Patents by Inventor Wayne Sawlivich

Wayne Sawlivich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing polyol-IFN-? conjugate
    Patent number: 7700314
    Abstract: PEG-IFN-? conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-?, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-?.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: April 20, 2010
    Assignee: Merck Serono SA
    Inventors: Nabil El-Tayar, Michael J. Roberts, Milton Harris, Wayne Sawlivich
  • Method for treating disorders and diseases treatable with human fibroblast interferon
    Patent number: 7357925
    Abstract: PEG-IFN-? conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-?, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-?.
    Type: Grant
    Filed: August 28, 2003
    Date of Patent: April 15, 2008
    Assignee: Laboratoires Seronosa
    Inventors: Nabil El-Tayar, Michael J. Roberts, Milton Harris, Wayne Sawlivich
  • POLYOL-IFN-BETA CONJUGATE AND COMPOSITION CONTAINING SAME
    Publication number: 20070141620
    Abstract: PEG-IFN-? conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-?, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-?.
    Type: Application
    Filed: February 13, 2007
    Publication date: June 21, 2007
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Nabil El-Tayar, Michael Roberts, Milton Harris, Wayne Sawlivich
  • Polyol-IFN-beta conjugate and composition containing same
    Publication number: 20040043002
    Abstract: PEG-IFN-&bgr; conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-&bgr;, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-&bgr;.
    Type: Application
    Filed: August 28, 2003
    Publication date: March 4, 2004
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Nabil El-Tayar, Michael J. Roberts, Milton Harris, Wayne Sawlivich
  • Polyol-IFN-&bgr;conjugates modified at Cys-17 and composition containing same
    Patent number: 6638500
    Abstract: PEG-IFN-&bgr; conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-&bgr;, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-&bgr;.
    Type: Grant
    Filed: October 30, 2000
    Date of Patent: October 28, 2003
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Nabil El-Tayar, Michael J. Roberts, Milton Harris, Wayne Sawlivich