Patents by Inventor Wanqin ZHANG
Wanqin ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11939399Abstract: A synthetic peptide sp4 has an amino acid sequence shown in SEQ ID NO: 1. As the sole effective ingredient in the antitumor efficacy test, it has a significant inhibitory effect on both the tumor volume and tumor weight of human osteosarcoma MG-63 in nude mice and has a significant dose-effect and time-effect relationship. There is no difference between the relative tumor growth rate T/C (%) of sp4 and that of the positive control group of Paclitaxel. The safety of sp4 is that its maximal tolerated dose for intravenous administration is 700 mg/kgBW. Sp4 has clear targets of pharmacological effects, while having efficacy in vivo, it also has an inhibitory effect on tumor telomerase, has an arrest on G1 phase of the tumor cell cycle, and inhibits the high expressions of tumor PD-L1 and CD47. The present disclosure relates to multiple uses of sp4, especially in the preparation of a class of antitumor drugs.Type: GrantFiled: March 24, 2022Date of Patent: March 26, 2024Assignee: TAIAN CITY QIHANG BIOTECHNOLOGY CO.Inventors: Wanqin Zhang, Yintian Li, Xuewen Ji, Limei Zhao
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Patent number: 11566098Abstract: A graphene-modified elastomer material and its preparation method. The elastomer material comprises a first component and a second component; the first component comprises isocyanate prepolymer obtained through reaction of polyol and isocyanate, and the isocyanate prepolymer has a —NCO content of 22-30%; the second component comprises the following components in parts by weight: 60-90 parts of polyetheramine, 1-10 parts of liquid amine chain extender, 1-5 parts of polytetrahydrofuran ether polyol, and 1-5 parts of graphenes. Through adjusting the —NCO content of the isocyanate prepolymer, increasing the hard segment content, and combining with the components in the second component, the invention ensures the elasticity of the polymer while improving its mechanical properties such as hardness and bending strength.Type: GrantFiled: January 21, 2020Date of Patent: January 31, 2023Assignee: ZHEJIANG YUANRONG TECHNOLOGY CO., LTDInventors: Songmao Yu, Lvming Xiao, Yangang Yu, Wanqin Zhang, Qiwei Zheng
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Publication number: 20220389060Abstract: A synthetic peptide sp2 has the amino acid sequence shown in SEQ ID No: 1. sp2 has obvious anti-tumor growth activity on xenograft tumours such as subcutaneous human pancreatic cancer, human cervical cancer, and human ovarian cancer in nude mice, with a dose-effect and time-effect relation; and has the effect of delaying metastasis and prolonging the survival time of nude mouse having in situ transplantation of human pancreatic cancer and lung adenocarcinoma. After the animals were given intravenous injection of sp2 at a dose of 2000 mg/kgBW, no toxicity reaction and death were observed. The applications of sp2 also include: (1) preventing and/or treating of tumor; (2) inhibiting proliferation and/or growth and/or invasion of tumor cells; (3) enhancing the anti-tumor immune response; (4) inducing tumor cell differentiation; (5) preparing anti-tumor drugs; (6) inhibiting tumor telomerase activity; and (7) regulating the tumor cell cycle.Type: ApplicationFiled: June 30, 2022Publication date: December 8, 2022Inventors: Wanqin ZHANG, Yintian LI, Xuewen JI, Limei ZHAO
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Patent number: 11485857Abstract: An amino silicone oil-modified elastomer material includes Component A and Component R. Component A includes isocyanate prepolymer obtained through reaction of polyol and isocyanate, and the isocyanate prepolymer has a —NCO content of 22-30%; Component R includes the following components in parts by weight: 45-60 parts of polyether amine, 1-6 parts of liquid amine chain extender, 1-10 parts of polysulfide rubber, 2-8 parts of nano silica, and 3-8 parts of amino silicone oil. The elastomer material of the invention ensures the elasticity of the polymer while improving mechanical properties. Moreover, it can improve elongation, wear resistance and water resistance of the polyurea material.Type: GrantFiled: January 21, 2020Date of Patent: November 1, 2022Assignee: Zhejiang Yuanrong Technology Co., LtdInventors: Songmao Yu, Lvming Xiao, Yangang Yu, Wanqin Zhang, Qiwei Zheng
