Abstract: The present disclosure relates to mTOR inhibitors. Specifically, the embodiments are directed to compounds and compositions inhibiting mTOR, methods of treating diseases mediated by mTOR, and methods of synthesizing these compounds.

Abstract: Electronic assemblies and methods of attaching retention structures are described. The electronic assemblies may include a receiving substrate and a retention structure bonded to the receiving substrate. The retention structure may be patterned to include openings such as slot openings or a fishbone pattern in order to receive a pair of solder joints to bond the retention structure to a top side of the receiving substrate.

Abstract: A method of analyzing source code includes receiving, by a processor, an updated version of a computer program, the updated version including a source code. The method also includes preprocessing, by a compiler, the source code for a target computing platform. Preprocessing the source code by the compiler includes identifying a macro condition associated with one or more computer instructions enclosed by a macro, determining object code corresponding to the one or more computer instructions based on a current value of the macro condition, and generating object code and macro information for output to a debugger, the macro information including one or more breakpoint conditions in the macro.

Abstract: An embodiment of an LED lamp that generates light of a color temperature that decreases with decreasing power applied to the LED lamp may include at least one lighting arrangement that may include a first LED array of serially connected first LED chips, a second LED array of serially connected second LED chips; a first photoluminescence layer covering the first LED array for generating light of a first color temperature; a second photoluminescence layer covering the second LED array for generating light of a second different color temperature; and a linear resistor serially connected to the first LED array, wherein the first LED array and second LED array are connected in parallel.

Abstract: The present invention relates to a preparation method of a P-type high-resistance and ultra-high-resistance Czochralski monocrystalline silicon substrate. According to the present invention, an oxygen concentration in a silicon wafer is controlled to match with a resistivity, so as to realize that a conductive type of the silicon substrate does not change after a device is manufactured, and that the silicon substrate has a high resistivity. The oxygen concentration and the resistivity in silicon crystal can be adjusted separately or together; and operation is flexible, and a yield of a high-resistance silicon crystal is greatly improved.

Abstract: Disclosed are a derivative of a 2,5-diketopiperazine compound, and a preparation method therefor, a pharmaceutical composition thereof and the use thereof. Specifically, disclosed are a compound as represented by formula (I), a stereoisomer thereof, a tautomer thereof or a pharmaceutically acceptable salt thereof, or a solvate of any one of the aforementioned. The compound is new in terms of structure, and has good anti-tumor activity and water solubility.

Abstract: The present invention is related to a novel positive electrode active material for lithium-ion battery. The positive electrode active material is expressed by the following formula: Li1.2NixMn0.8-x-yZnyO2, wherein x and y satisfy 0<x?0.8 and 0<y?0.1. In addition, the present invention provides a method of manufacturing the positive electrode active material. The present invention further provides a lithium-ion battery which uses said positive electrode active material.

Abstract: Provided is a fusion protein dimer using an antibody Fc region as the backbone, comprising a first and a second polypeptide chain. The first polypeptide chain comprises a first antibody Fc region and one or more single-domain antibodies fused to the first antibody Fc region. The second polypeptide chain comprises a second antibody Fc region and one or more single domain antibodies fused to the second antibody Fc region. The first polypeptide chain and/or the second polypeptide chain further comprise a cytokine fused to the Fc region of the respective antibody. Further provided is use of the fusion protein dimer in preparing an immunotherapeutic drug for treating tumors. The Fc fusion protein heterodimer not only increases the activity of a single domain antibody, but also significantly improves the biological activity of a cytokine.

Abstract: Systems and methods which provide a motion sensor data-driven framework for sports action recognition and/or assessment using a wearable sensor are described. A motion sensor data-driven system may provide real-time kinematical analysis to athletes engaged in active competition or training sessions under typical competition or training conditions. Analysis of motion sensor data provided according to embodiments may operate to recognize instances of one or more particular sports actions performed by an athlete and/or assess the skill of the athlete from analysis of one or more sports actions. A motion sensor data processing platform of embodiments of a motion sensor data-driven system may comprise a processor-based system configured to receive and analyze data regarding the movement of an athlete's limb reported by a wearable sensor device comprising a micro inertial measurement unit configuration for capturing and reporting data regarding the movement of an athlete's limb.

