Patents by Inventor Weitong Dong

Weitong Dong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INTERMEDIATE COMPOUNDS AND METHODS
    Publication number: 20230183178
    Abstract: The present invention relates to compounds of (II) and an acceptable salt or hydrate thereof method of making same.
    Type: Application
    Filed: February 9, 2023
    Publication date: June 15, 2023
    Inventors: Phouvieng BEYER, Jason A. BRAZZILLO, Magnus ERIKSSON, Jon Charles LORENZ, Laurence J. NUMMY, Sonia RODRIGUEZ, Jolaine SAVOIE, Kanwar Pal Singh SIDHU, Joshua D. SIEBER, Thomas Gabriel TAMPONE, Zhulin TAN, Jun WANG, Li ZHANG, Weitong DONG, Pengtao ZHANG
  • Intermediate compounds and methods
    Patent number: 11603354
    Abstract: The present invention relates to compounds of (II) and an acceptable salt or hydrate thereof method of making same.
    Type: Grant
    Filed: July 14, 2021
    Date of Patent: March 14, 2023
    Inventors: Phouvieng Beyer, Jason A. Brazzillo, Weitong Dong, Magnus Eriksson, Jon Charles Lorenz, Laurence J. Nummy, Sonia Rodriguez, Jolaine Savoie, Kanwar Pal Singh Sidhu, Joshua D. Sieber, Thomas Gabriel Tampone, Zhulin Tan, Jun Wang, Li Zhang, Pengtao Zhang
  • INTERMEDIATE COMPOUNDS AND METHODS
    Publication number: 20210340101
    Abstract: The present invention relates to compounds of (II) and an acceptable salt or hydrate thereof method of making same.
    Type: Application
    Filed: July 14, 2021
    Publication date: November 4, 2021
    Inventors: Phouvieng BEYER, Jason A. BRAZZILLO, Weitong DONG, Magnus ERIKSSON, Jon Charles LORENZ, Laurence J. NUMMY, Sonia RODRIGUEZ, Jolaine SAVOIE, Kanwar Pal Singh SIDHU, Joshua D. SIEBER, Thomas Gabriel TAMPONE, Zhulin TAN, Jun WANG, Li ZHANG, Pengtao ZHANG
  • PROCESSES USEFUL FOR THE PREPARATION OF 1-[3-(4-BROMO-2-METHYL-2H-PYRAZOL-3-YL)-4-METHOXY-PHENYL]-3-(2,4-DIFLUORO-PHENYL)-UREA AND CRYSTALLINE FORMS RELATED THERETO
    Publication number: 20200138784
    Abstract: The present invention is directed to processes and intermediates useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea (Compound I), crystalline forms and solvate forms thereof; and compositions comprising 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea, crystalline forms and solvate forms thereof prepared by processes as described herein.
    Type: Application
    Filed: December 26, 2019
    Publication date: May 7, 2020
    Inventors: Marlon CARLOS, Weitong DONG, Mark MACIAS, Suzanne Michiko SATO, Lee Alani SELVEY
  • Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
    Patent number: 10543193
    Abstract: The present invention is directed to processes and intermediates useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea (Compound I), crystalline forms and solvate forms thereof; and compositions comprising 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea, crystalline forms and solvate forms thereof prepared by processes as described herein.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: January 28, 2020
    Assignee: ARENA PHARMACEUTICALS, INC.
