Patents by Inventor Weixin Tang
Weixin Tang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240128565Abstract: A battery pack, a vehicle, and an energy storage device are provided. The battery pack includes a cell array and a support member, where the cell array includes a plurality of cells, the cell has a first dimension, and the first dimension is a maximum spacing between two imaginary parallel planes sandwiching the cell; and at least one of the cells 600 mm?first dimension?2500 mm the at least one cell includes a casing and a core located inside the casing, a supporting region is formed on the casing, and the cell is connected to the support member through the supporting region and is supported by the support member. The support member is connected to the supporting region to support the cell.Type: ApplicationFiled: December 28, 2023Publication date: April 18, 2024Applicant: BYD COMPANY LIMITEDInventors: Long HE, Huajun SUN, Wenfeng JIANG, Zhipei LU, Weixin ZHENG, Jianglong TANG, Yan ZHU, Xinyue WANG, Kefeng HE
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Patent number: 11955651Abstract: A power battery pack includes: a pack body; a plurality of cells, disposed in the pack body; the cell having a length L0, a width H0, and a thickness D0, where at least one cell meets: L0>H0?D0, a length direction of the cell is arranged along a width direction of a vehicle body of the electric vehicle, and in the width direction of the electric vehicle, the length L0 of the cell and a size W of the vehicle body of the electric vehicle in the width direction meet: 46%?L0/W?76%; or at least one cell meets: L0>H0?D0, a length direction of the cell is arranged along a length direction of a vehicle body of the electric vehicle, and in the length direction of the electric vehicle, the length L0 of the cell and a size X of the vehicle body of the electric vehicle in the length direction meet: 40%?L0/W?76%.Type: GrantFiled: June 21, 2019Date of Patent: April 9, 2024Assignee: BYD COMPANY LIMITEDInventors: Long He, Huajun Sun, Wenfeng Jiang, Zhipei Lu, Weixin Zheng, Jianglong Tang, Yan Zhu, Xinyue Wang, Kefeng He
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Publication number: 20240018501Abstract: An isolated nucleic acid that includes an open reading frame encoding a lanthipeptide protease polypeptide for scarless tag removal from a polypeptide is presented. Reagents, expression constructs and methods are also provided for preparing a scarless tag polypeptide product from a tagged polypeptide precursor containing a lanthipeptide protease cleavage site. The reagents are directed to novel lanthipeptide proteases and expression constructs and polypeptide precursors that include highly specific lanthipeptide protease substrate recognition sequence. Methods are provided that enable scarless tag removal from a cognate lanthipeptide, a non-cognate lanthipeptide or a heterologous polypeptide that includes extraneous amino acid sequences, such as leader peptides and tags.Type: ApplicationFiled: November 29, 2022Publication date: January 18, 2024Inventors: Wilfred A. van der Donk, Weixin Tang
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Publication number: 20230415175Abstract: A water curtain system with switch, comprising: a main housing, which is integrally formed, comprises a main cavity structure in the middle, a lower part of the main cavity structure is connected to a water inlet pipe part with an inner diameter smaller than that of the main cavity structure, the connecting port between the main cavity structure and the water inlet pipe part is a gate end, an upper part of the main cavity structure is integrally provided with a water outlet base, and an upper part of the water outlet base is provided with an upper cover; a threaded pressing rod, clamped in the main cavity structure above the gate end through a clamping structure, and a lower end of the threaded pressing rod is provided with a water-sealing washer; a pressing rod driver, which drives the threaded pressing rod to rise and fall through threaded cooperation.Type: ApplicationFiled: September 14, 2022Publication date: December 28, 2023Inventors: WEIXIN TANG, ZHIYUAN YUAN, XUEWEN LIU
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Patent number: 11560566Abstract: Some aspects of this disclosure provide compositions, methods, systems, and kits for controlling the activity and/or improving the specificity of RNA-programmable proteins, such as Cas9. For example, provided are guide RNAs (gRNAs) that are engineered to exist in an “on” or “off” state, which control the binding and, in certain instances, cleavage activity of RNA-programmable proteins (e.g., RNA-programmable endonucleases). By incorporating ligand-responsive self-cleaving catalytic RNAs (aptazymes) into guide RNAs, a set of aptazyme-embedded guide RNAs was developed that enable small molecule-controlled nuclease-mediated genome editing and small molecule-controlled base editing, as well as small molecule-dependent transcriptional activation in mammalian cells.Type: GrantFiled: May 11, 2018Date of Patent: January 24, 2023Assignee: President and Fellows of Harvard CollegeInventors: Weixin Tang, Johnny Hao Hu, David R. Liu
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Publication number: 20210363508Abstract: Described herein are compositions, vectors, cells, methods, and kits that provide cell data recorder systems for recording cell states. The cell data recorder systems allow for the recording of both the presence and duration of one or more stimuli in a programmable, reproducible, and multiplexable manner. These cell data recorder systems employ a nucleic acid programmable DNA binding protein, such as a Cas9 nuclease, or a fusion protein comprising a nucleic acid programmable DNA binding domain and a nucleic acid editing domain to introduce recordable changes in the genome of a cell or in a plasmid within the cell.Type: ApplicationFiled: August 22, 2019Publication date: November 25, 2021Inventors: David R. Liu, Weixin Tang