Abstract: A data transmission apparatus includes: a first port and a second port which are selected by a first control signal; a first signal path and a second signal path which are selected by a second control signal. When a memory card satisfies a first condition, the first control signal selects the first port and the second control signal selects the first signal path, the data transmission apparatus connects the host device and the memory card via the first port and the first signal path and works in a first transmission mode. When the memory card satisfies a second condition, the first control signal selects the second port and the second control signal selects the second signal path, the data transmission apparatus connects the host device and the memory card via the second port and the second signal path and works in a second transmission mode.

Abstract: Engineered bispecific antibodies with charge pairs introduced at the interface of CHI and CL alone or in combination with other charge pairs at the interface of VH and VL are described. Also described are anti-CD47/anti-CLDN18.2 and anti-CD3/anti-DLL3 bispecific antibodies and antigen-binding fragments thereof. Also described are nucleic acids encoding the bispecific antibodies, compositions comprising the bispecific antibodies, and methods of producing the bispecific antibodies and using the bispecific antibodies for treating or preventing diseases, such as cancer and/or associated complications.

Abstract: This application relates to compounds of Formula I: or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are useful for the treatment of disorders such as cancer.

Abstract: Method and apparatus for configuring channel characteristics of a reference signal, and a communication device are described. The method includes determining first type signaling, where the first type signaling carries a first type set and the first set includes a plurality of index elements; and sending the first type signaling to a second communication node.

Abstract: An LED-filament comprising: a partially light transmissive substrate; a plurality of LED chips on a front face of the substrate; a photoluminescence material that is in direct contact with and covers all of the plurality of LED chips; and a light scattering layer that is in direct contact with and covers at least the photoluminescence material, wherein the light scattering layer comprises particles of light scattering material, and wherein the photoluminescence material comprises broadband green to red photoluminescence materials and narrowband red photoluminescence material.

Abstract: A memory device and a method of operating a memory device are disclosed. In one aspect, the memory device includes a plurality of non-volatile memory cells, each of the plurality of non-volatile memory cells is operatively coupled to a word line, a gate control line, and a bit line. Each of the plurality of non-volatile memory cells comprises a first transistor, a second transistor, a first diode-connected transistor, and a capacitor. The first transistor, second transistor, first diode-connected transistor are coupled in series, with the capacitor having a first terminal connected to a common node between the first diode-connected transistor and the second transistor.

Abstract: A routing information management method adapted for a layer-3 switch is proposed. For each ARP entry in an ARP table, a processor assigns to the ARP entry an aging reference parameter that is identical to a quantity of those routing entries in an IP routing table whose next hop IP addresses are identical to the IP address of the ARP entry, and removes those ARP entries whose aging reference parameters are zero. For each routing entry in the IP routing table, when the next hop IP address of the routing entry is absent from the ARP table, the processor makes the routing entry serve as an inactive routing entry, proactively sends an ARP request for the inactive routing entry, and updates the ARP table based on a piece of ARP information received externally.

Abstract: A method and system for the generation of a medium-Btu, clean and renewable fuel gas to replace fossil fuels in existing lime kilns with minimal retrofitting without significantly compromising the kiln capacity. A steam-blown dual fluidized bed gasifier produces renewable fuel gas from a carbonaceous feedstock such as woody biomass. A gas cleanup process purifies the raw fuel gas, resulting in a clean fuel gas for mitigation of lime contamination and environmental issues. The adiabatic flame temperature and flue gas volume/GJ for the combustion of the renewable fuel gas are similar to values for natural gas, making retrofitting of fossil fuel-fired lime kilns relatively straightforward.

Abstract: A touch panel and an electronic device are provided in the disclosure. The touch panel includes multiple touch units spaced apart from each other. Each touch unit includes a driving electrode and detection electrodes. The driving electrode includes a first driving branch and multiple second driving branches spaced apart from each other. The multiple second driving branches are connected with the first driving branch. Two adjacent second driving branches and the first driving branch define at least one receiving space. Each receiving space receives at least one of the detection electrodes. Each detection electrode is electrically connected with a touch-detection signal line, and different detection electrodes are electrically connected with different touch-detection signal lines, respectively.

Abstract: Embodiments of the present disclosure provide an information determination method and device, an electronic device and a storage medium. The method includes: determining a reference signal in a case where a preset condition is satisfied; and determining information of a downlink signal or downlink channel according to the reference signal. The embodiments of the present disclosure solve a problem that physical downlink shared channels (PDSCHs) of multiple component carriers (CCs) cannot be received normally due to conflict of the PDSCHs of the CCs in a time domain in the related art.

Abstract: The present disclosure is directed to inhibitors of SHP2 and their use in the treatment of disease. Also disclosed are pharmaceutical compositions comprising the same.