Patents by Inventor Wenbin Lin
Wenbin Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240134156Abstract: The present invention provides an optical imaging lens. The optical imaging lens comprises eight lens elements positioned in an order from an object side to an image side. Through controlling convex or concave shape of surfaces of the lens elements and satisfying at least one inequality, the optical imaging lens may shorten system length with a good imaging quality.Type: ApplicationFiled: June 7, 2023Publication date: April 25, 2024Applicant: Genius Electronic Optical (Xiamen) Co., Ltd.Inventors: CHUANBO DONG, WENBIN LIN, QINGZHI ZHU
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Publication number: 20240126047Abstract: The present invention provides an optical imaging lens. The optical imaging lens comprises seven lens elements positioned in an order from an object side to an image side. Through controlling the convex or concave shape of the surfaces of the lens elements, the optical imaging lens may shorten system length and enlarge field of view and aperture size.Type: ApplicationFiled: July 10, 2023Publication date: April 18, 2024Applicant: Genius Electronic Optical (Xiamen) Co., Ltd.Inventors: Huabin Liao, Wenbin Lin, Jiali Lian, Ou Zhou
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Publication number: 20240042045Abstract: Prodrugs that target the low-density lipoprotein receptor (LDLR) and that comprise acid and/or enzyme cleavable acetal- or oxybenzyloxy-linked carbonate or carbamate bonds are described. Also described are core-shell nanoparticles comprising metal-organic framework cores or nanoscale metal bisphosphate coordination polymer cores, and lipid coating layers containing the prodrugs. The nanoparticle core can optionally contain one or more hydrophilic chemotherapeutic agents. The prodrugs and nanoparticles can be used in methods of treating cancer. For instance, the presently disclosed nanoparticles can be used for the co-delivery of multiple chemotherapeutic agents in methods providing increased accumulation of chemotherapeutic agents to a tumor compared to delivery of mixtures of free chemotherapeutic agents.Type: ApplicationFiled: August 23, 2021Publication date: February 8, 2024Inventors: Wenbin Lin, Xiaomin Jiang, Wenbo Han, Xuanyu Feng
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Patent number: 11872311Abstract: Metal-bisphosphonate nanoparticles are disclosed. Also disclosed are pharmaceutical compositions including the metal-bisphosphonate nanoparticles, methods of preparing the metal-bisphosphonate nanoparticles and materials comprising the nanoparticles, and methods of using the compositions to treat cancer or bone-related disorders (e.g., bone-resorption-related diseases, osteoporosis, Paget's disease, and bone metastases) and as imaging agents.Type: GrantFiled: February 25, 2020Date of Patent: January 16, 2024Assignee: The University of North Carolina at Chapel HillInventors: Wenbin Lin, Demin Liu, Joseph Della Rocca, Stephanie Kramer, Christopher Y. Poon
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Publication number: 20240000741Abstract: Methods of treating cancer comprising the use of combinations of a retinoid, e.g., all-trans retinoic acid (ATRA), and radiotherapy are described. The administration of a retinoid can enhance the effect of radiotherapy, including enhancing fractionated, low-dose radiotherapy. Use of the combination increases tumor necrosis factor alpha (TNF-?)- and inducible nitric oxide synthase (iNOS)-producing inflammatory macrophages in local (radiated) and distal (non-radiated) tumors. The methods can optionally further involve the use of checkpoint blockade immunotherapy.Type: ApplicationFiled: June 5, 2023Publication date: January 4, 2024Inventors: Wenbin Lin, Ralph R. Weichselbaum, Hua Liang, Yingying Li
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Patent number: 11826426Abstract: Metal-organic layers (MOLs) and metal-organic nanoplates (MOPs) comprising photosensitizers are described. The MOLs and MOPs can also include moieties capable of absorbing X-rays or other ionizing irradiation energy and/or scintillation. Optionally, the photo sensitizer or a derivative thereof can form a bridging ligand of the MOL or MOP. Also described are methods of using MOLs and MOPs in photodynamic therapy, X-ray induced photodynamic therapy (X-PDT), radiotherapy (RT), radiodynamic therapy, or in radiotherapy-radiodynamic therapy (RT-RDT), either with or without the co-administration of another therapeutic agent, such as a chemotherapeutic agent or an immunomodulator.Type: GrantFiled: August 2, 2018Date of Patent: November 28, 2023Assignee: The University of ChicagoInventors: Wenbin Lin, Kaiyuan Ni, Guangxu Lan
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Publication number: 20230293698Abstract: Modified metal-organic framework (MOFs) are described that have surfaces with enhanced ability to coordinatively bond to or electrostatically interact with therapeutic agents, such as nucleic acids and small molecules and proteins with phosphate or carboxylate groups. Methods of providing the modified MOFs are described that include replacing strongly coordinating metal oxo cluster capping groups with weakly coordinating capping groups and/or incorporating organic bridging ligands with electron-withdrawing groups. MOFs with surface attached therapeutic agents (e.g., immunotherapeutic agents) prepared from the modified MOFs are also described, along with methods of using the MOFs as to treat cancer, e.g., via radiotherapy-radiodynamic therapy (RT-RDT), either with or without the co-administration of another therapeutic agent, such as a chemotherapeutic agent or an immunomodulator. Thus, the described methods can involve cancer immunotherapy and in situ cancer vaccination.Type: ApplicationFiled: May 24, 2021Publication date: September 21, 2023Inventors: Wenbin Lin, Kaiyuan Ni, Taokun Luo, Guangxu Lan
