Abstract: Disclosed herein are method for separating, amplifying, or detecting a nucleic acid from a sample may comprise contacting a sample lysate with a plurality of buoyant, inorganic, nucleic-acid-capture microspheres. The nucleic-acid-capture microspheres may comprise unicellular hollow microspheres having a diameter between 5 and 300 ?m and/or a true particle density between 0.05 and 0.60 grams/cm3. The microspheres may comprise hollow soda-lime-borosilicate microspheres. In some embodiments, the microspheres comprises hollow soda-lime-borosilicate microspheres surrounded by an amorphous silica shell. Also disclosed are kits for performing the methods.

Abstract: Disclosed herein are method for separating, amplifying, or detecting a nucleic acid from a sample may comprise contacting a sample lysate with a plurality of buoyant, inorganic, nucleic-acid-capture microspheres. The nucleic-acid-capture microspheres may comprise unicellular hollow microspheres having a diameter between 5 and 300 ?m and/or a true particle density between 0.05 and 0.60 grams/cm3. The microspheres may comprise hollow soda-lime-borosilicate microspheres. In some embodiments, the microspheres comprises hollow soda-lime-borosilicate microspheres surrounded by an amorphous silica shell. Also disclosed are kits for performing the methods.

Abstract: The present invention relates to the rapid and electricity-free, point-of-care, multiplexed detection and quantification of at least one or more nucleic acid sequences from nucleic acids corresponding to a plurality of pathogens or biomarkers using a micropatterned lateral flow device. Rapid and molecular-level sensitive differential diagnosis of a disease condition may be enabled without the need for a delayed laboratory test so that timely treatment can be administered.

Abstract: The present invention relates to the rapid and electricity-free, point-of-care, multiplexed detection and quantification of at least one or more nucleic acid sequences from nucleic acids corresponding to a plurality of pathogens or biomarkers using a micropatterned lateral flow device. Rapid and molecular-level sensitive differential diagnosis of a disease condition may be enabled without the need for a delayed laboratory test so that timely treatment can be administered.

Abstract: Methods are disclosed herein for identifying a subject with irritable bowel syndrome (IBS). Methods are also disclosed for determining if an agent is effective for the treatment or prevention of IBS. Methods of treating a subject with IBS, such as a subject identified using the disclosed methods, are also provided.

Abstract: Methods are disclosed herein for identifying a subject with irritable bowel syndrome (IBS). Methods are also disclosed for determining if an agent is effective for the treatment or prevention of IBS. Methods of treating a subject with IBS, such as a subject identified using the disclosed methods, are also provided.

Abstract: The disclosure herein provides system, methods, and devices for generating debit cards. A debit card system for creating a plurality of debit cards comprises a debit card printer, a batch creation engine, a payment batches database, a deposit management engine, and a distribution engine, wherein the debit card printer comprises an imprinting mechanism, a magnetic strip writer, and a computer network interface. In an embodiment, the distribution engine is further configured to initiate creation of an alternate account on behalf of a recipient related to a debit card that is not activated within a predetermined amount of time, and to transmit to a deposit processing system instructions to enable a deposit into the alternate account of funds equal to a recipient payment amount.

Abstract: A cast for use in limiting movement of the hand to promote healing of an injured body part includes a water hardenable orthopaedic blank for mounting on the forearm, preferably with a thumb hole, and an outrigger, also impregnated with water hardenable material, secured to the blank for holding the thumb or fingers against movement. This construction minimizes irritation of the web between the thumb and forefinger and reduces discomfort and trauma caused by chafing and pressure.

Abstract: A cast or support assembly includes inner double knit padding material in which the outer layer is woven or knit to have substantial size openings, while the inner layer of the double knit material to be located against the skin of the patient is more closely woven or knit. Additional casting fabric is also provided, with this casting fabric being impregnated with water hardenable material. The outer casting fabric may include openings extending through it, so that the entire cast assembly has ventilation openings allowing air circulation to accomplish rapid drying following wetting of the assembly by sweat, rain, or by swimming, for example.

