Abstract: Described herein, inter alia, are compositions of ErbB modulators and methods of using the same.

Abstract: A system and method for magnetic field distortion compensation includes a cryostat for a magnetic resonance imaging (MRI) system. The cryostat includes a vacuum casing having a vacuum therein. A cryogen vessel is disposed within the casing, the vessel having a coolant therein. A thermal shield is disposed between the vacuum casing and the cryogen vessel. An eddy current compensation assembly is disposed within the casing. The eddy current compensation assembly includes a plurality of electrically conductive loops formed on one of the vacuum casing, the cryogen vessel, and the thermal shield and constructed to mitigate vibration-induced eddy currents in the MRI system.

Abstract: Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.

Abstract: Disclosed herein are compounds, compositions, and methods of their use for the treatment of diabetes.

Abstract: The present invention relates to a magnetic field adjustment system for use in a magnetic resonance imaging (MRI) system and a respective method. The magnetic field adjustment system comprises a first magnetic field generating assembly and an additional assembly. Wherein the first magnetic field generating assembly is used for generating a first magnetic field required by the MRI; and the additional assembly, including a switch and a current branch line, is used for cooperating with the first magnetic field generating assembly to generate a second magnetic field required by the MRI.

Abstract: Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.

Abstract: Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.

Abstract: Methods and compositions are provided for extending the half-life of a therapeutic agent. One half-life extending moieties may be attached to a therapeutic agent, thereby extending the half life of the therapeutic agent. The modified therapeutic agents comprising a half-life extending moieties attached to a therapeutic agent may be used to treat a disease or condition in a subject in need thereof.

Abstract: Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.

Abstract: Provided are oxyntomodulin analogs. The peptide analogs have at least two cysteines. The two cysteines are separated by six amino acids such that they can be crosslinked using suitable crosslinking moieties. The crosslinked peptides have long half-lives and/or efficacy. For example, peptide analog compositions are used for inducing weight loss and/or reducing blood glucose levels.

Abstract: A system for energizing a main coil of superconducting magnet in a magnetic resonance imaging (MRI) system includes a cryostat comprising a housing. A first coil is positioned within the housing of the cryostat. Alternatively, the first coil may be positioned external to the housing of the cryostat. A second coil is coupled to the first coil and positioned external to the housing of the cryostat. The second coil is configured to inductively couple to the main coil. A controller is coupled to the first coil and the second coil and is configured to control the first coil and the second coil to induce current in the main coil.

Abstract: A quench protection apparatus includes a number N of superconducting coils and a heater matrix. The number N of superconducting coils are electrically coupled in series. The heater matrix module includes the number N of heater units. The number N of heater units is electrically coupled in parallel with the number N of superconducting coils respectively. A number M of the heater units each includes at least the number N of heaters. Each superconducting coil is thermally coupled with at least one heater of each of the number M of the heater units. The number of N-M of the heater units each includes at least one heater. Each of the number M of superconducting coils correspondingly coupled with the number M of the heater units is thermally coupled with at least one heater of each of the number N-M of the heater units. A superconducting magnet system protected by above quench protection apparatus is also provided.

Abstract: Provided are oxyntomodulin analogs. The peptide analogs have at least two cysteines. The two cysteines are separated by six amino acids such that they can be crosslinked using suitable crosslinking moieties. The crosslinked peptides have long half-lives and/or efficacy. For example, peptide analog compositions are used for inducing weight loss and/or reducing blood glucose levels.

Abstract: Described herein is a method of increasing brown fat differentiation or increasing energy expenditure in a subject in need thereof, the method comprising administering to the subject an LPA receptor modulator, or a pharmaceutically acceptable salt, solvate, polymorph, prodrug, metabolite, deuteride, N-oxide, stereoisomer, or isomer thereof.

Abstract: A superconducting magnet system includes a coil support structure, superconducting coils, and electrically and thermally conductive windings. The superconducting coils and the conductive windings are supported by the coil support structure. Each conductive winding is electromagnetically coupled with a corresponding superconducting coil. Each conductive winding is electrically shorted.

Abstract: The present invention relates to a magnetic field adjustment system for use in a magnetic resonance imaging (MRI) system and a respective method. The magnetic field adjustment system comprises a first magnetic field generating assembly and an additional assembly. Wherein the first magnetic field generating assembly is used for generating a first magnetic field required by the MRI; and the additional assembly, including a switch and a current branch line, is used for cooperating with the first magnetic field generating assembly to generate a second magnetic field required by the MRI.

Abstract: Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.

Abstract: Methods and compositions are provided for extending the half-life of a therapeutic agent. One or more half-life extending moieties may be attached to a therapeutic agent, thereby extending the half life of the therapeutic agent. The modified therapeutic agents (mTAs) comprising one or more half-life extending moieties attached to a therapeutic agent may be used to treat a disease or condition in a subject in need thereof.

Abstract: A system and method for magnetic field distortion compensation includes a cryostat for a magnetic resonance imaging (MRI) system. The cryostat includes a vacuum casing having a vacuum therein. A cryogen vessel is disposed within the casing, the vessel having a coolant therein. A thermal shield is disposed between the vacuum casing and the cryogen vessel. An eddy current compensation assembly is disposed within the casing. The eddy current compensation assembly includes a plurality of electrically conductive loops formed on one of the vacuum casing, the cryogen vessel, and the thermal shield and constructed to mitigate vibration-induced eddy currents in the MRI system.

Abstract: A system and method for magnetic field distortion compensation includes a cryostat for a magnetic resonance imaging (MRI) system. The cryostat includes a vacuum casing having a vacuum therein. A cryogen vessel is disposed within the casing, the vessel having a coolant therein. A thermal shield is disposed between the vacuum casing and the cryogen vessel. An eddy current compensation assembly is disposed within the casing. The eddy current compensation assembly includes a plurality of electrically conductive loops formed on one of the vacuum casing, the cryogen vessel, and the thermal shield and constructed to mitigate vibration-induced eddy currents in the MRI system.