Abstract: Provided are certain compounds or pharmaceutically acceptable salts thereof which can inhibit kinase activity of Bruton's tyrosine kinase (BTK) and may be useful for the treatment of diseases like cancer, immunological disease and inflammation.

Abstract: Embodiments of the present disclosure relate to a new approach for image orientation detection. In the computer-implemented method, at least one character area in an image is sampled. The orientation of the sampled character area is determined, and the orientation of the image is determined based on the determined orientation of the sampled character area.

Abstract: Provided are compound of formula (I) as certain CDK4/6 inhibitors, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: Embodiments of the present disclosure relate to a new approach for image orientation detection. In the computer-implemented method, at least one character area in an image is sampled. The orientation of the sampled character area is determined, and the orientation of the image is determined based on the determined orientation of the sampled character area.

Abstract: Techniques for neural network training are provided. One computer-implemented method comprises: obtaining, by an electronic device operatively coupled to a processing unit, based on a similarity between two images, a first image and a second image. The computer-implemented method also comprises training, by the electronic device, a neural network based on the first image and the second image such that a distance between a first vector and a second vector generated respectively from the first image and the second image in the trained neural network is associated with the similarity.

Abstract: Techniques for model based data processing are proposed. In one example, a computer-implemented method is as follows. A first model is determined from a first category of data processing models and a second model is determined from a second category of data processing models. The second category can be different from the first category in some instances. Performance of a first combined model of the first and second models can be compared with performance of the first model. A target model for processing data can be selected from the first combined model and the first model based on the comparing.

Abstract: Provided are compound of formula (I) as certain CDK4/6 inhibitors, pharmaceutical compositions thereof, and methods of use thereof.

Abstract: A new method for extinguishing fire is provided, characterized in that a pyrotechnic agent is used as a heat source (energy) and a power source (driving gas); during use, the pyrotechnic agent is ignited, and the high temperature generated by the combustion of the pyrotechnic agent is utilized to make a fire extinguishing composition produce a large amount of fire extinguishing substance, which is sprayed out together with the pyrotechnic agent, so as to achieve the purpose of extinguishing a fire. As compared with conventional aerosol fire extinguishing systems, gas fire extinguishing systems and water-based fire extinguishing systems, the fire extinguishing method of the present invention is more efficient and safer.

Abstract: Disclosed herein are protein kinase inhibitors, more particularly novel pyrimidine derivatives and pharmaceutical compositions thereof, and method of use thereof.

Abstract: Disclosed herein are protein kinase inhibitors, more particularly novel pyrimidine derivatives and pharmaceutical compositions thereof, and method of use thereof.

Abstract: Disclosed herein are protein kinase inhibitors, more particularly novel pyrimidine derivatives and pharmaceutical compositions thereof, and method of use thereof.

Abstract: A micro-mixer and use thereof for synthesis of barium sulfate particles is disclosed. The micro-mixer includes feeding tubes, reservoirs, a mixing channel, a buffer reservoir and a sampling tube. The mixing channel is made of hydrophobic materials and processed into a spiral structure, in which baffles are set in interval arrangement at both sides of the channel wall. The types of the baffles include leaning-forward baffles, vertical baffles and leaning-backward baffles. Setting the baffles helps produce local secondary flow in the mixer, which enhances fluids mixing process. The micro-mixer is suitable to rapid reactions or precipitation processes, whose reaction time is much less than mixing time, and has broad application prospects in many fields involving mixing reaction such as pharmaceutical and chemistry industry.

Abstract: A fire extinguishing composition generating fire extinguishing substance through chemical reaction of ingredients at high temperature, wherein: the fire extinguishing composition comprises a flame retardant, an oxidant, a reducing agent and an adhesive; contents of each ingredient are: the flame retardant: 50 wt % to 90 wt %; the oxidant: 5 wt % to 30 wt %; the reducing agent: 5 wt % to 10 wt %; the adhesive: 0% to 10 wt %. In a usage of the fire extinguishing composition, a pyrotechnic agent is adopted as a heat source and a power source; and the purpose of fire extinguishing is achieved by: igniting the pyrotechnic agent, and the oxidant and the reducing agent in the fire extinguishing composition are reacted to generate the in the use of high temperature produced by burning the pyrotechnic agent. by burning the pyrotechnic agent, so as to implement fire extinguishing. Different from the traditional aerosol generating agent, there is no external heat source, and the composition itself does not burn.

