Patents by Inventor Warren W. Wakarchuk
Warren W. Wakarchuk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7608442Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.Type: GrantFiled: October 11, 2006Date of Patent: October 27, 2009Assignee: National Research Council of CanadaInventors: Michel Gilbert, Warren W. Wakarchuk
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Publication number: 20090215115Abstract: The present invention provides, e.g., sialyltransferase proteins comprising conserved sequence motifs, including ?-2,3-sialyltransferase proteins from C. jejuni strains O:36 and O:19. The invention also provides methods of making sialylated products using those sialyltransferases.Type: ApplicationFiled: September 16, 2005Publication date: August 27, 2009Applicant: National Research Council of CanadaInventors: Michel Gilbert, Warren W.. Wakarchuk
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Patent number: 7462474Abstract: This invention provides prokaryotic ?1,4-N-acetylgalactosaminyl (GalNAc) transferases involved in synthesis of lipooligosaccharide (LOS). ?1,4-GalNAc transferases are obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the ?1,4-GalNAc transferases, as well as expression vectors and host cells for expressing the ?1,4-GalNAc transferases.Type: GrantFiled: April 8, 2004Date of Patent: December 9, 2008Assignee: National Research Council of CanadaInventors: Michel Gilbert, Warren W. Wakarchuk
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Patent number: 7384771Abstract: This invention provides prokaryotic ?1,4-N-acetylgucosaminyl (GalNAc) transferases involved in synthesis of lipooligosaccharide (LOS). The ?1,4-GalNAc transferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the ?1,4-GalNAc transferases, as well as expression vectors and host cells for expressing the ?1,4-GalNAc transferases.Type: GrantFiled: April 23, 2004Date of Patent: June 10, 2008Assignee: National Research of CanadaInventors: Michel Gilbert, Warren W. Wakarchuk
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Patent number: 7381544Abstract: This invention provides fusion polypeptides that include a glycosyltransferase catalytic domain and a catalytic domain from an accessory enzyme that is involved in making a substrate for a glycosyltransferase reaction. Nucleic acids that encode the fusion polypeptides are also provided, as are host cells for expressing the fusion polypeptides of the invention.Type: GrantFiled: December 11, 2002Date of Patent: June 3, 2008Assignee: National Research Council of CanadaInventors: Michel Gilbert, N. Martin Young, Warren W. Wakarchuk
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Patent number: 7371838Abstract: This invention provides prokaryotic ?1,4-N-acetylglucosaminyl (GalNAc) traosferases involved in synthesis of lipooligosaccharide (LOS). The ?1,4-GalNAc transferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the ?1,4-GaINAc transferases, as well as expression vectors and host cells for expressing the ?1,4-GalNAc transferases.Type: GrantFiled: April 22, 2004Date of Patent: May 13, 2008Assignee: National Research Council of CanadaInventors: Michel Gilbert, Warren W. Wakarchuk
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Patent number: 7259239Abstract: The structure and specificity of a recombinant ?2,3-sialyltransferase from Campylobacter spp., is disclosed. Also provided are methods for using the ?2,3-sialyltransferase in the production of desired carbohydrate structures and nucleic acids that encode the sialyltransferase.Type: GrantFiled: March 11, 2004Date of Patent: August 21, 2007Assignee: National Research Council of CanadaInventors: Michel Gilbert, Warren W. Wakarchuk
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Patent number: 7244601Abstract: This invention provides fusion polypeptides that include a glycosyltransferase catalytic domain and a catalytic domain from an accessory enzyme that is involved in making a substrate for a glycosyltransferase reaction. Nucleic acids that encode the fusion polypeptides are also provided, as are host cells for expressing the fusion polypeptides of the invention.Type: GrantFiled: December 14, 1998Date of Patent: July 17, 2007Assignee: National Research Council of CanadaInventors: Michel Gilbert, N. Martin Young, Warren W. Wakarchuk
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Patent number: 7238509Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.Type: GrantFiled: October 8, 2004Date of Patent: July 3, 2007Assignee: National Research Council of CanadaInventors: Michel Gilbert, Warren W. Wakarchuk
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Patent number: 7220848Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.Type: GrantFiled: May 19, 2004Date of Patent: May 22, 2007Assignee: National Research Council of CanadaInventors: Michel Gilbert, Warren W. Wakarchuk
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Patent number: 7217549Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.Type: GrantFiled: May 21, 2004Date of Patent: May 15, 2007Assignee: National Research Council of CanandaInventors: Michel Gilbert, Warren W. Wakarchuk
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Patent number: 7211657Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.Type: GrantFiled: April 7, 2004Date of Patent: May 1, 2007Assignee: National Research Council of CanadaInventors: Michel Gilbert, Warren W. Wakarchuk
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Patent number: 7208304Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.Type: GrantFiled: May 17, 2004Date of Patent: April 24, 2007Assignee: National Research Council of CanadaInventors: Michel Gilbert, Warren W. Wakarchuk
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Patent number: 7202353Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.Type: GrantFiled: May 14, 2004Date of Patent: April 10, 2007Assignee: National Research Council of CanadaInventors: Michel Gilbert, Warren W. Wakarchuk
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Patent number: 7192756Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.Type: GrantFiled: April 8, 2004Date of Patent: March 20, 2007Assignee: National Research Council of CanadaInventors: Michel Gilbert, Warren W. Wakarchuk
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Patent number: 7189836Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.Type: GrantFiled: October 8, 2004Date of Patent: March 13, 2007Assignee: National Research Council of CanadaInventors: Michel Gilbert, Warren W. Wakarchuk
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Patent number: 7169914Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.Type: GrantFiled: December 11, 2003Date of Patent: January 30, 2007Assignee: National Research Council of CanadaInventors: Michel Gilbert, Warren W. Wakarchuk
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Patent number: 7169593Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.Type: GrantFiled: May 12, 2004Date of Patent: January 30, 2007Assignee: National Research Council of CanadaInventors: Michel Gilbert, Warren W. Wakarchuk
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Patent number: 7166717Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.Type: GrantFiled: May 12, 2004Date of Patent: January 23, 2007Assignee: National Research Council of CanadaInventors: Michel Gilbert, Warren W. Wakarchuk
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Patent number: 7138258Abstract: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an ?2,3- and an ?2,8-activity. A ?1,4-GalNAc transferase and a ?1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter species, including C. jejuni. In additional embodiments, the invention provides nucleic acids that encode the glycosyltransferases, as well as expression vectors and host cells for expressing the glycosyltransferases.Type: GrantFiled: November 21, 2002Date of Patent: November 21, 2006Assignee: National Research Council of CanadaInventors: Michel Gilbert, Warren W. Wakarchuk