Abstract: An integrated circuit (IC) structure includes a semiconductor substrate, a first gate line, a second gate line, and a first auxiliary gate portion. The semiconductor substrate comprises a semiconductor fin. The semiconductor fin extends substantially along a first direction. The first gate line and the second gate line extend substantially along a second direction different form the first direction from a top view. The first auxiliary gate portion connects the first gate line to the second gate line from the top view.

Abstract: Antibodies, antigen-binding fragments and polypeptides that bind to HER2 are disclosed, as well as nucleic acids and vectors encoding the same. Also provided are cells comprising the antibodies, antigen-binding fragments, polypeptides, nucleic acids and vectors, methods of making such molecules, and the use of such molecules for therapeutic applications.

Abstract: A transmission interface between at least a first module and a second module is proposed. The transmission interface includes at least two physical transmission mediums. Each physical transmission medium is arranged to carry a multiplexed signal in which at least two signals are integrated. The at least two physical transmission mediums include a first physical transmission medium arranged to carry a first multiplexed signal including a first IF signal and a reference clock signal. The first IF signal and the reference clock signal are at different frequencies.

Abstract: We describe an antibody or antigen-binding fragment thereof comprising a heavy chain variable region (VH) sequence and a light chain variable region (VL) sequence of a clone selected from: 5C4, 4H1, 1D2, 1C4, 2B5, 1F1, 1H1, 4A5, 1D8, 1D3, 2F1, 3C6, 3D12, 3A9, 1F4, 1H10, 3C12, 4G11, 4A12, 1A12, 3G12, 4F9, 4G4 and 1E1 which is capable of specifically binding to glypican-3 (GPC-3) (GenBank Accession Number: NP_004475.1), or a sequence having at least 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% sequence identity thereto.

Abstract: Antibodies, antigen-binding fragments and polypeptides that bind to HER2 are disclosed, as well as nucleic acids and vectors encoding the same. Also provided are cells comprising the antibodies, antigen-binding fragments, polypeptides, nucleic acids and vectors, methods of making such molecules, and the use of such molecules for therapeutic applications.

Abstract: Methods and compositions for treatment and therapy of cancer are provided. Specifically, antagonists specific for interleukin-17 receptor B (IL-17RB) and its ligand IL-17B are provided. Potent neutralizing antibodies specific for IL-17RB and methods for their manufacture and use are disclosed. The invention also relates to antisense, RNAi and shRNA compositions for the prevention and treatment of cancer, in particular breast cancer and pancreatic cancer.

Abstract: Antibodies and fragments thereof which bind to peptide-MHC complexes are described. In particular, an antibody binding to a peptide-MHC complex comprising a peptide of p53 and a MHC Class I molecule comprising ?-chain encoded by an HLA-A*24 allele is claimed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods of treating, preventing and diagnosing cancers using the same.

Abstract: Methods and compositions for treatment and therapy of cancer are provided. Specifically, antagonists specific for interleukin-17 receptor B (IL-17RB) and its ligand IL-17B are provided. Potent neutralizing antibodies specific for IL-17RB and methods for their manufacture and use are disclosed. The invention also relates to antisense, RNAi and shRNA compositions for the prevention and treatment of cancer, in particular breast cancer and pancreatic cancer.

Abstract: Method and software architecture for providing data-change alerts corresponding to data changes in a data system to external (of the data system) applications. A computer user interface is provided to enable a user to identify user interface (UI) objects corresponding to a user interface of an application used to access the data system to provide data-change alert support for. For example, the UI objects may comprise screens, views, applets, fields, and columns. Based on the alert-enabled UI objects, data-change alert triggers are generated to monitor for data-change events (e.g., inserts, updates, and deletes) that cause changes to data in the data system corresponding to those alert-enabled UI objects. In response to data changes in the data system corresponding to alert-enabled UI objects, appropriate triggers are executed to initiate generation of data-change alerts comprising data values that have been changed. The data-change alerts are then pushed to the external application.

Abstract: A method and system for building/updating grammars in voice access systems is disclosed. The method includes receiving a grammar update request from a voice access system, retrieving data, filtering the data and providing the filtered data to the voice access system. The grammar update request identifies a navigation context of a user interface provided by a data system. The user interface provides access to information in the data system. The data is retrieved from the data system and pertains to the navigation context. The filtering is performed to obtain filtered data pertaining to user interface (UI) objects enabled for grammar updates.

Abstract: Method and System to update grammar information in a voice access system that provides access to a data system. A user interface (UI) is provided to enable an administrator to select UI object pertaining to a user interface provided by the data system to provide grammar update support for. The data system user interface corresponds to a UI that users would see if using computer client connection to the data system. XSLT style sheets are built based on the UI objects that are selected for grammar update. A grammar update request may then submitted that identifies a navigation context of the data system UI, a style sheet to apply, and an optional last update value. In response to receiving the request, the system retrieves data from the data system pertaining to the navigation context; and filters the data using the identified style sheet and the last update value and provides the filtered data back to the voice access system to update its grammar.

