an alpha-amylase enzyme obtained from Bacillus sp. no. 195, and methods of using the enzyme to clean surfaces and textiles. Also disclosed are variants of the enzyme with different signal sequences.
    Type: Grant
    Filed: December 6, 2007
    Date of Patent: January 17, 2012
    Assignee: Danisco US Inc.
    Inventors: Neelam S Amin, Melodie Estabrook, Brian E Jones, Marc Kolkman, Casper Vroemen, Walter Weyler
  • ISOPRENE PRODUCTION USING THE DXP AND MVA PATHWAY
    Publication number: 20110014672
    Abstract: The invention provides for methods for producing isoprene from cultured cells using various components of the DXP pathway and MVA pathway, or components associated with the DXP pathway and MVA pathway, iron-sulfur cluster-interacting redox polypeptides, and isoprene synthase. The invention also provides compositions that include these cultured cells.
    Type: Application
    Filed: June 16, 2010
    Publication date: January 20, 2011
    Inventors: Gopal K. Chotani, Joseph C. Mcauliffe, Michael C. Miller, Rachel Erin Muir, Dmitrii V. Vaviline, Walter Weyler
  • Enzyme for the Production of Long Chain Peracid
    Publication number: 20100330647
    Abstract: The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some embodiments, the present invention provides methods and compositions for generation of long chain peracids. Certain embodiments of the present invention find particular use in applications involving cleaning, bleaching and disinfecting.
    Type: Application
    Filed: May 21, 2010
    Publication date: December 30, 2010
    Inventors: NEELAM S. AMIN, RICHARD R. BOTT, MARGUERITE A. CERVIN, AYROOKARAN J. POULOSE, WALTER WEYLER
  • Enzyme for the production of long chain peracid
    Patent number: 7754460
    Abstract: The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some embodiments, the present invention provides methods and compositions for generation of long chain peracids. Certain embodiments of the present invention find particular use in applications involving cleaning, bleaching and disinfecting.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: July 13, 2010
    Assignee: Danisco US Inc.
    Inventors: Neelam S. Amin, Richard R. Bott, Marguerite A. Cervin, Ayrookaran J. Poulose, Walter Weyler
  • TS23 Alpha-Amylase Variants With Altered Properties
    Publication number: 20100048446
    Abstract: Described are variants (mutants) of a parent alpha-amylase having alpha-amylase activity and exhibiting altered properties relative to the parent alpha-amylase, and methods of use, thereof.
    Type: Application
    Filed: February 4, 2009
    Publication date: February 25, 2010
    Applicant: DANISCO US INC., GENENCOR DIVISION
    Inventors: Luis G. Cascao-Pereira, Claudine Chang, Clement Choy, James T. Kellis, JR., Brian E. Jones, Melodie Estabrook, Marc Kolkman, Chris Leeflang, Casper Vroemen, Walter Weyler
  • Compositions and Uses for an Alpha-Amylase Polypeptide of Bacillus Species 195
    Publication number: 20100035787
    Abstract: Disclosed herein are compositions comprising an alpha-amylase enzyme obtained from Bacillus sp. no. 195, and methods of using the enzyme to clean surfaces and textiles. Also disclosed are variants of the enzyme with different signal sequences.
    Type: Application
    Filed: December 6, 2007
    Publication date: February 11, 2010
    Inventors: Neelam S. Amin, Melodie Estabrook, Brian E. Jones, Marc Kolkman, Casper Vroemen, Walter Weyler
  • VARIANTS OF BACILLUS sp. TS-23 ALPHA-AMYLASE WITH ALTERED PROPERTIES
    Publication number: 20100021587
    Abstract: Variants of Bacillus sp. TS-23 strain alpha-amylases exhibit improved enzymatic performance, including increased themostability, reduced calcium dependence, increased washing/cleaning performance, and baking ability. Compositions comprising these variants are useful in methods of starch processing, starch liquefaction, fermatation, starch saccharification, cleaning, laundrying, textile desizing, baking, and biofilm removal.
    Type: Application
    Filed: November 3, 2008
    Publication date: January 28, 2010
    Applicant: Danisco US Inc., Genencor Division
    Inventors: CLAUDINE Y. CHANG, CLEMENT CHOY, MELODIE ESTABROOK, MANSI GOYAL, THOMAS P. GRAYCAR, VICTORIA E. HUANG, BRIAN E. JONES, MARC KOLKMAN, KARSTEN M. KRAGH, CHRIS LEEFLANG, SCOTT D. POWER, SANDRA W. RAMER, ANDREW SHAW, CASPER VROEMEN, WALTER WEYLER
  • ISOPRENE SYNTHASE VARIANTS FOR IMPROVED MICROBIAL PRODUCTION OF ISOPRENE
    Publication number: 20100003716
    Abstract: The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
    Type: Application
    Filed: April 23, 2009
    Publication date: January 7, 2010
    Inventors: Marguerite A. Cervin, Gregory M. Whited, Andrei Miasnikov, Caroline M. Peres, Walter Weyler, Derek H. Wells, Richard R. Bott