Patents by Inventor Weixin Zhao
Weixin Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230372637Abstract: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.Type: ApplicationFiled: August 3, 2023Publication date: November 23, 2023Inventors: James J. Yoo, Anthony Atala, Kyle W. Binder, Mohammad Z. Albanna, Weixin Zhao, Dennis Dice, Tao Xu
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Patent number: 11759579Abstract: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.Type: GrantFiled: November 26, 2019Date of Patent: September 19, 2023Assignee: Wake Forest University Health SciencesInventors: James J. Yoo, Anthony Atala, Kyle W. Binder, Mohammad Z. Albanna, Weixin Zhao, Dennis Dice, Tao Xu
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Publication number: 20200238024Abstract: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.Type: ApplicationFiled: November 26, 2019Publication date: July 30, 2020Inventors: James J. Yoo, Anthony Atala, Kyle W. Binder, Mohammad Z. Albanna, Weixin Zhao, Dennis Dice, Tao Xu
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Publication number: 20200101273Abstract: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data useful to create a map of a bodily surface; and (b) a printer operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the bodily surface based upon the data or map. Methods of forming a tissue on a bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing bodily surface data.Type: ApplicationFiled: November 25, 2019Publication date: April 2, 2020Inventors: James J. Yoo, Anthony Atala, Kyle W. Binder, Weixin Zhao, Dennis Dice, Tao Xu
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Patent number: 10537689Abstract: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.Type: GrantFiled: October 12, 2018Date of Patent: January 21, 2020Assignee: Wake Forest University Health SciencesInventors: James J. Yoo, Anthony Atala, Kyle W. Binder, Mohammad Z. Albanna, Weixin Zhao, Dennis Dice, Tao Xu
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Patent number: 10500384Abstract: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data useful to create a map of a bodily surface; and (b) a printer operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the bodily surface based upon the data or map. Methods of forming a tissue on a bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing bodily surface data.Type: GrantFiled: January 7, 2011Date of Patent: December 10, 2019Assignee: Wake Forest University Health SciencesInventors: James J. Yoo, Anthony Atala, Kyle W. Binder, Weixin Zhao, Dennis Dice, Tao Xu
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Patent number: 10337018Abstract: The present disclosure discloses an asparaginase mutant with efficient expression, activity and stability, belonging to the technical fields of gene engineering and enzyme engineering. The amino acid sequence of the asparaginase mutant is set forth in SEQ ID NO: 99, SEQ ID NO: 100 or SEQ ID NO: 101; meanwhile, compared with the wild type asparaginase mutant, the extracellular enzyme activity of the asparaginase fusion enzyme mutant is increased by up to 2.25 times, the stability is increased by up to 3.56 times, and the specific enzyme activity is increased by up to 1.34 times.Type: GrantFiled: November 1, 2018Date of Patent: July 2, 2019Assignee: JIANGNAN UNIVERSITYInventors: Song Liu, Jian Chen, Guocheng Du, Weixin Zhao
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Patent number: 10273266Abstract: The present invention relates to a multi-functional peptide benefiting expression, purification, stabilization and catalytic efficiency of recombinant proteins, which relates to the field of enzyme engineering and protein purification. The present invention provides a self-assembling amphipathic peptide, which fused with proteins including alkaline polygalacturonate lyase (PGL), lipoxygenase (LOX) and green fluorescent protein (GFP), which leads to successful purification by the nickel affinity chromatography with recovery rates were 47.01%, 39.01% and 56.1%, respectively. Furthermore, the expression quantity and thermostability of the three proteins were enhanced in different degree. Of which the half-life of the PGL-S1v1 and LOX-S1v1 were 2.3 and 3.8-fold as compared with the corresponding wild-type and the specific activity were 1.1 and 1.9-fold increase, respectively. The crude enzyme activity of PGL-S1v1 was 9-fold increase than the PGL.Type: GrantFiled: July 24, 2017Date of Patent: April 30, 2019Assignee: JIANGNAN UNIVERSITYInventors: Song Liu, Weixin Zhao, Jian Chen, Guocheng Du
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Publication number: 20190038849Abstract: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.Type: ApplicationFiled: October 12, 2018Publication date: February 7, 2019Inventors: James J. Yoo, Anthony Atala, Kyle W. Binder, Mohammad Z. Albanna, Weixin Zhao, Dennis Dice, Tao Xu