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Patent number: 11740434Abstract: The present invention provides an optical imaging lens. The optical imaging lens comprises seven lens elements positioned in an order from an object side to an image side. Through controlling the convex or concave shape of the surfaces of the lens elements, the optical imaging lens may shorten system length and enlarge field of view and aperture size.Type: GrantFiled: June 4, 2020Date of Patent: August 29, 2023Assignee: Genius Electronic Optical (Xiamen) Co., Ltd.Inventors: Huabin Liao, Wenbin Lin, Jiali Lian, Ou Zhou
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Patent number: 11709339Abstract: The present invention provides an optical imaging lens. The optical imaging lens comprises eight lens elements positioned in an order from an object side to an image side. Through controlling convex or concave shape of surfaces of the lens elements, the optical imaging lens may shorten system length with a good imaging quality.Type: GrantFiled: March 17, 2020Date of Patent: July 25, 2023Assignee: Genius Electronic Optical (Xiamen) Co., Ltd.Inventors: Chuanbo Dong, Wenbin Lin, Qingzhi Zhu
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Patent number: 11673125Abstract: Surface hydroxyl groups on porous and nonporous metal oxides, such as silica gel and alumina, were metalated with catalyst precursors, such as complexes of earth abundant metals (e.g., Fe, Co, Cr, Ni, Cu, Mn and Mg). The metalated metal oxide catalysts provide a versatile family of recyclable and reusable single-site solid catalysts for catalyzing a variety of organic transformations. The catalysts can also be integrated into a flow reactor or a supercritical fluid reactor.Type: GrantFiled: August 18, 2017Date of Patent: June 13, 2023Assignee: The University of ChicagoInventors: Wenbin Lin, Kuntal Manna, Pengfei Ji, Takahiro Sawano, Zekai Lin
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Publication number: 20230036839Abstract: Nanoparticles comprising micheliolide (MCL) or derivatives thereof, and optionally additional therapeutic agents, such as chemotherapeutic agents, are described. Also described are methods of treating diseases, such as cancer, comprising the use of combinations of MCL or a derivative thereof with X-ray irradiation and/or other therapeutic agents, such as immune checkpoint inhibitors. The use of the combinations can provide synergistic anticancer therapeutic efficacy, for example, as the MCL or derivative thereof can both sensitize cancer cells to therapy and target resistant cancer stem cells (CSCs) for selective cell death.Type: ApplicationFiled: June 30, 2022Publication date: February 2, 2023Applicant: The University of ChicagoInventors: Wenbin Lin, Christina Chan, Wenbo Han
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Patent number: 11555985Abstract: An optical imaging lens may include a first, a second, a third, a fourth, a fifth and a sixth lens elements positioned in an order from an object side to an image side. The optical imaging lens may satisfy AAG/(T3+T6)?2.500, wherein a sum of five air gaps from the first lens element to the sixth lens element along the optical axis is represented by AAG, a thickness of the third lens element along the optical axis is represented by T3, and a thickness of the sixth lens element along the optical axis is represented by T6.Type: GrantFiled: December 17, 2020Date of Patent: January 17, 2023Assignee: Genius Electronic Optical (Xiamen) Co., Ltd.Inventors: Hung Chien Hsieh, Wenbin Lin, Xinming Liu
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Patent number: 11460677Abstract: An optical imaging lens includes a first lens element to a seventh lens element, and each lens element has an object-side surface and an image-side surface. The second lens element has negative refracting power, a periphery region of the object-side surface of the third lens element is concave, an optical axis region of the image-side surface of the third lens element is convex, the fifth lens element has positive refracting power, an optical axis region of the image-side surface of the fifth lens element is convex, an optical axis region of the image-side surface of the sixth lens element is concave, an optical axis region of the image-side surface of the seventh lens element is concave, a periphery region of the image-side surface of the seventh lens element is convex. The optical imaging lens satisfies the following conditions: D11t42/AAG37?1.700 and D11t31/G34?12.000.Type: GrantFiled: February 26, 2020Date of Patent: October 4, 2022Assignee: Genius Electronic Optical (Xiamen) Co., Ltd.Inventors: Jiayuan Zhang, Hai Lin, Wenbin Lin
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Patent number: 11419192Abstract: A lighting apparatus includes a light source, a detector and a driver. The light source includes a first set of LED modules and a second set of LED modules. The first set of LED modules and the second set of LED modules emit lights with different color temperatures. The detector is used for detecting an operation pattern corresponding to one of a plurality of operation modes. The operation pattern is transmitted from an operation on a wall switch electrically connected to the lighting apparatus. The driver generates a first current to the first set of LED modules and a second current to the second set of LED modules based on the operation mode associated with the detected operation pattern. The operation mode corresponding to both a corresponding luminance level and a corresponding color temperature at the same time.Type: GrantFiled: April 13, 2020Date of Patent: August 16, 2022Assignee: XIAMEN ECO LIGHTING CO. LTD.Inventors: Haifang Huang, Xiaowei Chen, Wenchang Huang, Wenbin Lin