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Patent number: 11485819Abstract: An elastomer material includes at least two components; the first component includes isocyanate prepolymer obtained through reaction of polyol and isocyanate, and its —NCO content is 22-30%; the second component includes 50-70 parts of polyether amine, 2-10 parts of liquid amine chain extender, 5-15 parts of hydroxyl-terminated polybutadiene, and 1-15 parts of hybrid hard segment material; the hybrid hard segment material includes one or more of nano titanium dioxide, nano aluminum oxide and nano silica. Through adjusting the —NCO content of the isocyanate prepolymer, increasing the hard segment content, and combining with the components in the second component, the invention ensures the elasticity of the polymer while improving its mechanical properties, and also improves the electrical insulation and wear resistance of the material.Type: GrantFiled: January 22, 2020Date of Patent: November 1, 2022Assignee: Zhejiang Yuanrong Technology Co., LtdInventors: Songmao Yu, Lvming Xiao, Yangang Yu, Wanqin Zhang, Qiwei Zheng
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Publication number: 20220332761Abstract: A synthetic peptide sp4 has an amino acid sequence shown in SEQ ID NO: 1. As the sole effective ingredient in the antitumor efficacy test, it has a significant inhibitory effect on both the tumor volume and tumor weight of human osteosarcoma MG-63 in nude mice and has a significant dose-effect and time-effect relationship. There is no difference between the relative tumor growth rate T/C (%) of sp4 and that of the positive control group of Paclitaxel. The safety of sp4 is that its maximal tolerated dose for intravenous administration is 700 mg/kgBW. Sp4 has clear targets of pharmacological effects, while having efficacy in vivo, it also has an inhibitory effect on tumor telomerase, has an arrest on G1 phase of the tumor cell cycle, and inhibits the high expressions of tumor PD-L1 and CD47. The present disclosure relates to multiple uses of sp4, especially in the preparation of a class of antitumor drugs.Type: ApplicationFiled: March 24, 2022Publication date: October 20, 2022Inventors: Wanqin ZHANG, Yintian LI, Xuewen JI, Limei ZHAO
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Synthetic peptide BRAP and application in preparation of anti-inflammatory drug for COVID-19 thereof
Patent number: 11401303Abstract: A synthetic peptide brap can be used in preparing an anti-inflammatory drug for COVID-19. The amino acid sequence of a synthetic peptide brap is as shown in SEQ ID No: 1. The synthetic bradykinin receptor antagonism peptide (brap) has significant target-docking and inhibiting effects on G-protein-coupled bradykinin B1 and B2 receptors. The intranasal administration of brap has local effects on allergic nasal inflammation, and has systemic pharmacodynamic effect on pulmonary leakage, lung injury and LPS-induced cytokine storm. The intravenous injection of brap has an obvious inhibiting effect on the excessive inflammation, oxidative stress response and serious lung injury emerging in LPS-induced mice; and has an obvious inhibiting effect on the excessive release of proinflammatory factors IL-6 and TNF-?, overexpression of IL-6 mRNA, and massive generation of reactive oxygen species (ROS) in the LPS-induced inflammatory factor storm.Type: GrantFiled: March 3, 2020Date of Patent: August 2, 2022Assignee: TAIAN CITY QIHANG BIOTECHNOLOGY CO.Inventors: Wanqin Zhang, Yintian Li, Xuewen Ji, Limei Zhao -
SYNTHETIC PEPTIDE BRAP AND APPLICATION IN PREPARATION OF ANTI-INFLAMMATORY DRUG FOR COVID-19 THEREOF
Publication number: 20220144891Abstract: A synthetic peptide brap can be used in preparing an anti-inflammatory drug for COVID-19. The amino acid sequence of the synthetic peptide brap is as shown in SEQ ID No. 1. The synthetic peptide brap has significant target-docking and inhibiting effects on G-protein-coupled bradykinin B1 and B2 receptors; the intranasal administration of brap has local effects on allergic nasal inflammation, and has systemic pharmacodynamic effect on pulmonary leakage, lung injury and LPS-induced cytokine storm. The intravenous injection of brap has an obvious inhibiting effect on the excessive inflammation, oxidative stress response and serious lung injury emerging in LPS-induced mice; and has an obvious inhibiting effect on the excessive release of proinflammatory factors IL-6 and TNF-?, overexpression of IL-6 mRNA, and massive generation of reactive oxygen species (ROS) in the LPS-induced inflammatory factor storm.Type: ApplicationFiled: March 3, 2021Publication date: May 12, 2022Inventors: Wanqin ZHANG, Yintian LI, Xuewen JI, Limei ZHAO -
