Abstract: The present invention features an optical detection system for SARS-CoV-2 or other pathogens, which includes a specialty mask. The specialty mask incorporates a SERS nanopatch for accumulating pathogenic particles from a wearers breath. When the SERS nanopatch receives incident NIR light, backscattered light from the SERS nanopatch is detected by a receiver and analyzed for a Raman spectral shift. Detection of the Raman spectral signature from the SERS nanopatch allows for determination if SARS-CoV-2 or another pathogen is present. In addition to the mask with a nanostructured surface for collecting pathogenic material, the system includes a laser source directed at the nanostructured surface, a detection system to collect backscattered light, a spectral analysis system to detect Raman shifted light, and an analysis system for determining if SARS-CoV-2 or another pathogen is present. AI image processing may be used to steer the laser beam safely to the nanopatch, avoiding eye contact.

Abstract: A method and apparatus for performing a laser treatment of a patient includes applying a positive pressure impulse on a predetermined target site on the patient with sufficient positive pressure arising from the momentum flux of sprayed material incident on the target site to momentarily lessen pain sensation during irradiation during or proximate in time to irradiation of the target site. The predetermined target site is cooled by applying a predetermined amount of coolant or cryogen onto the target site. The target site is radiated with energy to produce heat in tissue at the target site while leaving a superficial part of the target site substantially undamaged due to dynamic cooling of the superficial part of the target site by the coolant. Mediation of the pain sensation arising from the radiation is at least partially masked or lessened by the positive pressure impulse and/or by the temperature of the coolant.