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Patent number: 11389422Abstract: Nanoparticles comprising micheliolide (MCL) or derivatives thereof, and optionally additional therapeutic agents, such as chemotherapeutic agents, are described. Also described are methods of treating diseases, such as cancer, comprising the use of combinations of MCL or a derivative thereof with X-ray irradiation and/or other therapeutic agents, such as immune checkpoint inhibitors. The use of the combinations can provide synergistic anticancer therapeutic efficacy, for example, as the MCL or derivative thereof can both sensitize cancer cells to therapy and target resistant cancer stem cells (CSCs) for selective cell death.Type: GrantFiled: April 27, 2020Date of Patent: July 19, 2022Assignee: The University of ChicagoInventors: Wenbin Lin, Christina Chan, Wenbo Han
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Patent number: 11246877Abstract: Prodrugs containing lipid moieties attached to drug derivatives, such as anti-cancer drug derivatives, via linkers comprising disulfide groups are described. Also described are nanoparticles coated with a lipid layer containing the prodrugs, formulations comprising the nanoparticles, and the use of the nanoparticles in methods of treating diseases, such as cancer, alone or in combination with additional drug compounds, targeting agents, and/or immunotherapy agents, such as immunosuppression inhibitors that target the CTLA-4, PD-1/PD-L1, IDO, LAG-3, CCR-7 or other pathways, or multiple immunosuppression inhibitors targeting a combination of such pathways. Optionally, the nanoparticles can comprise a photosensitizer or a derivative thereof and can be used in methods involving photodynamic therapy. Synergistic therapeutic effects result from combinations of multiple modalities provided by the disclosed nanoparticles and/or nanoparticle formulations.Type: GrantFiled: May 22, 2017Date of Patent: February 15, 2022Assignee: The University of ChicagoInventors: Wenbin Lin, Xiaopin Duan, Christina Chan, Wenbo Han
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Publication number: 20210278635Abstract: The present invention provides an optical imaging lens. The optical imaging lens comprises seven lens elements positioned in an order from an object side to an image side. Through controlling the convex or concave shape of the surfaces of the lens elements, the optical imaging lens may shorten system length and enlarge field of view and aperture size.Type: ApplicationFiled: June 4, 2020Publication date: September 9, 2021Inventors: Huabin Liao, Wenbin Lin, Jiali Lian, Ou Zhou
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Publication number: 20210191084Abstract: The present invention provides an optical imaging lens. The optical imaging lens comprises eight lens elements positioned in an order from an object side to an image side. Through controlling convex or concave shape of surfaces of the lens elements, the optical imaging lens may shorten system length with a good imaging quality.Type: ApplicationFiled: March 17, 2020Publication date: June 24, 2021Inventors: CHUANBO DONG, WENBIN LIN, QINGZHI ZHU
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Publication number: 20210149166Abstract: An optical imaging lens includes a first lens element to a seventh lens element, and each lens element has an object-side surface and an image-side surface. The second lens element has negative refracting power, a periphery region of the object-side surface of the third lens element is concave, an optical axis region of the image-side surface of the third lens element is convex, the fifth lens element has positive refracting power, an optical axis region of the image-side surface of the fifth lens element is convex, an optical axis region of the image-side surface of the sixth lens element is concave, an optical axis region of the image-side surface of the seventh lens element is concave, a periphery region of the image-side surface of the seventh lens element is convex. The optical imaging lens satisfies the following conditions: D11t42/AAG37?1.700 and D11t31/G34?12.000.Type: ApplicationFiled: February 26, 2020Publication date: May 20, 2021Inventors: Jiayuan Zhang, Hai Lin, Wenbin Lin
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Patent number: 10989899Abstract: An optical imaging lens may include a first, a second, a third, and a fourth lens elements positioned in an order from an object side to an image side along an optical axis. Through designing concave and/or convex surfaces of the four lens elements, the optical imaging lens may provide improved imaging quality and optical characteristics, and have the ability to cooperate the demand of present smaller-sized electronic product while the optical imaging lens may satisfy TTL/TL?1.700 and EFL/ImgH?2.500, wherein a distance from the object-side surface of the first lens element to an image plane along the optical axis is represented by TTL, a distance from the object-side surface of the first lens element to the image-side surface of the fourth lens element along the optical axis is represented by TL, an effective focal length of the optical imaging lens is represented by EFL, and an image height of the optical imaging lens is represented by ImgH.Type: GrantFiled: July 24, 2018Date of Patent: April 27, 2021Assignee: Genius Electronic Optical (Xiamen) Co., Ltd.Inventors: Huabin Liao, Wenbin Lin, Hai Lin