Publication number: 20210261618Abstract: A synthetic peptide sp2 has the amino acid sequence shown in SEQ ID No. 1. sp2 has obvious anti-tumor growth activity on xenograft tumours such as subcutaneous human pancreatic cancer, human cervical cancer, and human ovarian cancer in nude mice, with a dose-effect and time-effect relation; and has the effect of delaying metastasis and prolonging the survival time of nude mouse having in situ transplantation of human pancreatic cancer and lung adenocarcinoma. After the animals were given intravenous injection of sp2 at a dose of 2000 mg/kgBW, no toxicity reaction and death were observed. The applications of sp2 also include: (1) preventing and/or treating of tumor; (2) inhibiting proliferation and/or growth and/or invasion of tumor cells; (3) enhancing the anti-tumor immune response; (4) inducing tumor cell differentiation; (5) preparing anti-tumor drugs; (6) inhibiting tumor telomerase activity; and (7) regulating the tumor cell cycle.Type: ApplicationFiled: November 15, 2018Publication date: August 26, 2021Inventors: Wanqin ZHANG, Yintian LI, Xuewen JI, Limei ZHAO
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Publication number: 20210179664Abstract: A synthetic peptide sp4 has an amino acid sequence shown in SEQ ID NO: 1. As the sole effective ingredient in the antitumor efficacy test, it has a significant inhibitory effect on both the tumor volume and tumor weight of human osteosarcoma MG-63 in nude mice and has a significant dose-effect and time-effect relationship. There is no difference between the relative tumor growth rate T/C (%) of sp4 and that of the positive control group of Paclitaxel. The safety of sp4 is that its maximal tolerated dose for intravenous administration is 700 mg/kgBW. Sp4 has clear targets of pharmacological effects, while having efficacy in vivo, it also has an inhibitory effect on tumor telomerase, has an arrest on G1 phase of the tumor cell cycle, and inhibits the high expressions of tumor PD-L1 and CD47. The present disclosure relates to multiple uses of sp4, especially in the preparation of a class of antitumor drugs.Type: ApplicationFiled: October 12, 2018Publication date: June 17, 2021Inventors: Wanqin ZHANG, Yintian LI, Xuewen JI, Limei ZHAO
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Patent number: 10870680Abstract: A scorpion venom heat-resistant synthetic peptide (SVHRSP) contains an amino acid sequence of SEQ ID NO 1. One or more amino acids the amino acid sequence can be substituted or deleted. A pharmaceutical composition that contains the SVHRSP has numerous applications. The pharmaceutical composition can be used to protect neuronal cell against amyloid beta-induced toxic effects, or to inhibit the sodium channel current of a hippocampal neuronal cell, or to protect a neuronal cell against NMDA-induced injury. It may also promote the formation of a pluripotent neural stem cell from a type II astrocyte, or treats a subject, such as a human, having epilepsy, Alzheimer's disease, or Parkinson's disease.Type: GrantFiled: September 17, 2019Date of Patent: December 22, 2020Assignee: DALIAN MEDICAL UNIVERSITYInventors: Jie Zhao, Shao Li, Wanqin Zhang
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Publication number: 20200291229Abstract: An amino silicone oil-modified elastomer material includes Component A and Component R. Component A includes isocyanate prepolymer obtained through reaction of polyol and isocyanate, and the isocyanate prepolymer has a —NCO content of 22-30%; Component R includes the following components in parts by weight: 45-60 parts of polyether amine, 1-6 parts of liquid amine chain extender, 1-10 parts of polysulfide rubber, 2-8 parts of nano silica, and 3-8 parts of amino silicone oil. The elastomer material of the invention ensures the elasticity of the polymer while improving mechanical properties. Moreover, it can improve elongation, wear resistance and water resistance of the polyurea material.Type: ApplicationFiled: January 21, 2020Publication date: September 17, 2020Applicant: Zhejiang Yuanrong Technology Co., LtdInventors: Songmao YU, Lvming XIAO, Yangang YU, Wanqin ZHANG, Qiwei ZHENG