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Publication number: 20200181619Abstract: Some aspects of this disclosure provide compositions, methods, systems, and kits for controlling the activity and/or improving the specificity of RNA-programmable proteins, such as Cas9. For example, provided are guide RNAs (gRNAs) that are engineered to exist in an “on” or “off” state, which control the binding and, in certain instances, cleavage activity of RNA-programmable proteins (e.g., RNA-programmable endonucleases). By incorporating ligand-responsive self-cleaving catalytic RNAs (aptazymes) into guide RNAs, a set of aptazyme-embedded guide RNAs was developed that enable small molecule-controlled nuclease-mediated genome editing and small molecule-controlled base editing, as well as small molecule-dependent transcriptional activation in mammalian cells.Type: ApplicationFiled: May 11, 2018Publication date: June 11, 2020Applicant: President and Fellows of Harvard CollegeInventors: Weixin Tang, Johnny Hao Hu, David R. Liu
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Publication number: 20170240878Abstract: An isolated nucleic acid that includes an open reading frame encoding a lanthipeptide protease polypeptide for scarless tag removal from a polypeptide is presented. Reagents, expression constructs and methods are also provided for preparing a scarless tag polypeptide product from a tagged polypeptide precursor containing a lanthipeptide protease cleavage site. The reagents are directed to novel lanthipeptide proteases and expression constructs and polypeptide precursors that include highly specific lanthipeptide protease substrate recognition sequence. Methods are provided that enable scarless tag removal from a cognate lanthipeptide, a non-cognate lanthipeptide or a heterologous polypeptide that includes extraneous amino acid sequences, such as leader peptides and tags.Type: ApplicationFiled: May 12, 2015Publication date: August 24, 2017Inventors: Wilfred A. van der Donk, Weixin Tang
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Patent number: 9326523Abstract: The disclosure provides lantibiotics geobacillin I and geobacillin II from Geobacillus thermodenitrificans, compositions comprising the lantibiotics, and methods of use of the lantibiotics. Further disclosed are the sequences of lantibiotics geobacillin I and geobacillin I, and alternative structures of geobacillin I and geobacillin II comprising amino acid substitutions. Antimicrobial compositions comprising one or more isolated geobacillins and a pharmaceutically acceptable carrier, and methods of reducing reproduction of bacteria comprising administering to a subject a therapeutically effective amount of the antimicrobial composition are also provided.Type: GrantFiled: February 7, 2013Date of Patent: May 3, 2016Assignee: The Board of Trustees of the University of IllinoisInventors: Wilfred A. van der Donk, Neha Garg, Yuki Goto, Weixin Tang
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Publication number: 20150050256Abstract: The invention provides lantibiotics geobacillin I and geobacillin II from Geobacillus thermodenitrificans, compositions comprising the lantibiotics, and methods of use of the lantibiotics.Type: ApplicationFiled: February 7, 2013Publication date: February 19, 2015Applicant: The Board of Trustees of the University of IllinoisInventors: Wilfred A. van der Donk, Neha Garg, Yuki Goto, Weixin Tang
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Patent number: 5795470Abstract: A magnetic separation apparatus is disclosed herein. The apparatus includes a flow-through vessel defining a plenum and an inlet port for introducing fluid into the plenum. A hydrodynamic damping structure is provided between the inlet port and plenum for reducing turbulence in the fluid. A mounting device is provided with a slot therein for supporting and receiving the vessel. The mounting device also supports a first array of magnets along one side of the slot and arranged adjacent one another to face the slot with alternating polarity, and a second array of magnets along the opposite side of the slot from the first array arranged adjacent one another to face the slot with alternating polarity and confronting and magnetically opposing the magnets in the first array.Type: GrantFiled: June 7, 1995Date of Patent: August 18, 1998Assignee: Immunivest CorporationInventors: Yuzhou Wang, Weixin Tang, Paul A. Liberti
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Patent number: 5541072Abstract: Methods and devices are provided for separation of magnetic particles and/or magnetic-associated substances from non-magnetic associated substances and media. The methods are specifically applicable to biological separation, and utilize a phase phenomenon arising from mutual interactions between suspended magnetic particles and interactions with the suspension medium. The phenomenon is exploited to produce and maintain a distinct, structured phase of magnetic particles, or ferrophase, within a multi-phase liquid system. A ferrophase is established within a separation chamber prior to introducing therein a test sample containing the target substances to be separated. The formation of a ferrophase is used to transport target substances from regions of relatively low magnetic field gradient to regions of relatively high magnetic field gradient within a high-gradient magnetic separation apparatus.Type: GrantFiled: April 18, 1994Date of Patent: July 30, 1996Assignee: Immunivest CorporationInventors: Yuzhou Wang, Weixin Tang, William J. Cronin, Paul A. Liberti
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Patent number: 5466574Abstract: A magnetic separator for isolating magnetically-labeled substances of interest, such as immunological agents, from a non-magnetic test medium using a method of high gradient magnetic separation. The target substance is contacted with microscopic magnetic particles having a receptor for binding with the target substance. The test medium containing the magnetic particles is held in a non-magnetic container and placed into a gap within an arrangement of magnets for causing the magnetic particles to adhere to selected locations upon the interior wall of the container. The quantity of magnetic particles may be controlled to cause the magnetic particles collected upon the interior wall to form a monolayer. The magnets are arranged upon a yoke which may provide linear, surrounding multipolar, or partially surrounding multipolar configurations of magnetic pole faces about the gap.Type: GrantFiled: January 15, 1993Date of Patent: November 14, 1995Assignee: Immunivest CorporationInventors: Paul A. Liberti, Yuzhou Wang, Weixin Tang, Brian P. Feeley, Dhanesh I. Gohel