Abstract: The present invention relates to a method for preparing biodegradable microspheres using a single-phase mixed solution containing water, alcohol, and dichloromethane. Provided is a method for preparing a biodegradable microsphere having a uniform drug loading efficiency by preparing and using a single-phase mixed solution in which no phase separation occurs without using a thickener and a surfactant. The preparation method of the present invention has the feature of keeping the content of a loaded drug uniform until a final biodegradable microsphere is prepared, by using a single-phase mixed solution in which no phase separation by a solvent occurs in the preparation process. Thus, the preparation method of the present invention is remarkably useful for the preparation of biodegradable microspheres.

Abstract: Disclosed is a compact integrated apparatus of an interferometric radar altimeter (IRA) and a radar altimeter (RA) capable of performing individual missions by altitude, which includes: a plurality of antennas; a signal processing control unit selecting an RA mode at a low altitude and selecting an IRA mode at a high altitude based on a mode threshold and selecting an FMCW waveform at the low altitude and selecting an FM pulse waveform at the high altitude based on a waveform threshold; and a transceiving unit transmitting a signal by a first antenna positioned at an outermost portion among the plurality of antennas and receiving a signal by an nth antenna positioned at another outermost portion among the plurality of antennas in the RA mode and transmitting a signal through the first antenna and receiving signals through the plurality of antennas in the IRA mode.

Abstract: Disclosed is a compact integrated apparatus of an interferometric radar altimeter (IRA) and a radar altimeter (RA) capable of performing individual missions by altitude, which includes: a plurality of antennas; a signal processing control unit selecting an RA mode at a low altitude and selecting an IRA mode at a high altitude based on a mode threshold and selecting an FMCW waveform at the low altitude and selecting an FM pulse waveform at the high altitude based on a waveform threshold; and a transceiving unit transmitting a signal by a first antenna positioned at an outermost portion among the plurality of antennas and receiving a signal by an nth antenna positioned at another outermost portion among the plurality of antennas in the RA mode and transmitting a signal through the first antenna and receiving signals through the plurality of antennas in the IRA mode.

Abstract: The present invention relates to a method for preparing biodegradable microspheres using a single-phase mixed solution containing water, alcohol, and dichloromethane. Provided is a method for preparing a biodegradable microsphere having a uniform drug loading efficiency by preparing and using a single-phase mixed solution in which no phase separation occurs without using a thickener and a surfactant. The preparation method of the present invention has the feature of keeping the content of a loaded drug uniform until a final biodegradable microsphere is prepared, by using a single-phase mixed solution in which no phase separation by a solvent occurs in the preparation process. Thus, the preparation method of the present invention is remarkably useful for the preparation of biodegradable microspheres.

Abstract: Provided is a shell including: a shell body; a steering wing including a drive shaft and that mounted on an external surface of the shell body; an auxiliary wing including a shaft connection portion which is connected to the drive shaft and moving in the lengthwise direction of the drive shaft within the drive shaft to be inserted into and be spread outward from within the steering wing; an auxiliary-wing holding unit including a holding protrusion which is fixedly arranged in a direction of intersecting the shaft connection portion to selectively hold the auxiliary wing in place; and an auxiliary-wing spreading unit installed within the drive shaft, and that provides driving force for spreading the auxiliary wing outward from within the steering wing when the holding protrusion is disengaged with the shaft connection portion.

Abstract: The present invention relates to a method for preparing an ionic liquid having a carboxylic acid anion using a microreactor. More specifically, the present invention relates to a method for preparing, with high efficiency, an ionic liquid having a carboxylic acid anion as shown in FIG. 1, by having sodium butanoate, sodium 2-ethylhexanoate, or sodium octanoate undergo a substitution reaction with 1-alkyl-3-methylimidazolium, 1,1-alkylmethylpyrrolidinium, 1,2-dimethyl-3-alkylimidazolium, 1-alkyl-3-methylpyridinium, or tetramethylammonium, each of which being a cation. The ionic liquid prepared according to the present invention has high purity, containing residual halide at less than 10 ppm, and has high electrical conductivity, and therefore is capable of being used as an electrolyte or for a condenser.

Abstract: Provided is a shell including: a shell body; a steering wing including a drive shaft and that mounted on an external surface of the shell body; an auxiliary wing including a shaft connection portion which is connected to the drive shaft and moving in the lengthwise direction of the drive shaft within the drive shaft to be inserted into and be spread outward from within the steering wing; an auxiliary-wing holding unit including a holding protrusion which is fixedly arranged in a direction of intersecting the shaft connection portion to selectively hold the auxiliary wing in place; and an auxiliary-wing spreading unit installed within the drive shaft, and that provides driving force for spreading the auxiliary wing outward from within the steering wing when the holding protrusion is disengaged with the shaft connection portion.

Abstract: An apparatus for detecting a target in near field in accordance with an exemplary embodiment of the present invention includes: an RF transceiver configured to generate a transmitting signal of a frequency modulated continuous wave (FMCW) and delay the signal as much as a desired time; a transmitting and receiving antenna unit configured to transmit and receive the a transmitting signal and the received signal; and a signal processing unit configured to extract a range or a velocity of the target from the signal provided from the RF transceiver.

Abstract: The present invention relates to a preparation method, which involves synthesizing BMIM/Cl, which is an ionic liquid, from AlCl3 and TiCl4, which are Lewis acids, and which enables the synthesized body to be supported by Al2O3 serving as a support. The preparation method of the present invention uses AlCl3 and TiCl4, which are not used in existing methods, so as to prepare a supported ionic liquid. The preparation method of the present invention uses water as a solvent to efficiently relieve reaction conditions and avoid the risk of heating during the reaction, and thus enables supported ionic-liquid products to be continuously prepared in a stable manner.

