Patents by Inventor Wayne R. Curtis

Wayne R. Curtis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quantitative transient protein expression in plant tissue culture
    Patent number: 6740526
    Abstract: The subject invention is related to a method for recombinantly and transiently producing a polypeptide in a plant tissue, which includes providing a plant tissue sample in a bioreactor; adding to the plant tissue sample, a sample of Agrobacterium containing a nucleotide sequence encoding the polypeptide on the T-DNA, co-culturing the plant tissue sample with the Agrobacterium so that the nucleotide sequence is transferred to the plant, allowing the plant tissue to transiently express the polypeptide, and then separating the polypeptide from the mixture.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: May 25, 2004
    Inventor: Wayne R. Curtis
  • Growing cells in a reservoir formed of a flexible sterile plastic liner
    Patent number: 6709862
    Abstract: A method and apparatus for aseptic biological production of cells and/or microorganisms are provided. The apparatus includes a support housing having an interior chamber, a disposable flexible sterile plastic liner lining the interior chamber and a head plate attached to the liner forming a sealed chamber with the liner to form a reservoir. After use the liner can be thrown away and the apparatus can be reused with a new liner. In this way, the apparatus simplifies cleaning and ensuring validation required by pharmaceutical and food industry standards. Aerating fluid is introduced during culturing of cell or microorganisms in the reservoir. A growth characteristic can be used to vary flow rate and/or composition of the aerating fluid. Another reservoir may be used for circulation between two reservoirs.
    Type: Grant
    Filed: June 12, 2001
    Date of Patent: March 23, 2004
    Assignee: The Penn State Research Foundation
    Inventor: Wayne R. Curtis
  • Method and apparatus for aseptic growth of cells and/or microorganisms
    Publication number: 20010031491
    Abstract: A method and apparatus for aseptic biological production of cells and/or microorganisms is provided. The apparatus includes a support housing having an interior chamber, a disposable liner lining the interior chamber and a head plate attached to the liner forming a sealed chamber with the liner. After use the liner can be thrown away and the apparatus can be reused with a new liner. In this way, the apparatus simplifies cleaning and ensuring validation required by pharmaceutical and food industry standards.
    Type: Application
    Filed: June 12, 2001
    Publication date: October 18, 2001
    Inventor: Wayne R. Curtis
  • Method and apparatus for aseptic growth or processing of biomass
    Patent number: 6245555
    Abstract: A method and apparatus for aseptic biological production or processing of cells, tissues and/or microorganisms is provided. The apparatus includes a support housing having an interior chamber, a disposable liner lining the interior chamber and a head plate attached to the liner forming a sealed chamber with the liner. After use the liner can be disposed and the apparatus can be reused with a new liner. In this way, the apparatus simplifies cleaning and ensuring validation required by pharmaceutical and food industry standards.
    Type: Grant
    Filed: September 1, 1999
    Date of Patent: June 12, 2001
    Assignee: The Penn State Research Foundation
    Inventor: Wayne R. Curtis