    Inventors: Marlon Carlos, Weitong Dong, Mark Macias, Suzanne Michiko Sato, Lee Alani Selvey
  • Process for the manufacture of 4-aminobenzoamidine dihydrochloride
    Patent number: 10280133
    Abstract: The present invention relates to a process for the preparation of 4-aminobenzoamidine (4-AMBA) salts of general formula (I) preferably the salts thereof with hydrochloric or hydrobromic acid, particularly preferred the dichloride salt.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: May 7, 2019
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Weitong Dong, Christian Wolfgang Hemp, Xiangle Jin, Jun Lu, Ulrich Scholz, Shengmin Su, Wei Xu, Jinsong Yang
  • Process for the preparation of (r)-8-(3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1h-purine-2,6-dione
    Patent number: 10253026
    Abstract: This invention relates to a method for preparation of a xanthine-based compound of formula (I): as well as to intermediates useful in such preparation.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: April 9, 2019
    Assignee: Boenringer Ingelheim International GmbH
    Inventors: Weitong Dong, Yao Huang, Shengmin Su, Yongfen Sun, Pengtao Zhang
  • PROCESSES USEFUL FOR THE PREPARATION OF 1-[3-(4-BROMO-2-METHYL-2H-PYRAZOL-3-YL)-4-METHOXY-PHENYL]-3-(2,4-DIFLUORO-PHENYL)-UREA AND CRYSTALLINE FORMS RELATED THERETO
    Publication number: 20180344698
    Abstract: The present invention is directed to processes and intermediates useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea (Compound I), crystalline forms and solvate forms thereof; and compositions comprising 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea, crystalline forms and solvate forms thereof prepared by processes as described herein.
    Type: Application
    Filed: August 7, 2018
    Publication date: December 6, 2018
    Inventors: Marlon CARLOS, Weitong DONG, Mark MACIAS, Suzanne Suzanne SATO, Lee Alani SELVEY
  • Process for the preparation of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione
    Patent number: 10131618
    Abstract: This invention relates to methods for the synthesis of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione which are useful as intermediates in the manufacture of pharmaceutically active ingredients.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: November 20, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Xiangle Jin, Weitong Dong, Yan Fu, Jun Lu, Le Xie, Wei Xu, Jinsong Yang, Qian Zhu
  • NOVEL PROCESS FOR THE MANUFACTURE OF 4-AMINOBENZOAMIDINE DIHYDROCHLORIDE
    Publication number: 20180319735
    Abstract: The present invention relates to a process for the preparation of 4-aminobenzoamidine (4-AMBA) salts of general formula (I) preferably the salts thereof with hydrochloric or hydrobromic acid, particularly preferred the dichloride salt.
    Type: Application
    Filed: July 6, 2018
    Publication date: November 8, 2018
    Inventors: Weitong DONG, Christian Wolfgang Hemp, Xiangle Jin, Jun Lu, Ulrich Scholz, Shengmin Su, Wei Xu, Jinsong Yang
  • General process for the preparation of 6-substituted or 5,6-disubstituted derivatives of 2-amino-isonicotinic acid
    Patent number: 10106506
    Abstract: This invention relates to a novel synthetic method for the preparation of 6-substituted or 5,6-disubstituted derivatives of 2-amino-isonicotinic acid.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: October 23, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Weitong Dong, Da Deng, Yan Fu, Xiangle Jin, Lidong Xing, Jun Yan
  • Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
    Patent number: 10071075
    Abstract: The present invention is directed to processes and intermediates useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea (Compound I), crystalline forms and solvate forms thereof; and compositions comprising 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea, crystalline forms and solvate forms thereof prepared by processes as described herein.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: September 11, 2018
    Assignee: Arena Pharmaceuticals, Inc.
    Inventors: Marlon Carlos, Weitong Dong, Mark Macias, Suzanne Michiko Sato, Lee Alani Selvey
  • Process for the manufacture of 4-aminobenzoamidine dihydrochloride
    Patent number: 10040750
    Abstract: The present invention relates to a process for the preparation of 4-aminobenzoamidine (4-AMBA) salts of general formula (I) preferably the salts thereof with hydrochloric or hydrobromic acid, particularly preferred the dichloride salt.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: August 7, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Weitong Dong, Christian Wolfgang Hemp, Xiangle Jin, Jun Lu, Ulrich Scholz, Shengmin Su, Wei Xu, Jinsong Yang
  • A GENERAL PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED OR 5,6-DISUBSTITUTED DERIVATIVES OF 2-AMINO-ISONICOTINIC ACID
    Publication number: 20180186741
    Abstract: This invention relates to a novel synthetic method for the preparation of 6-substituted or 5,6-disubstituted derivatives of 2-amino-isonicotinic acid.