Abstract: Method and System to update grammar information in a voice access system that provides access to a data system. A user interface (UI) is provided to enable an administrator to select UI object pertaining to a user interface provided by the data system to provide grammar update support for. The data system user interface corresponds to a UI that users would see if using computer client connection to the data system. XSLT style sheets are built based on the UI objects that are selected for grammar update. A grammar update request may then submitted that identifies a navigation context of the data system UI, a style sheet to apply, and an optional last update value. In response to receiving the request, the system retrieves data from the data system pertaining to the navigation context; and filters the data using the identified style sheet and the last update value and provides the filtered data back to the voice access system to update its grammar.

Abstract: A method and system that provides filtered data from a data system. In one embodiment the system includes an API (application programming interface) and associated software modules to enable third party applications to access an enterprise data system. Administrators are enabled to select specific user interface (UI) objects, such as screens, views, applets, columns and fields to voice or pass-through enable via a GUI that presents a tree depicting a hierarchy of the UI objects within a user interface of an application. An XSLT style sheet is then automatically generated to filter out data pertaining to UI objects that were not voice or pass-through enabled. In response to a request for data, unfiltered data are retrieved from the data system and a specified style sheet is applied to the unfiltered data to return filtered data pertaining to only those fields and columns that are voice or pass-through enabled.

Abstract: Method and software architecture for providing data-change alerts corresponding to data changes in a data system to external (of the data system) applications. A computer user interface is provided to enable a user to identify user interface (UI) objects corresponding to a user interface of an application used to access the data system to provide data-change alert support for. For example, the UI objects may comprise screens, views, applets, fields, and columns. Based on the alert-enabled UI objects, data-change alert triggers are generated to monitor for data-change events (e.g., inserts, updates, and deletes) that cause changes to data in the data system corresponding to those alert-enabled UI objects. In response to data changes in the data system corresponding to alert-enabled UI objects, appropriate triggers are executed to initiate generation of data-change alerts comprising data values that have been changed. The data-change alerts are then pushed to the external application.

Abstract: A method and system that provides filtered data from a data system. In one embodiment the system includes an API (application programming interface) and associated software modules to enable third party applications to access an enterprise data system. Administrators are enabled to select specific user interface (UI) objects, such as screens, views, applets, columns and fields to voice or pass-through enable via a GUI that presents a tree depicting a hierarchy of the UI objects within a user interface of an application. An XSLT style sheet is then automatically generated to filter out data pertaining to UI objects that were not voice or pass-through enabled. In response to a request for data, unfiltered data are retrieved from the data system and a specified style sheet is applied to the unfiltered data to return filtered data pertaining to only those fields and columns that are voice or pass-through enabled.

Abstract: A cork screw which comprises a pedestal and a rotary handle incorporating a stem and a penetrating screw wherein the pedestal incorporates a dog member to engage with a helical groove of the stem and a spring biased sleeve around the stem to cause the dog member to engage with the helical groove when the handle is turned in a certain direction and disengage therefrom when a cork is pulled entirely out of a bottle. A holding member is incorporated in the pedestal to hold a cork after it has been pulled out of a bottle.

Abstract: A can opener includes an operating rotary handle body incorporating a rotary serrated clamping head to clamp a projecting edge joint of a can against a cutting disc. The clamping head is mounted on an eccentric shaft which is driven by a central shaft of the handle body through gears in which the driven gear incorporates a means for moving axially the clamping head to a clamping position. Upon rotation of the handle body, the clamping head clamps a projecting edge joint of a can against the cutting disc, and the cutting disc severs the edge joint.

Abstract: A cork screw which has a screw stem with a rotary handle incorporating a penetrating screw, and a hollow pedestal to be seated on a bottle sleeved movably on the stem and encasing the penetrating screw. Dog members are fulcrumed on the pedestal and engage releaseably with a helical groove of the screw stem. Upon rotation of the handle, the penetrating screw penetrates into the cork and subsequently pulls out the cork from the bottle.

Abstract: An improved cork screw which comprises a rotary handle and a cork penetrating spiral member encased in an upper hollow shank and a lower bell-shaped pedestal which can be seated on a bottle. A cork pulling lever is attached to the top of the spiral member and threaded through two diametrically opposite longitudinal apertures provided in the wall of the hollow shank. It is separably fitted to the bottom side of the handle and movable upward or downward along the longitudinal apertures. When the cork is to be pulled out, the user may hold the handle with his one hand and pull the lever towards the handle with his two fingers, thereby facilitating the cork's removal.