Abstract: The invention provides certain (phenyl)-(pyrazol)-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one compounds of formula I as D1 positive allosteric modulators (PAMs), and pharmaceutical compositions thereof. The invention further provides methods of using a compound of formula I, or a pharmaceutically acceptable salt thereof, to treat certain symptoms of Parkinson's disease, schizophrenia, ADHD or Alzheimer's disease.

Abstract: The invention provides certain (phenyl)-(pyrazol)-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one compounds of formula I as D1 positive allosteric modulators (PAMs), and pharmaceutical compositions thereof. The invention further provides methods of using a compound of formula I, or a pharmaceutically acceptable salt thereof, to treat certain symptoms of Parkinson's disease, schizophrenia, ADHD or Alzheimer's disease.

Abstract: The present invention relates to selective allosteric potentiators of the Formula (I): or pharmaceutically acceptable salts thereof, for the treatment of disorders associated with M4 muscarinic receptors.

Abstract: A method of encasing a magnet to isolate the magnet from the environment is provided. The method includes introducing a magnet to a housing having at least one passage capable of passing a fluid from the environment to the magnet, introducing a hardenable fluid, for example, a resin, to the passage to obstruct the passage, and solidifying the hardenable fluid in the passage to provide a solid obstruction to the passage to isolate the magnet from environmental fluids. The housing may be provided as two mating housings and the passage may be provided by the mating surfaces between the two housings. An encased magnet is also disclosed. The encased magnet may be used in any environment that may be damaging to the magnet, for example, in surgical or prosthetic applications.

Abstract: A method of encasing a magnet to isolate the magnet from the environment is provided. The method includes introducing a magnet to a housing having at least one passage capable of passing a fluid from the environment to the magnet, introducing a hardenable fluid, for example, a resin, to the passage to obstruct the passage, and solidifying the hardenable fluid in the passage to provide a solid obstruction to the passage to isolate the magnet from environmental fluids. The housing may be provided as two mating housings and the passage may be provided by the mating surfaces between the two housings. An encased magnet is also disclosed. The encased magnet may be used in any environment that may be damaging to the magnet, for example, in surgical or prosthetic applications.

Abstract: The present invention relates to selective allosteric potentiators of the Formula (I): or pharmaceutically acceptable salts thereof, for the treatment of disorders associated with M4 muscarinic receptors.