Abstract: A method of fabricating a two-terminal semiconductor component using a trench technique is disclosed that includes forming a trench by etching an etching pattern formed on a substrate on which an active layer having impurities added is grown, forming a front metal layer on a front upper surface of the substrate by using an evaporation method or a sputtering method after removing the etching pattern, forming a metal plated layer on the front surface of the substrate on which the front metal layer is formed, polishing a lower surface of the substrate by using at least one of a mechanical polishing method and a chemical polishing method until the front metal layer is exposed, forming a rear metal layer on the polished substrate, and removing each component by using at least one of a dry etching method and a wet etching method.

Abstract: The present invention relates to tricyclic colchicine derivatives represented by the formulas (I) or (II), pharmaceutically acceptable salts thereof, and a method for providing an immuno-suppressive or immuno-modulating effect, an anti-proliferative effect, an anti-inflammatory effect or a method for treating cancer comprising administering to a patient an effective amount of one or more colchicine derivatives:

Abstract: Colchicine derivatives represented by the formula (I) with a halogen or nitric ester group, or pharmaceutically acceptable salts thereof, are described. Pharmaceutical compositions containing the same as effective components are also described. The colchicine derivatives were found to have anticancer, anti-proliferous and immunosuppressive function. Methods for preparing the colchicines derivatives are also provided.

Abstract: Colchicine derivatives represented by the formula (I) 1

Abstract: An erythromycin A 9-O-benzodithiol oxime intermediate represented by the following formula (III) useful for synthesis of clarthromycin and crystalline solvate thereof: Wherein, Y1 and Y2 are independently a hydrogen atoms or trimethylsilyl groups. And, a process for the preparation of clarithromycin using the erythromycin A 9-O-benzodithiol oxime intermediate as described in the specification.

Abstract: Form II crystals of clarithromycin can be easily prepared by treating clarithromycin of different crystal forms with water or with a mixture of water and a water-immiscible organic solvent and isolating treated crystals by filtration.

Abstract: The present invention elates to a process for preparing paclitaxel represented by formula (1) characterized in that: (a) an oxazolidine derivative represented by formula (2) or its salt in which X represents halogen, is coupled with a 7-trihaloacetyl-baccatin III represented by formula (3) in which R.sub.1 represents trihaloacetyl, in a solvent in the presence of a condensing agent to produce an oxazolidine substituent-containing taxane represented by formula (4) in which X and R.sub.1 are each as previously defined; (b) the oxazolidine ring is opened in a solvent in the presence of an acid, and the product thus obtained is reacted with benzoyl chloride in the presence of a base to produce a protected paclitaxel wherein the hydroxy group at 7-position is protected with trihaloacetyl group represented by formula (5) in which R.sub.1 is as previously defined; (c) then the protecting group at 7-position is removed by ammonia or a salt of ammonia with a weak acid in a solvent.

Abstract: The present invention relates to optical isomers of quinoline compounds of Formula (IA) or Formula (IA'), their pharmaceutically acceptable salts and their intermediates: ##STR1## In the above formulae, A represent nitrogen or ##STR2## in which Y represents hydrogen, halogen such as fluorine or chlorine, lower alkyl or lower alkoxy such as methoxy, or together with R.sub.1 forms --CH.sub.2 CH.sub.2 CH.sub.2 --, CH.sub.2 CH.sub.2 CH(CH.sub.3)--, --OCH.sub.2 CH.sub.2 --, --OCH.sub.2 CH(CH.sub.3)--, --SCH.sub.2 CH.sub.2 -- or --SCH.sub.2 CH(CH.sub.3)--; R.sub.1 is as defined above or represents straight chain or cyclic lower alkyl group having 1 to 3 carbon atoms, a straight chain or cyclic lower alkyl group having 1 to 3 carbon atoms which is substituted with a halogen atom, a phenyl group or a phenyl group substituted with one or two halogen atoms, such as ethyl, cyclopropyl or 2,4-difluorophenyl; R.sub.

Abstract: The present invention relates to quinoline derivatives substituted in the 7-position by a trans-2,8-diazabicyclo?4.3.0!nonan-8-yl group having a broad antibacterial spectrum and to processes for preparing the same.

Abstract: The present invention relates to optical isomers of quinoline compounds of Formula (IA) or Formula (IA'), their pharmaceutically acceptable salts and their intermediates: ##STR1## In the above formulae, A represent nitrogen or ##STR2## in which Y represents hydrogen, halogen such as fluorine or chlorine, lower alkyl or lower alkoxy such as methoxy, or together with R.sub.1 forms --CH.sub.2 CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 CH(CH.sub.3)--, --OCH.sub.2 CH.sub.2 --, --OCH.sub.2 CH(CH.sub.3)--, --SCH.sub.2 CH.sub.2 -- or --SCH.sub.2 CH(CH.sub.3)--;R.sub.1 is as defined above or represents straight chain or cyclic lower alkyl group having 1 to 3 carbon atoms, a straight chain or cyclic lower alkyl group having 1 to 3 carbon atoms which is substituted with a halogen atom, a phenyl group or a phenyl group substituted with one or two halogen atoms, such as ethyl, cyclopropyl or 2,4-difluorophenyl;R.sup.