Patents by Inventor Wei Ping Gai

Wei Ping Gai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Truncated fragments of alpha-synuclein in Lewy body disease
    Patent number: 7306945
    Abstract: The application identifies fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of alpha-synuclein. The fragments have a truncated C-terminus relative to full-length alpha-synuclein. Some fragments are characterized by a molecular weight of about 12 kDa as determined by SDS gel electrophoresis in tricine buffer and a truncation of at least ten contiguous amino acids from the C-terminus of natural alpha-synuclein. The site of cleavage preferably occurs after residue 117 and before residue 126 of natural alpha-synuclein. The identification of these novel fragments of alpha-synuclein has a number of application in for example, drug discovery, diagnostics, therapeutics, and transgenic animals.
    Type: Grant
    Filed: October 19, 2004
    Date of Patent: December 11, 2007
    Assignees: Elan Pharmaceuticals, Inc., The Trustees of Flinders University
    Inventors: Tamie J Chilcote, Jason Goldstein, John P Anderson, Wei Ping Gai