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Patent number: 10118005Abstract: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.Type: GrantFiled: September 6, 2013Date of Patent: November 6, 2018Assignee: WAKE FOREST UNIVERSITY HEALTH SCIENCESInventors: James J. Yoo, Anthony Atala, Kyle W. Binder, Mohammad Z. Albanna, Weixin Zhao, Dennis Dice, Tao Xu
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Publication number: 20180298058Abstract: The present invention relates to a multi-functional peptide benefiting expression, purification, stabilization and catalytic efficiency of recombinant proteins, which relates to the field of enzyme engineering and protein purification. The present invention provides a self-assembling amphipathic peptide, which fused with proteins including alkaline polygalacturonate lyase (PGL), lipoxygenase (LOX) and green fluorescent protein (GFP), which leads to successful purification by the nickel affinity chromatography with recovery rates were 47.01%, 39.01% and 56.1%, respectively. Furthermore, the expression quantity and thermostability of the three proteins were enhanced in different degree. Of which the half-life of the PGL-S1v1 and LOX-S1v1 were 2.3 and 3.8-fold as compared with the corresponding wild-type and the specific activity were 1.1 and 1.9-fold increase, respectively. The crude enzyme activity of PGL-S1v1 was 9-fold increase than the PGL.Type: ApplicationFiled: July 24, 2017Publication date: October 18, 2018Inventors: Song Liu, Weixin Zhao, Jian Chen, Guocheng DU
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Patent number: 8917384Abstract: A portable optical sensor for measuring surface strain in an object, such as pre-stressed concrete articles, is provided. The sensor is a modular device comprising at least first and second modules, each of which includes a laser and image sensor. When placed adjacent to the object, the laser of each module illuminates respective, spaced-apart areas of the object's surface and each module's image sensor captures at least a portion of the light reflected from the illuminated area and generates a speckle image of the area. Speckle images of the areas taken at various times and/or under various object stress conditions are compared to arrive at a surface strain measurement for the object.Type: GrantFiled: March 21, 2013Date of Patent: December 23, 2014Assignee: Kansas State University Research FoundationInventors: Weixin Zhao, Burdette Terry Beck, Robert Peterman, Chih-Hang Wu
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Publication number: 20140012225Abstract: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data to create a map of a patient bodily surface; and (b) a dispenser operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the patient bodily surface based upon the data or map. Methods of forming a tissue on a patient bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing patient bodily surface data.Type: ApplicationFiled: September 6, 2013Publication date: January 9, 2014Applicant: Wake Forest University Health SciencesInventors: James J. Yoo, Anthony Atala, Kyle W. Binder, Mohammad Z. Albanna, Weixin Zhao, Dennis Dice, Tao Xu
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Publication number: 20130250278Abstract: A portable optical sensor for measuring surface strain in an object, such as pre-stressed concrete articles, is provided. The sensor is a modular device comprising at least first and second modules, each of which includes a laser and image sensor. When placed adjacent to the object, the laser of each module illuminates respective, spaced-apart areas of the object's surface and each module's image sensor captures at least a portion of the light reflected from the illuminated area and generates a speckle image of the area. Speckle images of the areas taken at various times and/or under various object stress conditions are compared to arrive at a surface strain measurement for the object.Type: ApplicationFiled: March 21, 2013Publication date: September 26, 2013Inventors: Weixin Zhao, Burdette Terry Beck, Robert Peterman, Chih-Hang Wu
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Publication number: 20110172611Abstract: Provided herein is a delivery system, including: (a) an optical sensor configured to detect data useful to create a map of a bodily surface; and (b) a printer operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the bodily surface based upon the data or map. Methods of forming a tissue on a bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing bodily surface data.Type: ApplicationFiled: January 7, 2011Publication date: July 14, 2011Inventors: James J. Yoo, Anthony Atala, Kyle W. Binder, Weixin Zhao, Dennis Dice, Tao Xu
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Patent number: D1012869Type: GrantFiled: December 16, 2021Date of Patent: January 30, 2024Inventor: Weixin Zhao
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Patent number: D1017004Type: GrantFiled: May 4, 2022Date of Patent: March 5, 2024Inventor: Weixin Zhao
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Patent number: D1019737Type: GrantFiled: May 4, 2022Date of Patent: March 26, 2024Inventor: Weixin Zhao