Abstract: A cast for use in limiting movement of the hand to promote healing of an injured body part includes a water hardenable orthopaedic blank for mounting on the forearm, preferably with a thumb hole, and an outrigger, also impregnated with water hardenable material, secured to the blank for holding the thumb or fingers against movement. This construction minimizes irritation of the web between the thumb and forefinger and reduces discomfort and trauma caused by chafing and pressure.

Abstract: A dispenser box for medical bandages including orthopedic splints is described. The dispenser box includes at least one moisture impermeable container connected with a face plate containing a periphery gasket. The bandage exits through a slot in the face plate. A door is pivotally connected to and mechanically biased against the face plate. When the door is closed, a moisture resistant environment is maintained for the stored bandage materials.

Abstract: A dispenser box for medical bandages including orthopedic splints is described. The dispenser box includes at least one moisture impermeable container connected with a face plate containing a periphery gasket. The bandage exits through a slot in the face plate. A door is pivotally connected to and mechanically biased against the face plate. When the door is closed, a moisture resistant environment is maintained for the stored bandage materials.

Abstract: A cast or support assembly includes inner double knit padding material in which the outer layer is woven or knit to have substantial size openings, while the inner layer of the double knit material to be located against the skin of the patient is more closely woven or knit. Additional casting fabric is also provided, with this casting fabric being impregnated with water hardenable material. The outer casting fabric may include openings extending through it, so that the entire cast assembly has ventilation openings allowing air circulation to accomplish rapid drying following wetting of the assembly by sweat, rain, or by swimming, for example.

Abstract: The present invention provides improved hardenable orthopaedic supports and methods of making the same. One embodiment provides a support which includes a blank made of a permeable, flexible material and including a structural region impregnated with a hardenable material and a peripheral region which will remain flexible after the hardenable material is hardened. Another embodiment provides a method of manufacturing an orthopaedic support in which a permeable, flexible material is positioned adjacent a recess of a molding element; the flexible material is contacted with a hardenable material; and the hardenable material is placed under pressure in the molding element to impregnate the section of the flexible material with the hardenable material.

Abstract: An orthopaedic splint apparatus and technique involving the use of a water hardenable blank with (1) primary tacking arrangements for adjustably holding the splint or support in place after it has been activated and placed on the injured part of the anatomy, and may also include (2) secondary, functional arrangements for holding the splint firmly in place following accurate mounting and location of the splint on the injured part of the anatomy. The tacking arrangements may involve the use of lateral extensions from the main body of the splint with hook and loop type fasteners or adhesive associated with the extensions for holding the splint onto the injured part of the anatomy.

Abstract: An orthopaedic splint technique involves the use of a water hardenable blank, with (1) primary tacking arrangements for adjustably holding the splint or support in place after it has been activated and placed on the injured part of the anatomy, and may also include (2) functional arrangements for holding the splint firmly in place following accurate mounting and location of the splint on the injured part of the anatomy. The tacking arrangements may involve the use of lateral extensions from the main body of the splint with hook and loop type arrangements or adhesive associated with the extensions for holding the splint onto the injured part of the anatomy.

Abstract: An orthopedic support assembly has a shape which is well-suited to be reliably positioned on a patient's anatomical structure, e.g., a limb or other extremity. Designs in accordance with certain embodiments include two or more lobes joined by one or more narrower joining region.

Abstract: An orthopaedic support assembly is formed of a flexible material impregnated with a hardenable material, e.g. a water-hardenable urethane. The orthopaedic support may include an outer layer of napped material, e.g., an unbroken loop material, that reduces migration of the hardenable material. The orthopaedic support may also include an inner layer of foam padding to increase the comfort of the patient.

Abstract: An orthopaedic support assembly is formed of a flexible material impregnated with a hardenable material, e.g. a water-hardenable urethane. The orthopaedic support may include an outer layer of napped material, e.g., an unbroken loop material, that reduces migration of the hardenable material. The orthopaedic support may also include an inner layer of foam padding to increase the comfort of the patient.

Abstract: An orthopedic support assembly has a shape which is well-suited to be reliably positioned on a patient's anatomical structure, e.g., a limb or other extremity. Designs in accordance with certain embodiments include two or more lobes joined by one or more narrower joining region.