Abstract: The invention provides protective sleeves for protectively covering an appendage and medicinal sites such as intravenous equipment, bandages, wounds, etc. The sleeve is open at both ends with adjustable elastic sections which effectively seal the sleeve against the appendage. The elastic sections are equipped with elastic drawstrings which circumscribe a cushioning resilient layer. When the drawstrings are drawn and tied together the elastic force of the drawstring applies a sealing force to the resilient layer causing the layer to conform to the appendage configuration and seal the elastic section against the appendage. The wearer of the protective sleeve may safely shower and protect the medicinal site from contamination. When finished showering, the drawstrings may be untied to release the contractive force so as to permit the sleeve to be removed from the appendage.