    Type: Application
    Filed: July 1, 2016
    Publication date: July 5, 2018
    Inventors: Weitong DONG, Da DENG, Yan FU, Xiangle JIN, Lidong XING, Jun YAN
  • PROCESS FOR THE PREPARATION OF A XANTHINE-BASED COMPOUND
    Publication number: 20180179207
    Abstract: This invention relates to a method for preparation of a xanthine-based compound, as well as to intermediates useful in such preparation.
    Type: Application
    Filed: June 24, 2016
    Publication date: June 28, 2018
    Inventors: Weitong DONG, Yao HUANG, Shengmin SU, Yongfen SUN, Pengtao ZHANG
  • Novel process for the preparation of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione
    Publication number: 20180179142
    Abstract: This invention relates to methods for the synthesis of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione which are useful as intermediates in the manufacture of pharmaceutically active ingredients.
    Type: Application
    Filed: February 26, 2018
    Publication date: June 28, 2018
    Inventors: Xiangle JIN, Weitong DONG, Yan FU, Jun LU, Le XIE, Wei XU, Jinsong YANG, Qian ZHU
  • Process for the preparation of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione
    Patent number: 9938228
    Abstract: This invention relates to methods for the synthesis of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione which are useful as intermediates in the manufacture of pharmaceutically active ingredients.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: April 10, 2018
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Xiangle Jin, Weitong Dong, Yan Fu, Jun Lu, Le Xie, Wei Xu, Jinsong Yang, Qian Zhu
  • PROCESSES USEFUL FOR THE PREPARATION OF 1-[3-(4-BROMO-2-METHYL-2H-PYRAZOL-3-YL)-4-METHOXY-PHENYL]-3-(2,4-DIFLUORO-PHENYL)-UREA AND CRYSTALLINE FORMS RELATED THERETO
    Publication number: 20180072680
    Abstract: The present invention is directed to processes and intermediates useful for the preparation of 1-[3-(4-bromo-2-N methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea (Compound I), crystalline forms and solvate forms thereof; and compositions comprising 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea, crystalline forms and solvate forms thereof prepared by processes as described herein.
    Type: Application
    Filed: August 21, 2017
    Publication date: March 15, 2018
    Inventors: Marlon CARLOS, Weitong DONG, Mark MACIAS, Suzanne Michiko SATO, Lee Alani SELVEY
  • NOVEL PROCESS FOR THE PREPARATION OF SPIRO[2.5]OCTANE-5,7-DIONE AND SPIRO[3.5]NONANE-6,8-DIONE
    Publication number: 20170247315
    Abstract: This invention relates to methods for the synthesis of spiro[2.5]octane-5, 7-dione and spiro[3.5]nonane-6, 8-dione which are useful as intermediates in the manufacture of pharmaceutically active ingredients.
    Type: Application
    Filed: August 28, 2015
    Publication date: August 31, 2017
    Applicant: Boehringer Ingelheim International GMBH
    Inventors: Xiangle XIN, Weitong DONG, Yan FU, Jun LU, Le XIE, Wei XU, Jinsong YANG, Qian ZHU
  • Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
    Patent number: 9745270
    Abstract: The present invention is directed to processes and intermediates useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea (Compound I), crystalline forms and solvate forms thereof; and compositions comprising 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea, crystalline forms and solvate forms thereof prepared by processes as described herein.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: August 29, 2017
    Assignee: Arena Pharmaceuticals, Inc.
    Inventors: Marlon Carlos, Weitong Dong, Mark Macias, Suzanne Michiko Sato, Lee Alani Selvey