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Publication number: 20200291167Abstract: A graphene-modified elastomer material and its preparation method. The elastomer material comprises a first component and a second component; the first component comprises isocyanate prepolymer obtained through reaction of polyol and isocyanate, and the isocyanate prepolymer has a —NCO content of 22-30%; the second component comprises the following components in parts by weight: 60-90 parts of polyetheramine, 1-10 parts of liquid amine chain extender, 1-5 parts of polytetrahydrofuran ether polyol, and 1-5 parts of graphenes. Through adjusting the —NCO content of the isocyanate prepolymer, increasing the hard segment content, and combining with the components in the second component, the invention ensures the elasticity of the polymer while improving its mechanical properties such as hardness and bending strength.Type: ApplicationFiled: January 21, 2020Publication date: September 17, 2020Applicant: Zhejiang Yuanrong Technology Co., LtdInventors: Songmao YU, Lvming XIAO, Yangang YU, Wanqin ZHANG, Qiwei ZHENG
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Publication number: 20200291171Abstract: An elastomer material includes at least two components; the first component includes isocyanate prepolymer obtained through reaction of polyol and isocyanate, and its —NCO content is 22-30%; the second component includes 50-70 parts of polyether amine, 2-10 parts of liquid amine chain extender, 5-15 parts of hydroxyl-terminated polybutadiene, and 1-15 parts of hybrid hard segment material; the hybrid hard segment material includes one or more of nano titanium dioxide, nano aluminum oxide and nano silica. Through adjusting the —NCO content of the isocyanate prepolymer, increasing the hard segment content, and combining with the components in the second component, the invention ensures the elasticity of the polymer while improving its mechanical properties, and also improves the electrical insulation and wear resistance of the material.Type: ApplicationFiled: January 22, 2020Publication date: September 17, 2020Applicant: Zhejiang Yuanrong Technology Co., LtdInventors: Songmao YU, Lvming XIAO, Yangang YU, Wanqin ZHANG, Qiwei ZHENG
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Publication number: 20200002381Abstract: A scorpion venom heat-resistant synthetic peptide (SVHRSP) contains an amino acid sequence of SEQ ID NO 1. One or more amino acids the amino acid sequence can be substituted or deleted. A pharmaceutical composition that contains the SVHRSP has numerous applications. The pharmaceutical composition can be used to protect neuronal cell against amyloid beta-induced toxic effects, or to inhibit the sodium channel current of a hippocampal neuronal cell, or to protect a neuronal cell against NMDA-induced injury. It may also promote the formation of a pluripotent neural stem cell from a type II astrocyte, or treats a subject, such as a human, having epilepsy, Alzheimer's disease, or Parkinson's disease.Type: ApplicationFiled: September 17, 2019Publication date: January 2, 2020Inventors: Jie ZHAO, Shao LI, Wanqin ZHANG
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Patent number: 10442837Abstract: A scorpion venom heat-resistant synthetic peptide (SVHRSP) contains an amino acid sequence of SEQ ID NO 1. One or more amino acids the amino acid sequence can be substituted or deleted. A pharmaceutical composition that contains the SVHRSP has numerous applications. The pharmaceutical composition can be used to protect neuronal cell against amyloid beta-induced toxic effects, or to inhibit the sodium channel current of a hippocampal neuronal cell, or to protect a neuronal cell against NMDA-induced injury. It may also promotes the formation of a pluripotent neural stem cell from a type II astrocyte, or treats a subject, such as a human, having epilepsy, Alzheimer's disease, or Parkinson's disease.Type: GrantFiled: November 1, 2017Date of Patent: October 15, 2019Assignee: DALIAN MEDICAL UNIVERSITYInventors: Jie Zhao, Shao Li, Wanqin Zhang
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Publication number: 20180066019Abstract: A scorpion venom heat-resistant synthetic peptide (SVHRSP) contains an amino acid sequence of SEQ ID NO 1. One or more amino acids the amino acid sequence can be substituted or deleted. A pharmaceutical composition that contains the SVHRSP has numerous applications. The pharmaceutical composition can be used to protect neuronal cell against amyloid beta-induced toxic effects, or to inhibit the sodium channel current of a hippocampal neuronal cell, or to protect a neuronal cell against NMDA-induced injury. It may also promotes the formation of a pluripotent neural stem cell from a type II astrocyte, or treats a subject, such as a human, having epilepsy, Alzheimer's disease, or Parkinson's disease.Type: ApplicationFiled: November 1, 2017Publication date: March 8, 2018Inventors: Jie ZHAO, Shao LI, Wanqin ZHANG