Abstract: There is provided a hand-held aerosol fire suppression apparatus, having button, thermal insulating layer, jet nozzle, enclosure of apparatus, combustion chamber, rear fender and rear cap, wherein the enclosure of apparatus has an enclosure of cartridge that accommodate a chemical agent and an enclosure of cooling layer that is filled with a cooling material, the combustion chamber is installed between the enclosure of cartridge and the enclosure of cooling layer, the thermal insulating layer is arranged between the enclosure of apparatus and the enclosure of cartridge, between the enclosure of apparatus and the enclosure of cooling layer, and between the rear fender and the chemical agent. Compared to the prior art, the apparatus has the following advantages: compact in size, suitable for hand-held use, lower temperature at the jet orifice, safe and reliable ignition and operation and long service life.

Abstract: There is provided a hand-held aerosol fire suppression apparatus, having safety pole, button, enclosure of cartridge, enclosure of cooling layer, jet nozzle, tapered jet orifice, enclosure of apparatus, combustion chamber, rear fender, piezoelectric ceramics, rear cap and safety ring; wherein the rear cap is screwed to the enclosure of apparatus; the jet nozzle is screwed or fitted to the enclosure of apparatus; a chemical agent is installed in the enclosure of cartridge and a cooling material is installed in the enclosure of cooling layer in the enclosure of apparatus; a thermal insulating layer is installed between the enclosure of apparatus and the enclosure of cartridge, between the enclosure of apparatus and the enclosure of cooling layer, and between the rear fender and the chemical agent; the combustion chamber is installed between the enclosure or cartridge and the enclosure of cooling layer; a groove is arranged on the enclosure of apparatus to facilitate gripping.

Abstract: The present invention relates to a novel aging-resistant aerosol generating agent and preparation method thereof. The aging-resistant aerosol generating agent in the present invention comprises oxidizer, reducer and bonding agent, wherein the oxidizer is potassium nitrate, the bonding agent is phenolic resin, and the reducer is melamine; the weight percentages of the three constituents are: potassium nitrate: 60˜80%, phenolic resin: 8˜15%, and melamine: the rest. In the preparation process, phenolic resin is dissolved in ethanol to give phenolic resin solution at concentration by 40˜50 wt %; the oxidizer and reducer are pulverized, mixed, and then the phenolic resin solution is added to the mixed powder; next, the mixture is agitated, pelletized, dried, and shaped by pressure molding. Compared to that in the prior art, the aerosol generating agent in the present invention has higher fire suppression efficiency and higher fire suppression rate, and greatly improved aging resistant performance.

Abstract: Disclosed herein are protein kinase inhibitors, more particularly novel pyrimidine derivatives and pharmaceutical compositions thereof, and method of use thereof.

Abstract: A micro-mixer and use thereof for synthesis of barium sulfate particles is disclosed. The micro-mixer includes feeding tubes, reservoirs, a mixing channel, a buffer reservoir and a sampling tube. The mixing channel is made of hydrophobic materials and processed into a spiral structure, in which baffles are set in interval arrangement at both sides of the channel wall. The types of the baffles include leaning-forward baffles, vertical baffles and leaning-backward baffles. Setting the baffles helps produce local secondary flow in the mixer, which enhances fluids mixing process. The micro-mixer is suitable to rapid reactions or precipitation processes, whose reaction time is much less than mixing time, and has broad application prospects in many fields involving mixing reaction such as pharmaceutical and chemistry industry.

Abstract: A fire extinguishing composition generating fire extinguishing substance through chemical reaction of ingredients at high temperature, wherein: the fire extinguishing composition comprises a flame retardant, an oxidant, a reducing agent and an adhesive; contents of each ingredient are: the flame retardant: 50 wt % to 90 wt %; the oxidant: 5 wt % to 30 wt %; the reducing agent: 5 wt % to 10 wt %; the adhesive: 0% to 10 wt %. In a usage of the fire extinguishing composition, a pyrotechnic agent is adopted as a heat source and a power source; and the purpose of fire extinguishing is achieved by: igniting the pyrotechnic agent, and the oxidant and the reducing agent in the fire extinguishing composition are reacted to generate the in the use of high temperature produced by burning the pyrotechnic agent. by burning the pyrotechnic agent, so as to implement fire extinguishing. Different from the traditional aerosol generating agent, there is no external heat source, and the composition itself does not burn.

Abstract: A new method for extinguishing fire is provided, characterized in that a pyrotechnic agent is used as a heat source (energy) and a power source (driving gas); during use, the pyrotechnic agent is ignited, and the high temperature generated by the combustion of the pyrotechnic agent is utilized to make a fire extinguishing composition produce a large amount of fire extinguishing substance, which is sprayed out together with the pyrotechnic agent, so as to achieve the purpose of extinguishing a fire. As compared with conventional aerosol fire extinguishing systems, gas fire extinguishing systems and water-based fire extinguishing systems, the fire extinguishing method of the present invention is more efficient and safer.